Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis.
CD1d
IPF
NASH
NKT cells
fibroblasts
fibrosis
macrophages
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
07
2023
accepted:
06
09
2023
medline:
2
11
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
epublish
Résumé
Chronic tissue inflammation often results in fibrosis characterized by the accumulation of extracellular matrix components remodeling normal tissue architecture and function. Recent studies have suggested common immune mechanisms despite the complexity of the interactions between tissue-specific fibroblasts, macrophages, and distinct immune cell populations that mediate fibrosis in various tissues. Natural killer T (NKT) cells recognizing lipid antigens bound to CD1d molecules have been shown to play an important role in chronic inflammation and fibrosis. Here we review recent data in both experimental models and in humans that suggest a key role of type 1 invariant NKT (iNKT) cell activation in the progression of inflammatory cascades leading to recruitment of neutrophils and activation of the inflammasome, macrophages, fibroblasts, and, ultimately, fibrosis. Emerging evidence suggests that iNKT-associated mechanisms contribute to type 1, type 2 and type 3 immune pathways mediating tissue fibrosis, including idiopathic pulmonary fibrosis (IPF). Thus, targeting a pathway upstream of these immune mechanisms, such as the inhibition of iNKT activation, may be important in modulating various fibrotic conditions.
Identifiants
pubmed: 37818376
doi: 10.3389/fimmu.2023.1260503
pmc: PMC10561218
doi:
Substances chimiques
Antigens, CD1d
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1260503Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA020864
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA100660
Pays : United States
Informations de copyright
Copyright © 2023 Kumar, Hertz, Agro and Byrne.
Déclaration de conflit d'intérêts
VK, MH, and AA are co-founders of GRU Bio and hold equity. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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