A Journey in the Brain's Clock: In Vivo Veritas?
calcium imaging
chronobiology
suprachiasmatic nucleus
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
15 Aug 2023
15 Aug 2023
Historique:
received:
26
07
2023
revised:
12
08
2023
accepted:
14
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
The suprachiasmatic nuclei (SCN) of the hypothalamus contain the circadian pacemaker that coordinates mammalian rhythms in tune with the day-night cycle. Understanding the determinants of the intrinsic rhythmicity of this biological clock, its outputs, and resetting by environmental cues, has been a longstanding goal of the field. Integrated techniques of neurophysiology, including lesion studies and in vivo multi-unit electrophysiology, have been key to characterizing the rhythmic nature and outputs of the SCN in animal models. In parallel, reduced ex vivo and in vitro approaches have permitted us to unravel molecular, cellular, and multicellular mechanisms underlying the pacemaker properties of the SCN. New questions have emerged in recent years that will require combining investigation at a cell resolution within the physiological context of the living animal: What is the role of specific cell subpopulations in the SCN neural network? How do they integrate various external and internal inputs? What are the circuits involved in controlling other body rhythms? Here, we review what we have already learned about the SCN from in vivo studies, and how the recent development of new genetically encoded tools and cutting-edge imaging technology in neuroscience offers chronobiologists the opportunity to meet these challenges.
Identifiants
pubmed: 37627020
pii: biology12081136
doi: 10.3390/biology12081136
pmc: PMC10452196
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fédération pour la Recherche sur le Cerveau
ID : Neurodon 2021
Organisme : National Institute of Health
ID : R35GM136661
Organisme : National Institute of Health
ID : T32HL007901
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