Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy.

DMDmdx rat Duchenne muscular dystrophy age dose study gene therapy mini-dystrophin recombinant adeno-associated virus

Journal

Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857

Informations de publication

Date de publication:
14 Sep 2023
Historique:
received: 29 07 2022
accepted: 15 05 2023
medline: 25 9 2023
pubmed: 25 9 2023
entrez: 25 9 2023
Statut: epublish

Résumé

Duchenne muscular dystrophy (DMD) is an X-linked disease caused by loss-of-function mutations in the

Identifiants

pubmed: 37746247
doi: 10.1016/j.omtm.2023.05.017
pii: S2329-0501(23)00079-7
pmc: PMC10512999
doi:

Types de publication

Journal Article

Langues

eng

Pagination

30-47

Informations de copyright

© 2023 The Authors.

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Auteurs

Caroline Le Guiner (C)

Nantes Université, CHU Nantes, INSERM, TaRGeT, UMR 1089, Translational Research for Gene Therapies, 44200 Nantes, France.

Xiao Xiao (X)

Gene Therapy Center, University of North Carolina, Chapel Hill, NC 27599-7352, USA.

Thibaut Larcher (T)

INRAE Oniris, UMR 703, PanTher, APEX, 44307 Nantes, France.

Aude Lafoux (A)

Therassay Platform, Capacités, Nantes Université, 44007 Nantes, France.

Corinne Huchet (C)

Nantes Université, CHU Nantes, INSERM, TaRGeT, UMR 1089, Translational Research for Gene Therapies, 44200 Nantes, France.
Therassay Platform, Capacités, Nantes Université, 44007 Nantes, France.

Gilles Toumaniantz (G)

Therassay Platform, Capacités, Nantes Université, 44007 Nantes, France.
Nantes Université, CHU Nantes, CNRS, L'Institut du Thorax, 44007 Nantes, France.

Oumeya Adjali (O)

Nantes Université, CHU Nantes, INSERM, TaRGeT, UMR 1089, Translational Research for Gene Therapies, 44200 Nantes, France.

Ignacio Anegon (I)

Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, 44093 Nantes, France.

Séverine Remy (S)

Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, 44093 Nantes, France.

Josh Grieger (J)

Bamboo Therapeutics, Pfizer, Chapel Hill, NC 27514, USA.

Juan Li (J)

Gene Therapy Center, Eshelman School of Pharmacy DPMP, University of North Carolina, Chapel Hill, NC 27599-7352, USA.

Vahid Farrokhi (V)

Pfizer Inc., Andover, MA 01810, USA.

Hendrik Neubert (H)

Pfizer Inc., Andover, MA 01810, USA.

Jane Owens (J)

Pfizer Inc., Cambridge, MA 02139, USA.

Maritza McIntyre (M)

Bamboo Therapeutics, Pfizer, Chapel Hill, NC 27514, USA.

Philippe Moullier (P)

Nantes Université, CHU Nantes, INSERM, TaRGeT, UMR 1089, Translational Research for Gene Therapies, 44200 Nantes, France.

R Jude Samulski (RJ)

Gene Therapy Center, University of North Carolina, Chapel Hill, NC 27599-7352, USA.

Classifications MeSH