Short-term disengagement from early intervention service for first-episode psychosis: findings from the "Parma Early Psychosis" program.

Disengagement Drop-out Early intervention in psychosis First-episode psychosis Follow-up Outcome

Journal

Social psychiatry and psychiatric epidemiology
ISSN: 1433-9285
Titre abrégé: Soc Psychiatry Psychiatr Epidemiol
Pays: Germany
ID NLM: 8804358

Informations de publication

Date de publication:
13 Oct 2023
Historique:
received: 24 05 2023
accepted: 28 09 2023
medline: 13 10 2023
pubmed: 13 10 2023
entrez: 13 10 2023
Statut: aheadofprint

Résumé

Service disengagement is a major concern for "Early Intervention in Psychosis" (EIP). Indeed, identifying predictors of engagement is crucial to maximize mental healthcare interventions in first-episode psychosis (FEP). No Italian study on this topic has been reported to date. Thus, the aims of this investigation were: (1) to examine short-term disengagement rate in an Italian population of FEP patients treated within an EIP service across a 1-year follow-up period, and (b) to assess the most relevant predictors of disengagement in the first year of treatment. All participants were young FEP help-seeking patients, aged 12-35 years, enrolled within the "Parma Early Psychosis" (Pr-EP) protocol. At baseline, they completed the Positive And Negative Syndrome Scale (PANSS), the Health of the Nation Outcome Scale (HoNOS) and the Global Assessment of Functioning (GAF) scale. Univariate and multivariate Cox regression analyses were used. 496 FEP individuals were enrolled in this research. Across the follow-up, a 16.5% prevalence of short-term disengagement was found. Particularly robust predictors of service disengagement were poor baseline treatment non-adherence, living with parents and the presence of brief psychotic disorder or schizophreniform disorder at entry. About 16% of FEP patients disengaged the Pr-EP program within the first year of treatment. A solution to reduce disengagement and/or to favor re-engagement of these subjects might be to remain on EIP program caseloads allowing the option for low-intensity support and monitoring, also via remote technology.

Identifiants

pubmed: 37831081
doi: 10.1007/s00127-023-02564-3
pii: 10.1007/s00127-023-02564-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s).

Références

Lal S, Malla A (2015) Service engagement in first episode psychosis: current issues and future directions. Can J Psychiatry 60:341–345. https://doi.org/10.1177/070674371506000802
doi: 10.1177/070674371506000802 pubmed: 26454555 pmcid: 4542513
Mitchell A, Selmes T (2007) Why don’t patients attend their appointments? Maintaining engagement with psychiatric services. Adv Psychiatr Treat 13:423–434. https://doi.org/10.1192/apt.bp.106.003202
doi: 10.1192/apt.bp.106.003202
Reynolds S, Brown E, Kim DJ, Geros H, Sizer H, Eaton S, Tindall R, McGorry P, O’Donoghue B (2019) The association between community and service level factors and rates of disengagement in individuals with first episode psychosis. Schizophr Res 210:122–127. https://doi.org/10.1016/j.schres.2019.05.037
doi: 10.1016/j.schres.2019.05.037 pubmed: 31176534
Correll CU, Galling B, Pawar A, Krivko A, Bonetto C, Ruggeri M, Craig TJ, Nordentoft M, Srihari VH, Guloksuz S, Hui CLM, Chen EYH, Valencia M, Juarez F, Robinson DG, Schooler NR, Brunette MF, Mueser KT, Rosenheck RA, Marcy P, Addington J, Estroff SE, Robinson J, Penn D, Severe JB, Kane JM (2018) Comparison of early intervention services vs treatment as usual for early-phase psychosis: a systematic review, meta-analysis, and meta-regression. JAMA Psychiat 75:555–565. https://doi.org/10.1001/jamapsychiatry.2018.0623
doi: 10.1001/jamapsychiatry.2018.0623
Poletti M, Preti A, Raballo A (2022) Mind the (transition) gap: youth mental health-oriented early intervention services to overcome the child-adolescent vs. adult hiatus. Front Psychiatry 13:965467. https://doi.org/10.3389/fpsyt.2022.965467
Robson E, Greenwood K (2022) Rates and predictors of disengagement and strength of engagement for people with a first episode of psychosis using early intervention services: a systematic review of predictors and meta-analysis of disengagement rates. Schizophr Bull Open. https://doi.org/10.1093/schizbullopen/sgac012
Doyle R, Turner N, Fanning F, Brennan D, Renwick L, Lawlor E, Clarke M (2014) First-episode psychosis and disengagement from treatment: a systematic review. Psychiatr Serv 65:603–611. https://doi.org/10.1176/appi.ps.201200570
doi: 10.1176/appi.ps.201200570 pubmed: 24535333
Mascayano F, van der Ven E, Martinez-Ales G, Henao AR, Zambrano J, Jones N, Cabassa LJ, Smith TE, Yang LH, Susser E, Dixon LB (2021) Disengagement from early intervention services for psychosis: a systematic review. Psychiatr Serv 72:49–60. https://doi.org/10.1176/appi.ps.201900375
doi: 10.1176/appi.ps.201900375 pubmed: 33234052
Raballo A, Poletti M, McGorry P (2017) Architecture of change: rethinking child and adolescent mental health. Lancet Psychiatry 4:656–658. https://doi.org/10.1016/S2215-0366(17)30315-2
doi: 10.1016/S2215-0366(17)30315-2 pubmed: 28853403
Pelizza L, Leuci E, Quattrone E, Paulillo G, Pellegrini P (2023). The “Parma At-Risk Mental States” (PARMS) program: general description and process analysis after 5 years of clinical activity. Early Interv Psychiatry. https://doi.org/10.1111/eip.13399
Scazza I, Pelizza L, Azzali S, Garlassi S, Paterlini F, Chiri LR, Poletti M, Pupo S, Raballo A (2022) Aberrant salience in first-episode psychosis: longitudinal stability and treatment-response. Early Interv Psychiatry 16:912–919. https://doi.org/10.1111/eip.13243
doi: 10.1111/eip.13243 pubmed: 34786863
Addington D, McKenzie E, Addington J, Patten S, Smith H, Adair C (2005) Performance measures for early psychosis treatment services. Psychiatr Serv 56:1570–1582. https://doi.org/10.1176/appi.ps.56.12.1570
doi: 10.1176/appi.ps.56.12.1570 pubmed: 16339620
Qi W, Marx J, Zingman M, Li Y, Petkova E, Blessing E, Ardekani B, Sakalli Kani A, Cather C, Freudenreich O, Holt D, Zhao J, Wang J, Goff DC (2023) Hippocampal subfield volumes predict disengagement from maintenance treatment in first episode schizophrenia. Schizophr Bull 49:34–42. https://doi.org/10.1093/schbul/sbac043
doi: 10.1093/schbul/sbac043 pubmed: 36370124
Conus P, Lambert M, Cotton S, Bonsack C, McGorry PD, Schimmelmann BG (2010) Rate and predictors of service disengagement in an epidemiological first-episode psychosis cohort. Schizophr Res 118:256–263. https://doi.org/10.1016/j.schres.2010.01.032
Turner M, Smith-Hamel C, Mulder R (2007) Prediction of twelve-month service disengagement from an early intervention in psychosis service. Early Interv Psychiatry 1:276–281. https://doi.org/10.1111/j.1751-7893.2007.00039.x
doi: 10.1111/j.1751-7893.2007.00039.x
Dixon LB, Holoshitz Y, Nossel I (2016) Treatment engagement of individuals experiencing mental illness: review and update. World Psychiatry 15:13–20. https://doi.org/10.1002/wps.20306
doi: 10.1002/wps.20306 pubmed: 26833597 pmcid: 4780300
O’Brien A, Fahmy R, Singh SP (2009) Disengagement from mental health services: a literature review. Soc Psychiatry Psychiatr Epidemiol 44:558–568. https://doi.org/10.1007/s00127-008-0476-0
doi: 10.1007/s00127-008-0476-0 pubmed: 19037573
McGorry PD (2015) Early intervention in psychosis: obvious, effective, overdue. J Nerv Ment Dis 203:310–318. https://doi.org/10.1097/NMD.0000000000000284
doi: 10.1097/NMD.0000000000000284 pubmed: 25919380 pmcid: 4414340
Myers N, Bhatty S, Broussard B, Compton MT (2017) Clinical correlates of initial treatment disengagement in first-episode psychosis. Clin Schizophr Relat Psychoses 11:95–102. https://doi.org/10.3371/CSRP.MYBH.103114
doi: 10.3371/CSRP.MYBH.103114 pubmed: 25367162
Kominski G (2014) Changing the US health care system: key issues in health service policy and management. Wiley, San Francisco
Golay P, Ramain J, Reiff C, Solida A, Baumann PS, Conus P (2020) Rate and predictors of disengagement in an early psychosis program with time limited intensification of treatment. J Psychiatr Res 131:33–38. https://doi.org/10.1016/j.jpsychires.2020.08.036
doi: 10.1016/j.jpsychires.2020.08.036 pubmed: 32916376
Zheng S, Poon LY, Verma S (2013) Rate and predictors of service disengagement among patients with first-episode psychosis. Psychiatr Serv 64:812–815. https://doi.org/10.1176/appi.ps.201200199
doi: 10.1176/appi.ps.201200199 pubmed: 23903608
Chan TC, Chang WC, Hui CL, Chan SK, Lee EH, Chen EY (2014) Rate and predictors of disengagement from a 2-year early intervention program for psychosis in Hong Kong. Schizophr Res 153:204–208. https://doi.org/10.1016/j.schres.2014.01.033
doi: 10.1016/j.schres.2014.01.033 pubmed: 24530136
Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P, Raballo A (2021) Disorganization in first episode schizophrenia: treatment response and psychopathological findings from the 2-year follow-up of the “Parma-Early Psychosis” program. J Psychiatr Res 141:293–300. https://doi.org/10.1016/j.jpsychires.2021.07.015
doi: 10.1016/j.jpsychires.2021.07.015 pubmed: 34274840
American Psychiatric Association (2013) Diagnostic and Statistical Manual of mental disorder, 5th edn. APA Publishing, Arlington
doi: 10.1176/appi.books.9780890425596
Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Examining disorganization in patients with first episode psychosis: findings from a 1-year follow-up of the “Parma-Early psychosis” program. Early Interv Psychiatry 16:552–560. https://doi.org/10.1111/eip.13198
doi: 10.1111/eip.13198 pubmed: 34279049
Woods SW, Yung AR, McGorry PD, McGlashan TH (2020) Duration of untreated psychosis: getting both the timing and the sample right. Am J Psychiatry 177:1183. https://doi.org/10.1176/appi.ajp.2020.20040389
doi: 10.1176/appi.ajp.2020.20040389 pubmed: 33256446
Raballo A, Poletti M (2020) Advances in early identification of children and adolescents at risk for psychiatric illness. Curr Opin Psychiatry 33:611–617. https://doi.org/10.1097/YCO.0000000000000652
doi: 10.1097/YCO.0000000000000652 pubmed: 32858604
Leuci E, Pelizza L, Landi G, Quattrone E, Maestri D, Azzali S, Pelosi A, Ceroni P, Soncini C, Daolio MC, Paulillo G, Raballo A, Pellegrini P (2022) Personal health budget in patients with first episode psychosis: a new rehabilitation model based on a community care system in Italy. Early Interv Psychiatry 16:221–230. https://doi.org/10.1111/eip.13145
doi: 10.1111/eip.13145 pubmed: 33754490
Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell’Olio M, Francey SM, Cosgrave EM, Killackey E, Stanford C, Godfrey K, Buckby J (2005) Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states. Aust N Z J Psychiatry 39:964–971. https://doi.org/10.1080/j.1440-1614.2005.01714.x
doi: 10.1080/j.1440-1614.2005.01714.x pubmed: 16343296
Early Psychosis Guidelines Writing Group and EPPIC National Support Program (2016) Australian Clinical Guidelines for Early Psychosis, 2nd edition update. Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne
National Institute for health and Care Excellence (NICE) (2016) Psychosis and schizophrenia in children and young people: recognition and management. NICE Publishing, London
Lian L, Kim DD, Procyshyn RM, Fredrikson DH, Cázares D, Honer WG, Barr AM (2022) Efficacy of long-acting injectable versus oral antipsychotic drugs in early psychosis: a systematic review and meta-analysis. Early Interv Psychiatry 16:589–599. https://doi.org/10.1111/eip.13202
doi: 10.1111/eip.13202 pubmed: 34263540
Crouse JJ, Carpenter JS, Song YJC, Hockey SJ, Naismith SL, Grunstein RR, Scott EM, Merikangas KR, Scott J, Hickie IB (2021) Circadian rhythm sleep-wake disturbances and depression in young people: implications for prevention and early intervention. Lancet Psychiatry 8:813–823. https://doi.org/10.1016/S2215-0366(21)00034-1
doi: 10.1016/S2215-0366(21)00034-1 pubmed: 34419186
Garety PA, Kuipers E, Fowler D, Freeman D, Bebbington PE (2001) A cognitive model of the positive symptoms of psychosis. Psychol Med 31:189–195. https://doi.org/10.1017/s0033291701003312
doi: 10.1017/s0033291701003312 pubmed: 11232907
McFarlane WR (2016) Family interventions for schizophrenia and the psychoses: a review. Fam Process 55:460–482. https://doi.org/10.1111/famp.12235
doi: 10.1111/famp.12235 pubmed: 27411376
Pelizza L, Ficarelli ML, Vignali E, Artoni S, Franzini MC, Montanaro S, Andreoli MV, Marangoni S, Ciampà E, Erlicher D, Troisi E, Pupo S (2020) Individual placement and support in Italian young adults with mental disorder: findings from the Reggio Emilia experience. Early Interv Psychiatry 14:577–586. https://doi.org/10.1111/eip.12883
doi: 10.1111/eip.12883 pubmed: 31642590
Landi G, Leuci E, Quattrone E, Azzali S, Pellegrini C, Pellegrini P, Pellegrini P, Pelizza L (2021) The “Parma-Early Psychosis” programme: characterization of help-seekers with first episode psychosis. Early Interv Psychiatry 15:380–390. https://doi.org/10.1111/eip.12968
doi: 10.1111/eip.12968 pubmed: 32307896
Pelizza L, Maestri D, Leuci E, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Individual psychotherapy can reduce suicidal ideation in first episode psychosis: further findings from the 2-year follow-up of the “Parma Early Psychosis” programme. Clin Psychol Psychother 29:982–989. https://doi.org/10.1002/cpp.2678
doi: 10.1002/cpp.2678 pubmed: 34704336
First MB, Williams JBW, Karg RS, Spitzer RL (2016) Structured Clinical Interview for DSM-5 disorders, Clinical Version (SCID-5-CV). APA Publishing, Washington
Pelizza L, Paterlini F, Azzali S, Garlassi S, Scazza I, Pupo S, Simmons M, Nelson B, Raballo A (2019) The approved Italian version of the comprehensive assessment of at-risk mental states (CAARMS-ITA): field test and psychometric features. Early Interv Psychiatry 13:810–817. https://doi.org/10.1111/eip.12669
doi: 10.1111/eip.12669 pubmed: 29696795
Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276. https://doi.org/10.1093/schbul/13.2.261
doi: 10.1093/schbul/13.2.261 pubmed: 3616518
Wing JK, Beevor AS, Curtis RH, Park SB, Hadden S, Burns A (1998) Health of the Nation Outcome Scales (HoNOS): research and development. Br J Psychiatry 172:11–18. https://doi.org/10.1192/bjp.172.1.11
doi: 10.1192/bjp.172.1.11 pubmed: 9534825
Pelizza L, Leuci E, Landi G, Maestri D, Paulillo G, Ceroni P, Soncini C, Daolio MC, Quattrone E, Pellegrini P (2021) Personal Health Budget as a new rehabilitation model for severe mental illness within a caring community: an Italian evaluation study of beneficial effects. Aust N Z J Psychiatry 55:602–612. https://doi.org/10.1177/0004867420968918
doi: 10.1177/0004867420968918 pubmed: 33111536
Pelizza L, Maestri D, Leuci E, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2020) Negative symptom configuration within and outside schizophrenia spectrum disorders: results from the “Parma-Early Psychosis” program. Psychiatry Res 294:113519. https://doi.org/10.1016/j.psychres.2020.113519
doi: 10.1016/j.psychres.2020.113519 pubmed: 33130513
Shafer A, Dazzi F (2019) Meta-analysis of the positive and Negative Syndrome Scale (PANSS) factor structure. J Psychiatr Res 115:113–120. https://doi.org/10.1016/j.jpsychires.2019.05.008
doi: 10.1016/j.jpsychires.2019.05.008 pubmed: 31128501
Pancheri P, Brugnoli R, Carilli L, Delle Chiaie R, Marconi PL, Petrucci RM (1995) Valutazione dimensionale della sintomatologia schizofrenica: validazione della versione italiana della Scala per la valutazione dei Sintomi Positivi e Negativi (PANSS) G Ital Psicopatol 1:60–75
Pelizza L, Pellegrini C, Quattrone E, Azzali S, Landi G, Pellegrini P, Leuci E (2022) Suicidal thinking and behavior in first episode schizophrenia: findings from the 24-month follow-up of the “Parma-Early Psychosis” program. Arch Suicide Res 26:656–676. https://doi.org/10.1080/13811118.2020.1820411
doi: 10.1080/13811118.2020.1820411 pubmed: 32970972
Pelizza L, Maestri D, Leuci E, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Association between case management and longitudinal decrease in negative symptoms in patients with first episode psychosis: a 2-year follow-up. Early Interv Psychiatry 16:1185–1191. https://doi.org/10.1111/eip.13267
doi: 10.1111/eip.13267 pubmed: 35086160
Golay P, Basterrechea L, Conus P, Bonsack C (2016) Internal and predictive validity of the French Health of the Nation Outcome Scales: need for future directions. PLoS ONE 11:e0160360. https://doi.org/10.1371/journal.pone.0160360
doi: 10.1371/journal.pone.0160360 pubmed: 27483015 pmcid: 4970811
Parabiaghi A, Barbato A, D’Avanzo B, Erlicher A, Lora A (2005) Assessing reliable and clinically significant change on Health of the Nation Outcome Scales: method for displaying longitudinal data. Aust N Z J Psychiatry 39:719–725. https://doi.org/10.1080/j.1440-1614.2005.01656.x
doi: 10.1080/j.1440-1614.2005.01656.x pubmed: 16050926
Preti A, Pisano A, Cascio MT, Galvan F, Monzani E, Meneghelli A, Cocchi A (2012) Validation of the Health of the Nation Outcome Scales as a routine measure of outcome in early intervention programmes. Early Interv Psychiatry 6:423–431. https://doi.org/10.1111/j.1751-7893.2011.00329.x
doi: 10.1111/j.1751-7893.2011.00329.x pubmed: 22225572
Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Longitudinal persistence of negative symptoms in young individuals with first episode schizophrenia: a 24-month multi-modal program follow-up. Nord J Psychiatry 76:530–538. https://doi.org/10.1080/08039488.2021.2015431
doi: 10.1080/08039488.2021.2015431 pubmed: 34936855
Tompsett T, Masters K, Donyai P (2018) The utility of novel outcome measures in a naturalistic evaluation of schizophrenia treatment. Neuropsychiatr Dis Treat 14:681–691. https://doi.org/10.2147/NDT.S151174
doi: 10.2147/NDT.S151174 pubmed: 29535524 pmcid: 5841343
Trevithick L, Painter J, Keown P (2015) Mental health clustering and diagnosis in psychiatric in-patients. BJPsych Bull 39:119–123. https://doi.org/10.1192/pb.bp.114.047043
doi: 10.1192/pb.bp.114.047043 pubmed: 26191449 pmcid: 4478925
Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Negative symptoms in first episode schizophrenia: treatment response across the 2-year follow-up of the “Parma-Early Psychosis” program. Eur Arch Psychiatry Clin Neurosci 272:621–632. https://doi.org/10.1007/s00406-021-01374-5
doi: 10.1007/s00406-021-01374-5 pubmed: 35088121
Stowkowy J, Addington D, Liu L, Hollowell B, Addington J (2012) Predictors of disengagement from treatment in an early psychosis program. Schizophr Res 136:7–12. https://doi.org/10.1016/j.schres.2012.01.027
doi: 10.1016/j.schres.2012.01.027 pubmed: 22336955
Turner MA, Boden JM, Smith-Hamel C, Mulder RT (2009) Outcomes for 236 patients from a 2-year early intervention in psychosis service. Acta Psychiatr Scand 120:129–137. https://doi.org/10.1111/j.1600-0447.2009.01386.x
doi: 10.1111/j.1600-0447.2009.01386.x pubmed: 19392808
SPSS Inc (2010) Statistical package for social science (SPSS) for windows, version 15.0. SPSS Press, Chicago
Dey T, Lipsitz SR, Cooper Z, Trinh QD, Krzywinski M, Altman N (2022) Survival analysis: time-to-event data and censoring. Nat Methods 19:906–908. https://doi.org/10.1038/s41592-022-01563-7
doi: 10.1038/s41592-022-01563-7 pubmed: 35927476
Atem FD, Matsouaka RA, Zimmern VE (2019) Cox regression model with randomly censored covariates. Biom J 61:1020–1032. https://doi.org/10.1002/bimj.201800275
doi: 10.1002/bimj.201800275 pubmed: 30908720 pmcid: 6922001
Sedgwick P (2013) Cox proportional hazards regression. BMJ 47:f4919. https://doi.org/10.1136/bmj.f4919
doi: 10.1136/bmj.f4919
Hamilton JE, Srivastava D, Womack D, Brown A, Schulz B, Macakanja A, Walker A, Wu MJ, Williamson M, Cho RY (2019) Treatment retention among patients participating in coordinated specialty care for first-episode psychosis: a mixed-methods analysis. J Behav Health Serv Res 46:415–433. https://doi.org/10.1007/s11414-018-9619-6
doi: 10.1007/s11414-018-9619-6 pubmed: 29873034
Casey D, Brown L, Gajwani R, Islam Z, Jasani R, Parsons H, Tah P, Birchwood M, Singh SP (2016) Predictors of engagement in first-episode psychosis. Schizophr Res 175:204–208. https://doi.org/10.1016/j.schres.2016.04.030
doi: 10.1016/j.schres.2016.04.030 pubmed: 27132495
Garety PA, Rigg A (2001) Early psychosis in the inner city: a survey to inform service planning. Soc Psychiatry Psychiatr Epidemiol 36:537–344. https://doi.org/10.1007/s001270170004
doi: 10.1007/s001270170004 pubmed: 11824848
Iyer SN, Malla A, Taksal A, Maraj A, Mohan G, Ramachandran P, Margolese HC, Schmitz N, Joober R, Rangaswamy T (2022) Context and contact: a comparison of patient and family engagement with early intervention services for psychosis in India and Canada. Psychol Med 52:1538–1547. https://doi.org/10.1017/S0033291720003359
doi: 10.1017/S0033291720003359 pubmed: 32981550
Lecomte T, Spidel A, Leclerc C, MacEwan GW, Greaves C, Bentall RP (2008) Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis. Schizophr Res 102:295–302. https://doi.org/10.1016/j.schres.2008.01.024
doi: 10.1016/j.schres.2008.01.024 pubmed: 18295458
MacBeth A, Gumley A, Schwannauer M, Carcione A, McLeod HJ, Dimaggio G (2016) Metacognition in first episode psychosis: item level analysis of associations with symptoms and engagement. Clin Psychol Psychother 23:329–339. https://doi.org/10.1002/cpp.1959
doi: 10.1002/cpp.1959 pubmed: 25963712
Tait L, Birchwood M, Trower P (2002) A new scale (SES) to measure engagement with community mental health services. J Ment Health 11:191–198. https://doi.org/10.1080/09638230020023570-2
doi: 10.1080/09638230020023570-2 pubmed: 21208145
O’Brien A, White S, Fahmy R, Singh SP (2009) The development and validation of the SOLES, a new scale measuring engagement with mental health services in people with psychosis. J Ment Health 18:510–522. https://doi.org/10.3109/09638230902968225
doi: 10.3109/09638230902968225
Albert N, Melau M, Jensen H, Emborg C, Jepsen JR, Fagerlund B, Gluud C, Mors O, Hjorthøj C, Nordentoft M (2017) Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis: randomised, superiority, parallel group trial in Denmark (OPUS II). BMJ 12(356):i6681. https://doi.org/10.1136/bmj.i6681
doi: 10.1136/bmj.i6681
Lau KW, Chan SKW, Hui CLM, Lee EHM, Chang WC, Chong CS, Lo WT, Chen EYH (2019) Rates and predictors of disengagement of patients with first-episode psychosis from the early intervention service for psychosis service (EASY) covering 15 to 64 years of age in Hong Kong. Early Interv Psychiatry 13:398–404. https://doi.org/10.1111/eip.12491
doi: 10.1111/eip.12491 pubmed: 28984042
Tranulis C, Goff D, Henderson DC, Freudenreich O (2011) Becoming adherent to antipsychotics: a qualitative study of treatment-experienced schizophrenia patients. Psychiatr Serv 62:888–892. https://doi.org/10.1176/ps.62.8.pss6208_0888
doi: 10.1176/ps.62.8.pss6208_0888 pubmed: 21807827
Tindall RM, Simmons MB, Allott K, Hamilton BE (2018) Essential ingredients of engagement when working alongside people after their first episode of psychosis: a qualitative meta-synthesis. Early Interv Psychiatry 12:784–795. https://doi.org/10.1111/eip.12566
doi: 10.1111/eip.12566 pubmed: 29624917
Polillo A, Voineskos AN, Foussias G, Kidd SA, Bromley S, Soklaridis S, Wang W, Stergiopoulos V, Kozloff N (2022) Disengagement from early psychosis intervention services: an observational study informed by a survey of patient and family perspectives. Schizophrenia (Heidelb) 8:94. https://doi.org/10.1038/s41537-022-00300-5
doi: 10.1038/s41537-022-00300-5 pubmed: 36369306
Alston M, Bennett CF, Rochani H (2019) Treatment adherence in youth with first-episode psychosis: impact of family support and telehealth delivery. Issues Ment Health Nurs 40:951–956. https://doi.org/10.1080/01612840.2019.1630532
doi: 10.1080/01612840.2019.1630532 pubmed: 31381462
D’Arcey J, Collaton J, Kozloff N, Voineskos AN, Kidd SA, Foussias G (2020) The use of text messaging to improve clinical engagement for individuals with psychosis: systematic review. JMIR Ment Health 7:e16993. https://doi.org/10.2196/16993
doi: 10.2196/16993 pubmed: 32238334 pmcid: 7163420
Thomas EC, Suarez J, Lucksted A, Siminoff L, Hurford I, Dixon L, O’Connell M, Salzer M (2022) Treatment decision-making needs among emerging adults with early psychosis. Early Interv Psychiatry 16:78–90. https://doi.org/10.1111/eip.13134
doi: 10.1111/eip.13134 pubmed: 33599089
Poletti M, Pelizza L, Azzali S, Paterlini F, Garlassi S, Scazza I, Chiri LR, Pupo S, Raballo A (2021) Overcoming the gap between child and adult mental health services: the Reggio Emilia experience in an early intervention in psychosis program. Early Interv Psychiatry 15:1749–1758. https://doi.org/10.1111/eip.13097
doi: 10.1111/eip.13097 pubmed: 33264817
Anderson KK, Fuhrer R, Schmitz N, Malla AK (2013) Determinants of negative pathways to care and their impact on service disengagement in first-episode psychosis. Soc Psychiatry Psychiatr Epidemiol 48:125–136. https://doi.org/10.1007/s00127-012-0571-0
doi: 10.1007/s00127-012-0571-0 pubmed: 22976337
Lucksted A, Essock SM, Stevenson J, Mendon SJ, Nossel IR, Goldman HH, Goldstein AB, Dixon LB (2015) Client views of engagement in the RAISE connection program for early psychosis recovery. Psychiatr Serv 66:699–704. https://doi.org/10.1176/appi.ps.201400475
doi: 10.1176/appi.ps.201400475 pubmed: 25873029 pmcid: 4490071
Poletti M, Gebhardt E, Pelizza L, Preti A, Raballo A (2020) Looking at intergenerational risk factors in schizophrenia spectrum disorders: new frontiers for early vulnerability identification? Front Psychiatry 11:566683. https://doi.org/10.3389/fpsyt.2020.566683
doi: 10.3389/fpsyt.2020.566683 pubmed: 33192689 pmcid: 7649773
von Peter S, Aderhold V, Cubellis L, Bergström T, Stastny P, Seikkula J, Puras D (2019) Open dialogue as a human rights-aligned approach. Front Psychiatry 31(10):387. https://doi.org/10.3389/fpsyt.2019.00387
doi: 10.3389/fpsyt.2019.00387
Lopez-Díaz Á, Ayesa-Arriola R, Ortíz-Garcia de la Foz V, Suarez-Pinilla P, Ramírez-Bonilla ML, Vazquez-Bourgon J, Ruiz-Veguilla M, Crespo-Facorro B (2021) Predictors of diagnostic stability in brief psychotic disorders: findings from a 3-year longitudinal study. Acta Psychiatr Scand 144:578–588. https://doi.org/10.1111/acps.13364
doi: 10.1111/acps.13364 pubmed: 34431080
Fusar-Poli P, Salazar de Pablo G, Rajkumar RP, López-Díaz Á, Malhotra S, Heckers S, Lawrie SM, Pillmann F (2022) Diagnosis, prognosis, and treatment of brief psychotic episodes: a review and research agenda. Lancet Psychiatry 9:72–83. https://doi.org/10.1016/S2215-0366(21)00121-8
doi: 10.1016/S2215-0366(21)00121-8 pubmed: 34856200
Fusar-Poli P, Cappucciati M, Rutigliano G, Heslin M, Stahl D, Brittenden Z, Caverzasi E, McGuire P, Carpenter WT (2016) Diagnostic stability of ICD/DSM first episode psychosis diagnoses: meta-analysis. Schizophr Bull 42:1395–1406. https://doi.org/10.1093/schbul/sbw020
doi: 10.1093/schbul/sbw020 pubmed: 26980142 pmcid: 5049518
Maguire J, Sizer H, Mifsud N, O’Donoghue B (2020) Outcomes for migrants with a first episode of psychosis: a systematic review. Schizophr Res 222:42–48. https://doi.org/10.1016/j.schres.2020.05.048
doi: 10.1016/j.schres.2020.05.048 pubmed: 32561236
Tarricone I, D’Andrea G, Jongsma HE, Tosato S, Gayer-Anderson C, Stilo SA, Suprani F, Iyegbe C, van der Ven E, Quattrone D, di Forti M, Velthorst E, Rossi Menezes P, Arango C, Parellada M, Lasalvia A, La Cascia C, Ferraro L, Bobes J, Bernardo M, Sanjuán I, Santos JL, Arrojo M, Del-Ben CM, Tripoli G, Llorca PM, de Haan L, Selten JP, Tortelli A, Szöke A, Muratori R, Rutten BP, van Os J, Jones PB, Kirkbride JB, Berardi D, Murray RM, Morgan C (2022) Migration history and risk of psychosis: results from the multinational EU-GEI study. Psychol Med 52:2972–2984. https://doi.org/10.1017/S003329172000495X
doi: 10.1017/S003329172000495X pubmed: 33563347

Auteurs

Lorenzo Pelizza (L)

Department of Biomedical and Neuromotor Sciences, "Alma Mater Studiorum", Università di Bologna, Viale Pepoli, 5, 40126, Bologna, BO, Italy. lorenzo.pelizza@unibo.it.
Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Parma, PR, Italy. lorenzo.pelizza@unibo.it.

Emanuela Leuci (E)

Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Parma, PR, Italy.

Emanuela Quattrone (E)

Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Parma, PR, Italy.

Silvia Azzali (S)

Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, RE, Italy.

Simona Pupo (S)

Pain Therapy Service, Department of Medicine and Surgery, Azienda Ospedaliero-Universitaria di Parma, Parma, PR, Italy.

Giuseppina Paulillo (G)

Pain Therapy Service, Department of Medicine and Surgery, Azienda Ospedaliero-Universitaria di Parma, Parma, PR, Italy.

Pietro Pellegrini (P)

Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Parma, PR, Italy.

Marco Menchetti (M)

Department of Biomedical and Neuromotor Sciences, "Alma Mater Studiorum", Università di Bologna, Viale Pepoli, 5, 40126, Bologna, BO, Italy.

Classifications MeSH