Inhibition of Mitochondrial Translation Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation by Targeting Vγ4+ γδ T Cells.

Antibiotics Imiquimod Linezolid Mitochondria Psoriasis

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
12 Oct 2023
Historique:
received: 13 01 2023
revised: 20 09 2023
accepted: 21 09 2023
pubmed: 14 10 2023
medline: 14 10 2023
entrez: 13 10 2023
Statut: aheadofprint

Résumé

Psoriasis is an inflammatory skin disorder that is characterized by keratinocyte hyperproliferation in response to immune cell infiltration and cytokine secretion in the dermis. γδ T cells expressing the Vγ4 TCR chain are among the highest contributors of IL-17A, which is a major cytokine that drives a psoriasis flare, making Vγ4

Identifiants

DOI: 10.1016/j.jid.2023.09.275 PMID: 37832844
pubmed: 37832844
pii: S0022-202X(23)02924-X
doi: 10.1016/j.jid.2023.09.275
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Ayesha Dhillon-LaBrooy (A)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Kathrin L Braband (KL)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Eshraq Tantawy (E)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Francesca Rampoldi (F)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Yu-San Kao (YS)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Fatima Boukhallouk (F)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Lis Noelia Velasquez (LN)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Panagiota Mamareli (P)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Luana Silva (L)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Luis Eduardo Alves Damasceno (LEA)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, São Paulo, Brazil.

Beate Weidenthaler-Barth (B)

Department of Dermatology, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Luciana Berod (L)

Institute of Molecular Medicine, University Medical Center of the Johannes University Gutenberg, Mainz, Germany; Research Center for Immunotherapy, University Medical Centre of the Johannes University Gutenberg, Mainz, Germany.

Luís Almeida (L)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany.

Tim Sparwasser (T)

Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes University Gutenberg, Mainz, Germany; Research Center for Immunotherapy, University Medical Centre of the Johannes University Gutenberg, Mainz, Germany. Electronic address: sparwasser@uni-mainz.de.

Classifications MeSH