Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.
Journal
Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
11
06
2023
accepted:
18
09
2023
pmc-release:
01
12
2024
medline:
16
11
2023
pubmed:
22
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
Scaling factors are necessary for translating in vitro drug biotransformation data to in vivo clearance values in physiologically-based pharmacokinetic modeling and simulation. Values for microsomal protein per gram of liver are available from several sources for use as a scaling factor to estimate hepatic clearance from microsomal drug biotransformation data. However, data regarding the distribution of cytosolic protein per gram of liver (CPPGL) values across the lifespan are limited, and sparse pediatric data have been published to date. Thus, CPPGL was determined in 160 liver samples from pediatric (
Identifiants
pubmed: 37735064
pii: dmd.123.001417
doi: 10.1124/dmd.123.001417
pmc: PMC10658907
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1578-1582Subventions
Organisme : NICHD NIH HHS
ID : P50 HD090258
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002367
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275200900011C
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH130728
Pays : United States
Organisme : NIDDK NIH HHS
ID : HHSN267200700004C
Pays : United States
Organisme : NLM NIH HHS
ID : HHSN267200700004G
Pays : United States
Informations de copyright
Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.
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