Pharmacological Nephroprotection in Non-Diabetic Chronic Kidney Disease-Clinical Practice Position Statement of the Polish Society of Nephrology.
Fabry disease
angiotensin II receptor blockers
angiotensin-converting enzyme inhibitors
autosomal-dominant polycystic kidney disease
blood pressure control
chronic kidney disease
metabolic acidosis
renin–angiotensin system
sodium–glucose co-transporter type 2 inhibitors
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
received:
10
07
2023
revised:
03
08
2023
accepted:
07
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is a modern epidemic worldwide. Introducing renin-angiotensin system (RAS) inhibitors (i.e., ACEi or ARB) not only as blood-pressure-lowering agents, but also as nephroprotective drugs with antiproteinuric potential was a milestone in the therapy of CKD. For decades, this treatment remained the only proven strategy to slow down CKD progression. This situation changed some years ago primarily due to the introduction of drugs designed to treat diabetes that turned into nephroprotective strategies not only in diabetic kidney disease, but also in CKD unrelated to diabetes. In addition, several drugs emerged that precisely target the pathogenetic mechanisms of particular kidney diseases. Finally, the role of metabolic acidosis in CKD progression (and not only the sequelae of CKD) came to light. In this review, we aim to comprehensively discuss all relevant therapies that slow down the progression of non-diabetic kidney disease, including the lowering of blood pressure, through the nephroprotective effects of ACEi/ARB and spironolactone independent from BP lowering, as well as the role of sodium-glucose co-transporter type 2 inhibitors, acidosis correction and disease-specific treatment strategies. We also briefly address the therapies that attempt to slow down the progression of CKD, which did not confirm this effect. We are convinced that our in-depth review with practical statements on multiple aspects of treatment offered to non-diabetic CKD fills the existing gap in the available literature. We believe that it may help clinicians who take care of CKD patients in their practice. Finally, we propose the strategy that should be implemented in most non-diabetic CKD patients to prevent disease progression.
Identifiants
pubmed: 37629226
pii: jcm12165184
doi: 10.3390/jcm12165184
pmc: PMC10455736
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Clin Kidney J. 2022 Jan 31;15(7):1275-1283
pubmed: 35756735
Adv Chronic Kidney Dis. 2022 Jul;29(4):329-336
pubmed: 36175070
Nephrol Dial Transplant. 2022 Apr 25;37(5):825-839
pubmed: 35134221
Mol Genet Metab. 2023 Jul;139(3):107603
pubmed: 37236007
Clin Nephrol. 2002 Dec;58(6):405-10
pubmed: 12508961
Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1542-52
pubmed: 26240299
Pol Arch Intern Med. 2018 Oct 31;128(10):587-593
pubmed: 30207550
Lancet. 2022 Nov 19;400(10365):1788-1801
pubmed: 36351458
Adv Chronic Kidney Dis. 2015 Jul;22(4):297-305
pubmed: 26088074
J Am Soc Nephrol. 2009 Sep;20(9):2075-84
pubmed: 19608703
BMC Nephrol. 2017 Jan 11;18(1):14
pubmed: 28077085
Nephrol Dial Transplant. 2022 Aug 22;37(9):1647-1656
pubmed: 34850160
Kidney Med. 2022 Dec 27;5(3):100596
pubmed: 36698747
J Am Soc Nephrol. 2007 Jun;18(6):1889-98
pubmed: 17494885
Hypertension. 2015 Feb;65(2):299-305
pubmed: 25421982
Nat Rev Nephrol. 2022 Nov;18(11):696-707
pubmed: 36104509
Kidney Int. 1998 Nov;54(5):1570-80
pubmed: 9844133
Sci Rep. 2023 Apr 7;13(1):5727
pubmed: 37029191
Eur Heart J. 2022 Feb 10;43(6):474-484
pubmed: 35023547
Kidney Int. 2016 Dec;90(6):1184-1190
pubmed: 27653840
Am J Kidney Dis. 2010 Mar;55(3):441-51
pubmed: 19962808
N Engl J Med. 2020 Oct 8;383(15):1436-1446
pubmed: 32970396
J Hypertens. 1995 Dec;13(12 Pt 1):1363-75
pubmed: 8866898
J Clin Hypertens (Greenwich). 2012 Jan;14(1):32-7
pubmed: 22235821
Circulation. 2021 Jan 26;143(4):310-321
pubmed: 33095032
J Am Soc Nephrol. 2007 Oct;18(10):2766-72
pubmed: 17804673
Nephrol Dial Transplant. 2021 Feb 20;36(3):381-384
pubmed: 32980869
Am J Kidney Dis. 2019 Aug;74(2):263-275
pubmed: 31036389
J Am Soc Nephrol. 1996 Feb;7(2):306-13
pubmed: 8785401
Lancet. 2005 Mar 12-18;365(9463):939-46
pubmed: 15766995
Drug Healthc Patient Saf. 2022 Sep 08;14:147-159
pubmed: 36105663
BMC Nephrol. 2016 Sep 08;17(1):127
pubmed: 27609359
J Am Soc Nephrol. 2021 Sep;32(9):2352-2361
pubmed: 34272327
Drugs. 2019 Feb;79(3):303-313
pubmed: 30689194
Eur Heart J. 2021 Mar 31;42(13):1216-1227
pubmed: 33792669
Int J Mol Sci. 2022 Oct 13;23(20):
pubmed: 36293076
N Engl J Med. 2020 Oct 8;383(15):1413-1424
pubmed: 32865377
Kidney Int. 2014 Nov;86(5):1031-8
pubmed: 24694986
J Hypertens. 2020 Nov;38(11):2110-2121
pubmed: 32649622
Nephrol Dial Transplant. 2001 May;16(5):961-6
pubmed: 11328901
Herz. 2018 Sep;43(6):518-528
pubmed: 28835982
Am J Kidney Dis. 2013 Oct;62(4):670-8
pubmed: 23489677
Int J Mol Sci. 2021 Sep 18;22(18):
pubmed: 34576247
Nutrients. 2022 Jul 22;14(15):
pubmed: 35893866
Pol Arch Intern Med. 2020 Jan 31;130(1):91-97
pubmed: 31868861
J Nephrol. 2019 Dec;32(6):989-1001
pubmed: 31598912
Semin Nephrol. 2007 Sep;27(5):565-71
pubmed: 17868794
Clin J Am Soc Nephrol. 2011 Jan;6(1):50-62
pubmed: 20876671
Am J Kidney Dis. 2020 Jan;75(1 Suppl 1):A6-A7
pubmed: 31704083
N Engl J Med. 2022 Dec 1;387(22):2021-2032
pubmed: 36326117
Adv Ther. 2021 Oct;38(10):5238-5252
pubmed: 34471991
CMAJ. 2013 Aug 6;185(11):949-57
pubmed: 23798459
J Am Soc Nephrol. 2021 Feb;32(2):424-435
pubmed: 33372009
J Am Soc Nephrol. 2012 Aug;23(8):1407-15
pubmed: 22822075
Lancet. 2015 Nov 21;386(10008):2059-2068
pubmed: 26414968
Cochrane Database Syst Rev. 2015 Feb 18;(2):CD010070
pubmed: 25691262
N Engl J Med. 2019 Jul 18;381(3):243-251
pubmed: 31314968
J Clin Invest. 1975 Aug;56(2):414-9
pubmed: 1150879
Lancet. 2008 Aug 16;372(9638):547-53
pubmed: 18707986
N Engl J Med. 2006 Jan 12;354(2):131-40
pubmed: 16407508
Am J Clin Nutr. 2002 Dec;76(6):1308-16
pubmed: 12450898
Pediatr Nephrol. 2019 Jun;34(6):975-991
pubmed: 30105414
Kidney Int. 2020 Jan;97(1):42-61
pubmed: 31706619
Front Pharmacol. 2022 Oct 26;13:1025740
pubmed: 36386210
Am J Kidney Dis. 2016 May;67(5):728-41
pubmed: 26597926
Antioxidants (Basel). 2021 Oct 23;10(11):
pubmed: 34829540
Diabetologia. 2022 Dec;65(12):1925-1966
pubmed: 36151309
Mol Genet Metab. 2022 Sep-Oct;137(1-2):49-61
pubmed: 35926321
Lancet. 1997 Jun 28;349(9069):1857-63
pubmed: 9217756
Am J Med. 1976 Nov;61(5):739-47
pubmed: 984072
Cochrane Database Syst Rev. 2020 Oct 27;10:CD007004
pubmed: 33107592
Clin J Am Soc Nephrol. 2006 Mar;1(2):256-62
pubmed: 17699214
Drugs. 2019 Apr;79(5):543-554
pubmed: 30875019
Kidney Int Suppl (2011). 2017 Jul;7(1):1-59
pubmed: 30675420
Clin J Am Soc Nephrol. 2013 Mar;8(3):371-81
pubmed: 23393104
Am J Kidney Dis. 2005 Dec;46(6):1074-9
pubmed: 16310573
Kidney Int. 2012 Jan;81(1):86-93
pubmed: 21881553
Nephrol Dial Transplant. 2023 Mar 31;38(4):858-875
pubmed: 36413468
Biomedicines. 2021 Apr 24;9(5):
pubmed: 33923349
N Engl J Med. 2023 Jan 12;388(2):117-127
pubmed: 36331190
J Am Soc Nephrol. 2016 Apr;27(4):1202-12
pubmed: 26382905
N Engl J Med. 2019 Jun 13;380(24):2295-2306
pubmed: 30990260
Am J Med. 2021 Sep;134(9):1148-1154
pubmed: 33974908
Ann Intern Med. 1997 Sep 1;127(5):337-45
pubmed: 9273824
Lancet. 2010 Apr 3;375(9721):1173-81
pubmed: 20170948
Adv Chronic Kidney Dis. 2013 Mar;20(2):141-9
pubmed: 23439373
Am J Med. 2017 Jun;130(6):707-719.e8
pubmed: 28109971
J Nephrol. 2012 Nov-Dec;25(6):900-10
pubmed: 22684647
Circulation. 2022 May 10;145(19):1460-1470
pubmed: 35394821
Clin J Am Soc Nephrol. 2021 Aug;16(8):1278-1280
pubmed: 33879500
Int J Nephrol. 2022 Aug 22;2022:9457440
pubmed: 36045900
Hypertens Res. 2003 Jul;26(7):583-9
pubmed: 12924627
Nephrol Dial Transplant. 2013 May;28(5):1207-13
pubmed: 23348878
Lancet. 2020 Sep 19;396(10254):819-829
pubmed: 32877652
N Engl J Med. 2006 Jun 8;354(23):2473-83
pubmed: 16760447
Arch Intern Med. 2004 Mar 22;164(6):659-63
pubmed: 15037495
J Hypertens. 1990 Jul;8(7):663-70
pubmed: 2168457
Nephron Physiol. 2003 Jan;93(1):P3-13
pubmed: 12411725
Kidney Int. 2022 Nov;102(5S):S1-S127
pubmed: 36272764
PLoS One. 2016 Jul 06;11(7):e0158765
pubmed: 27383068
Hypertension. 2022 Jan;79(1):4-11
pubmed: 34784720
Kidney Int. 2006 Dec;70(11):1905-13
pubmed: 17021610
J Am Coll Cardiol. 2007 Aug 14;50(7):563-72
pubmed: 17692739
J Am Soc Nephrol. 2003 Nov;14(11):2990-1
pubmed: 14569113
Eur J Pharmacol. 2021 Dec 5;912:174583
pubmed: 34678238
J Am Soc Nephrol. 2022 Aug;33(8):1569-1580
pubmed: 35440501
J Clin Med. 2022 Aug 17;11(16):
pubmed: 36013057
Nephrol Dial Transplant. 2010 Dec;25(12):3977-82
pubmed: 19820248
Diabetologia. 2022 Jul;65(7):1085-1097
pubmed: 35445820
J Intern Med. 2018 Mar;283(3):314-327
pubmed: 29044764
Ren Fail. 2016;38(2):171-5
pubmed: 26643776
Lancet. 2020 Feb 29;395(10225):709-733
pubmed: 32061315
Front Neurol. 2020 May 27;11:356
pubmed: 32536899
Am J Kidney Dis. 2008 Sep;52(3):486-93
pubmed: 18423812
Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):399-405
pubmed: 35894273
Kidney Int. 2021 Jul;100(1):215-224
pubmed: 33878338
Kidney Int. 1994 Mar;45(3):861-7
pubmed: 8196289
N Engl J Med. 1996 Apr 11;334(15):939-45
pubmed: 8596594
Kidney Res Clin Pract. 2019 Jun 30;38(2):141-144
pubmed: 31189220
Am J Kidney Dis. 2018 Jun;71(6):769-771
pubmed: 29501264
J Am Soc Nephrol. 2023 Mar 1;34(3):385-393
pubmed: 36735510
N Engl J Med. 2021 Oct 14;385(16):1451-1461
pubmed: 34449189
Circulation. 2004 Dec 14;110(24):3667-73
pubmed: 15569840
Am J Kidney Dis. 2013 Aug;62(2):267-75
pubmed: 23601954
Lancet. 2012 Mar 3;379(9818):815-22
pubmed: 22386035
N Engl J Med. 1992 Dec 31;327(27):1912-8
pubmed: 1454086
Am Heart J. 2013 May;165(5):655-64, 664.e1-5
pubmed: 23622902
Eur Heart J. 2021 Sep 21;42(36):3599-3726
pubmed: 34447992
N Engl J Med. 2021 Dec 9;385(24):2252-2263
pubmed: 34449181
J Am Soc Nephrol. 2005 Oct;16(10):3081-91
pubmed: 16135776
Nephrology (Carlton). 2014 Oct;19(10):648-54
pubmed: 25066359
Healthcare (Basel). 2023 Feb 04;11(4):
pubmed: 36832983
Kidney Int. 2015 Jul;88(1):178-85
pubmed: 25786102
Eur Heart J. 2018 Sep 1;39(33):3021-3104
pubmed: 30165516
Hypertension. 1993 Jun;21(6 Pt 1):810-5
pubmed: 8500862
BMJ. 2011 Jul 26;343:d4366
pubmed: 21791491
Lancet. 2011 Jun 25;377(9784):2181-92
pubmed: 21663949
N Engl J Med. 2019 Nov 21;381(21):1995-2008
pubmed: 31535829
Hypertens Res. 2001 Jul;24(4):359-63
pubmed: 11510747
High Blood Press Cardiovasc Prev. 2022 Mar;29(2):125-135
pubmed: 34910287
Kidney Dis (Basel). 2021 Jun 04;7(6):452-467
pubmed: 34901192
Kidney Blood Press Res. 2020;45(6):863-872
pubmed: 33070125
Am J Nephrol. 2002 Jul-Aug;22(4):356-62
pubmed: 12169868
Diabetes Obes Metab. 2021 Dec;23(12):2632-2642
pubmed: 34338408
Ther Clin Risk Manag. 2006 Sep;2(3):297-301
pubmed: 18360604
Clin Hypertens. 2021 Mar 15;27(1):8
pubmed: 33715619
J Am Soc Nephrol. 2011 Dec;22(12):2322-31
pubmed: 21965377
JAMA. 2002 Nov 20;288(19):2421-31
pubmed: 12435255
J Am Soc Hypertens. 2016 Apr;10(4):288-9
pubmed: 26987648
N Engl J Med. 1998 Aug 6;339(6):387-95
pubmed: 9691107
Am J Kidney Dis. 2006 Feb;47(2):263-76
pubmed: 16431255
Nephrol Dial Transplant. 2023 May 31;38(6):1448-1458
pubmed: 36331426
N Engl J Med. 2022 Sep 22;387(12):1089-1098
pubmed: 36027570
Am J Kidney Dis. 2022 Nov;80(5):658-666
pubmed: 36057467
Int J Mol Sci. 2020 Jul 03;21(13):
pubmed: 32635265
JAMA Intern Med. 2020 May 1;180(5):718-726
pubmed: 32150237
J Am Heart Assoc. 2017 Jul 19;6(7):
pubmed: 28724651
Kidney Int. 2002 Sep;62(3):1020-5
pubmed: 12164886
Am J Kidney Dis. 1992 Jul;20(1):18-33
pubmed: 1621675
Front Med (Lausanne). 2021 Dec 07;8:790513
pubmed: 34950686
Lancet. 2013 Jul 20;382(9888):260-72
pubmed: 23727169
Kidney Int. 2017 Mar;91(3):683-690
pubmed: 27927602
Am J Kidney Dis. 2001 Jul;38(1):18-25
pubmed: 11431176
Hypertension. 2018 Apr;71(4):681-690
pubmed: 29463627
Ann Intern Med. 2009 Jul 7;151(1):1-10, W1-2
pubmed: 19451556
Am J Nephrol. 2019;50(5):333-344
pubmed: 31655812
Kidney Int. 2014 Mar;85(3):536-46
pubmed: 24048382
Kidney Int Rep. 2020 Dec 31;6(3):695-705
pubmed: 33732984
J Am Soc Nephrol. 2009 Apr;20(4):893-900
pubmed: 19211712
Lancet. 2012 Nov 10;380(9854):1662-73
pubmed: 23013602
Kidney Res Clin Pract. 2022 Jul;41(4):422-431
pubmed: 35354242
Ann Intern Med. 2001 Apr 17;134(8):629-36
pubmed: 11304102
Kidney Int. 2021 Mar;99(3S):S1-S87
pubmed: 33637192
Lancet. 2008 Oct 18;372(9647):1427-35
pubmed: 18940466
N Engl J Med. 2021 Dec 30;385(27):2507-2519
pubmed: 34739197
Nephrol Dial Transplant. 2020 Oct 1;35(10):1700-1711
pubmed: 32862232
N Engl J Med. 2006 Nov 16;355(20):2071-84
pubmed: 17108342
Curr Neuropharmacol. 2023;21(3):440-456
pubmed: 35652398
J Am Soc Nephrol. 2017 Sep;28(9):2812-2823
pubmed: 28642330
J Am Heart Assoc. 2017 Feb 3;6(2):
pubmed: 28159816
Transplantation. 2022 Sep 1;106(9):e404-e412
pubmed: 35768908
J Am Soc Nephrol. 2022 Nov;33(11):2094-2107
pubmed: 35977807
Circulation. 2006 Jul 4;114(1):26-31
pubmed: 16801465
Blood Press. 2019 Dec;28(6):358-374
pubmed: 31392910
N Engl J Med. 2008 Dec 4;359(23):2417-28
pubmed: 19052124
Transplant Rev (Orlando). 2023 Jan;37(1):100729
pubmed: 36427372
N Engl J Med. 2015 Nov 26;373(22):2103-16
pubmed: 26551272