Smart capsule for monitoring inflammation profile throughout the gastrointestinal tract.

Inflammatory bowel disease Ingestible electronics Oxidation reduction potential Smart capsule Wireless sensing

Journal

Biosensors & bioelectronics: X
ISSN: 2590-1370
Titre abrégé: Biosens Bioelectron X
Pays: Netherlands
ID NLM: 101769237

Informations de publication

Date de publication:
Sep 2023
Historique:
medline: 6 10 2023
pubmed: 6 10 2023
entrez: 6 10 2023
Statut: ppublish

Résumé

Inflammatory bowel disease (IBD) has become alarmingly prevalent in the last two decades affecting 6.8 million people worldwide with a starkly high relapse rate of 40% within 1 year of remission. Existing visual endoscopy techniques rely on subjective assessment of images that are error-prone and insufficient indicators of early-stage IBD, rendering them unsuitable for frequent and quantitative monitoring of gastrointestinal health necessary for detecting regular relapses in IBD patients. To address these limitations, we have implemented a miniaturized smart capsule (2.2 cm × 11 mm) that allows monitoring reactive oxygen species (ROS) levels as a biomarker of inflammation for quantitative and frequent profiling of inflammatory lesions throughout the gastrointestinal tract. The capsule is composed of a pH and oxidation reduction potential (ORP) sensor to track the capsule's location and ROS levels throughout the gastrointestinal tract, respectively, and an optimized electronic interface for wireless sensing and data communication. The designed sensors provided a linear and stable performance within the physiologically relevant range of the GI tract (pH: 1-8 and ORP: -500 to +500 mV). Additionally, systematic design optimization of the wireless interface electronics offered an efficient sampling rate of 10 ms for long-running measurements up to 48 h for a complete evaluation of the entire gastrointestinal tract. As a proof-of-concept, the capsule the capsule's performance in detecting inflammation risks was validated by conducting tests on in vitro cell culture conditions, simulating healthy and inflamed gut-like environments. The capsule presented here achieves a new milestone in addressing the emerging need for smart ingestible electronics for better diagnosis and treatment of digestive diseases.

Identifiants

DOI: 10.1016/j.biosx.2023.100380 PMID: 37799507 PMC: PMC10552446
pubmed: 37799507
doi: 10.1016/j.biosx.2023.100380
pmc: PMC10552446
mid: NIHMS1927922
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIDDK NIH HHS
ID : R21 DK128715
Pays : United States

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Sarath Gopalakrishnan (S)

School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.

Rithu Thomas (R)

School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Sotoudeh Sedaghat (S)

Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.
School of Materials Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Akshay Krishnakumar (A)

School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.

Sadid Khan (S)

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

Trevor Meyer (T)

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

Hans Ajieren (H)

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

Sina Nejati (S)

Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.
School of Materials Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Jiangshan Wang (J)

Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.
Department of Agricultural and Biological Engineering, West Lafayette, IN, 47907, USA.

Mohit S Verma (MS)

Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.
Department of Agricultural and Biological Engineering, West Lafayette, IN, 47907, USA.
Weldon School of Biomedical Engineering, West Lafayette, IN, 47907, USA.

Pedro Irazoqui (P)

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

Rahim Rahimi (R)

School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.
School of Materials Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Classifications MeSH