Trends in Outcomes of Major Intracerebral Haemorrhage in a National Cohort of Very Preterm Born Infants in Switzerland.

grade 3 intraventricular haemorrhage major intraventricular haemorrhage mortality neurodevelopment outcome periventricular periventricular haemorrhagic infarction preterm infant

Journal

Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936

Informations de publication

Date de publication:
19 Aug 2023
Historique:
received: 26 07 2023
revised: 14 08 2023
accepted: 18 08 2023
medline: 26 8 2023
pubmed: 26 8 2023
entrez: 26 8 2023
Statut: epublish

Résumé

Major brain lesions, such as grade 3 intraventricular haemorrhage (G3-IVH) and periventricular haemorrhagic infarction (PVHI) are among the main predictors for poor neurodevelopment in preterm infants. In the last decades advancements in neonatal care have led to a general decrease in adverse outcomes. To assess trends of mortality and neurodevelopmental impairment (NDI) in a recent Swiss cohort of very preterm infants with grade 3 intraventricular haemorrhage (G3-IVH) and periventricular haemorrhagic infarction (PVHI). In this retrospective population-based cohort study, rates of mortality, and NDI at 2 years corrected age were reported in infants born at 24-29 weeks gestational age (GA) in Switzerland in 2002-2014, with G3-IVH and/or PVHI. Out of 4956 eligible infants, 462 (9%) developed G3-IVH (n = 172) or PVHI (n = 290). The average mortality rates for the two pathologies were 33% (56/172) and 60% (175/290), respectively. In 2002-2014, no change in rates of mortality (G3-IVH, In 2002-2014, rates of mortality and NDI in very preterm born infants with major brain lesions did not change. The significant decrease in mean GA and changing hospital policies over this time span may factor into the interpretation of these results.

Sections du résumé

BACKGROUND BACKGROUND
Major brain lesions, such as grade 3 intraventricular haemorrhage (G3-IVH) and periventricular haemorrhagic infarction (PVHI) are among the main predictors for poor neurodevelopment in preterm infants. In the last decades advancements in neonatal care have led to a general decrease in adverse outcomes.
AIM OBJECTIVE
To assess trends of mortality and neurodevelopmental impairment (NDI) in a recent Swiss cohort of very preterm infants with grade 3 intraventricular haemorrhage (G3-IVH) and periventricular haemorrhagic infarction (PVHI).
METHODS METHODS
In this retrospective population-based cohort study, rates of mortality, and NDI at 2 years corrected age were reported in infants born at 24-29 weeks gestational age (GA) in Switzerland in 2002-2014, with G3-IVH and/or PVHI.
RESULTS RESULTS
Out of 4956 eligible infants, 462 (9%) developed G3-IVH (n = 172) or PVHI (n = 290). The average mortality rates for the two pathologies were 33% (56/172) and 60% (175/290), respectively. In 2002-2014, no change in rates of mortality (G3-IVH,
CONCLUSION CONCLUSIONS
In 2002-2014, rates of mortality and NDI in very preterm born infants with major brain lesions did not change. The significant decrease in mean GA and changing hospital policies over this time span may factor into the interpretation of these results.

Identifiants

DOI: 10.3390/children10081412 PMID: 37628411 PMC: PMC10453192
pubmed: 37628411
pii: children10081412
doi: 10.3390/children10081412
pmc: PMC10453192
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Swiss National Science Foundation
ID : PZOOP3_161146
Pays : Switzerland

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Auteurs

Philip Thwaites (P)

Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.

Cornelia Hagmann (C)

Department of Paediatric and Neonatal Intensive Care, University Children's Hospital Zurich, CH-8032 Zurich, Switzerland.
Children's Research Center, University Children's Hospital Zurich, CH-8032 Zurich, Switzerland.

Juliane Schneider (J)

Woman-Mother-Child Department, Clinic of Neonatology, University Hospital Center, University of Lausanne, CH-1011 Lausanne, Switzerland.
ORCID: 0000-0001-6849-6178

Sven M Schulzke (SM)

Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, CH-4056 Basel, Switzerland.

Sebastian Grunt (S)

Division of Neuropediatrics, Development and Rehabilitation, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland.

Thi Dao Nguyen (TD)

Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.

Dirk Bassler (D)

Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.

Giancarlo Natalucci (G)

Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.
Child Development Centre, University Children's Hospital Zurich, CH-8032 Zurich, Switzerland.
Family Larsson-Rosenquist Foundation Centre for Neurodevelopment, Growth and Nutrition of the Newborn, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland.

Classifications MeSH