Experimental infection of foot and mouth disease virus (FMDV) upregulates the expression of Coxsackie and adenovirus receptor (CAR) in the myocardium of suckling mice.
Coxsackie and adenoviral receptor
Foot and mouth disease virus
Myocarditis
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
11
01
2023
revised:
24
03
2023
accepted:
05
10
2023
medline:
30
10
2023
pubmed:
9
10
2023
entrez:
8
10
2023
Statut:
ppublish
Résumé
The relative overexpression of Coxsackie and adenoviral receptor (CAR) predisposes children to viral myocarditis. As the foot and mouth disease virus (FMDV) causes fatal myocarditis in calves, lambs, and piglets and belongs to the same family as the Coxsackie virus, we investigated the role of CAR in FMDV induced myocarditis in the suckling mice model. Swiss albino suckling mice of 5 days (n = 24) were divided into two equal groups. One group was inoculated with suckling mice adapted FMDV serotype O at 10 LD
Identifiants
pubmed: 37806501
pii: S0882-4010(23)00416-3
doi: 10.1016/j.micpath.2023.106383
pii:
doi:
Substances chimiques
adenovirus receptor
0
Coxsackie and Adenovirus Receptor-Like Membrane Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106383Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.