A cross-sectional case-control study on the structural connectome in recovered hospitalized COVID-19 patients.

Humans COVID-19 Case-Control Studies Connectome Cross-Sectional Studies Quality of Life

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
21 09 2023
Historique:
received: 02 05 2023
accepted: 10 09 2023
medline: 25 9 2023
pubmed: 22 9 2023
entrez: 22 9 2023
Statut: epublish

Résumé

COVID-19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness's impact on structural brain connectivity, white-matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross-sectional study aimed to investigate differences in these factors between former hospitalised COVID-19 patients (COV) and healthy controls. Group differences in structural brain connectivity were explored using Welch-two sample t-tests and two-sample Mann-Whitney U tests. Multivariate linear models were constructed (one per region) to examine fixel-based group differences. Differences in cognitive performance between groups were investigated using Wilcoxon Rank Sum tests. Possible effects of bundle-specific FD measures on cognitive performance were explored using a two-group path model. No differences in whole-brain structural organisation were found. Bundle-specific metrics showed reduced fiber density (p = 0.012, Hedges' g = 0.884) and fiber density cross-section (p = 0.007, Hedges' g = 0.945) in the motor segment of the corpus callosum in COV compared to healthy controls. Cognitive performance on the motor praxis and digit symbol substitution tests was worse in COV than healthy controls (p < 0.001, r = 0.688; p = 0.013, r = 422, respectively). Associations between the cognitive performance and bundle-specific FD measures differed significantly between groups. WMM and cognitive performance differences were observed between COV and healthy controls.

Identifiants

DOI: 10.1038/s41598-023-42429-y PMID: 37735584 PMC: PMC10514277
pubmed: 37735584
doi: 10.1038/s41598-023-42429-y
pii: 10.1038/s41598-023-42429-y
pmc: PMC10514277
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15668

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Elke Lathouwers (E)

Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0003-0117-8356

Ahmed Radwan (A)

Department of Imaging and Pathology, Translational MRI, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-4819-548X

Jeroen Blommaert (J)

Department of Oncology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-4746-9688

Lara Stas (L)

Biostatistics and Medical Informatics Research Group, Faculty of Medicine and Pharmacy, Department of Public Health, Vrije Universiteit Brussel, Brussels, Belgium.
Core Facility-Support for Quantitative and Qualitative Research (SQUARE), Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0003-1567-2881

Bruno Tassignon (B)

Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0003-3216-4045

Sabine D Allard (SD)

Infectious Diseases Unit, Department of Internal Medicine, UZ Brussel, Jette, Belgium.
ORCID: 0000-0002-1565-7318

Filip De Ridder (F)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.

Elisabeth De Waele (E)

Intensive Care Unit, UZ Brussel, Jette, Belgium.

Nicole Hoornaert (N)

Infectious Diseases Unit, Department of Internal Medicine, UZ Brussel, Jette, Belgium.

Patrick Lacor (P)

Infectious Diseases Unit, Department of Internal Medicine, UZ Brussel, Jette, Belgium.

Rembert Mertens (R)

Infectious Diseases Unit, Department of Internal Medicine, UZ Brussel, Jette, Belgium.

Maarten Naeyaert (M)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.
ORCID: 0000-0002-7452-5534

Hubert Raeymaekers (H)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.
ORCID: 0000-0003-0041-6359

Lucie Seyler (L)

Infectious Diseases Unit, Department of Internal Medicine, UZ Brussel, Jette, Belgium.
ORCID: 0000-0003-3559-6847

Anne-Marie Vanbinst (AM)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.

Lien Van Liedekerke (L)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.

Jeroen Van Schependom (J)

Artificial Intelligence and Modelling in Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium.
Department of Electronics and Informatics (ETRO), Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0003-1200-5872

Peter Van Schuerbeek (P)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.
ORCID: 0000-0003-3647-4446

Steven Provyn (S)

Department of Anatomical Research and Clinical Studies (ARCS), Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0002-2588-2463

Bart Roelands (B)

Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0002-2808-044X

Marie Vandekerckhove (M)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.
Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Faculty of Medicine and Pharmaceutical Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Faculty of Arts and Philosophy, University of Ghent, Ghent, Belgium.

Romain Meeusen (R)

Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
BruBotics, Vrije Universiteit Brussel, Brussels, Belgium.
Strategic Research Program 'Exercise and the Brain in Health & Disease: The Added Value of Human-Centered Robotics', Vrije Universiteit Brussel, Brussels, Belgium.

Stefan Sunaert (S)

Department of Imaging and Pathology, Translational MRI, KU Leuven, Leuven, Belgium.
Department of Radiology, UZ Leuven, Leuven, Belgium.
ORCID: 0000-0002-1177-4680

Guy Nagels (G)

Artificial Intelligence and Modelling in Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium.

Johan De Mey (J)

Department of Radiology and Magnetic Resonance, UZ Brussel, Brussels, Belgium.

Kevin De Pauw (K)

Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium. Kevin.De.Pauw@vub.be.
BruBotics, Vrije Universiteit Brussel, Brussels, Belgium. Kevin.De.Pauw@vub.be.
Strategic Research Program 'Exercise and the Brain in Health & Disease: The Added Value of Human-Centered Robotics', Vrije Universiteit Brussel, Brussels, Belgium. Kevin.De.Pauw@vub.be.
ORCID: 0000-0002-6901-7199

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