Online preconcentration and chiral separation of ofloxacin in exhaled breath condensate by capillary electrophoresis.
Capillary zone electrophoresis
Enantioseparation
Exhaled breath condensate
Ofloxacin
Online preconcentration
Vancomycin
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
25 Oct 2023
25 Oct 2023
Historique:
received:
28
06
2023
revised:
09
08
2023
accepted:
10
08
2023
medline:
11
9
2023
pubmed:
31
8
2023
entrez:
30
8
2023
Statut:
ppublish
Résumé
Breath analysis is an effective method of monitoring systemic or respiratory ailments. A simple chiral capillary electrophoresis method coupled with an online field-amplified sample injection stacking method is presented for ultratrace quantification of the enantiomers of ofloxacin in exhaled breath condensate (EBC). The study is focused on the use of EBC as an easily available biological sample to monitor ofloxacin's enantiomers levels with good patient compliance. The proposed method was validated in accordance with FDA guidelines over the concentration range of 0.004-1.0 µg mL
Identifiants
pubmed: 37647795
pii: S0731-7085(23)00410-7
doi: 10.1016/j.jpba.2023.115641
pii:
doi:
Substances chimiques
Ofloxacin
A4P49JAZ9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115641Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no relevant financial or non-financial interests to disclose.