Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.
immunological memory
intrauterine transfer
maternal microchimerism
pregnancy
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
09 Oct 2023
09 Oct 2023
Historique:
revised:
31
07
2023
received:
13
01
2023
accepted:
02
08
2023
pubmed:
23
8
2023
medline:
23
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.
Identifiants
pubmed: 37610043
doi: 10.15252/embr.202356829
pmc: PMC10561172
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e56829Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : FOR5068
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : AR232/29-1(PCA)
Organisme : Deutsche Forschungsgemeinschaft
ID : KFO296
Organisme : Deutsche Forschungsgemeinschaft
ID : AR232/24-2(PCA)
Organisme : Deutsche Forschungsgemeinschaft
ID : MI476/5-2(HWM)
Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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