A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens.

Animals Mice Anti-Bacterial Agents / pharmacology Methicillin-Resistant Staphylococcus aureus Cross Infection / prevention & control Anti-Infective Agents / pharmacology Vaccines Immunity, Innate Microbial Sensitivity Tests Drug Resistance, Bacterial

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
04 10 2023
Historique:
medline: 1 11 2023
pubmed: 4 10 2023
entrez: 4 10 2023
Statut: ppublish

Résumé

Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant, nosocomial pathogens that cause health care-associated infections. We developed a protein-free vaccine composed of aluminum hydroxide, monophosphoryl lipid A, and fungal mannan that improved survival and reduced bacterial burden of mice with invasive blood or lung infections caused by methicillin-resistant

Identifiants

DOI: 10.1126/scitranslmed.adf9556 PMID: 37792959 PMC: PMC10947341
pubmed: 37792959
doi: 10.1126/scitranslmed.adf9556
pmc: PMC10947341
mid: NIHMS1968343
doi:

Substances chimiques

Anti-Bacterial Agents 0
Anti-Infective Agents 0
Vaccines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadf9556

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI130060
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI028697
Pays : United States
Organisme : NIAID NIH HHS
ID : R42 AI145759
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139052
Pays : United States
Organisme : NIAID NIH HHS
ID : R42 AI106375
Pays : United States

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Auteurs

Jun Yan (J)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
ORCID: 0000-0001-7509-2067

Travis B Nielsen (TB)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
UC San Diego School of Medicine, University of California San Diego, San Diego, CA 92093, USA.
ORCID: 0000-0003-3366-7912

Peggy Lu (P)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
ORCID: 0000-0002-7950-0731

Yuli Talyansky (Y)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
ORCID: 0000-0003-1899-3664

Matt Slarve (M)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Hernan Reza (H)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
ORCID: 0000-0001-9624-0700

Boris Novakovic (B)

Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC 3052, Australia.
ORCID: 0000-0002-5623-9008

Mihai G Netea (MG)

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.

Ashley E Keller (AE)

AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.
ORCID: 0009-0000-3095-2959

Troy Warren (T)

AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.

Antonio DiGiandomenico (A)

AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.
ORCID: 0000-0003-1745-647X

Bret R Sellman (BR)

AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.
ORCID: 0000-0002-1172-8799

Brian M Luna (BM)

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
ORCID: 0000-0001-6718-4551

Brad Spellberg (B)

Los Angeles General Medical Center, Los Angeles, CA 90033, USA.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › A protein-free vaccine stimulates innate...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie iatrogène › Infection croisée › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Mélanges complexes › Produits biologiques › Vaccins › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Phénomènes du système immunitaire › Immunité › Immunité innée › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › A protein-free vaccine stimulates innate...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › A protein-free vaccine stimulates innate...