In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using

Animals Huntington Disease / metabolism Huntingtin Protein / genetics Positron Emission Tomography Computed Tomography Macaca mulatta / metabolism Nerve Tissue Proteins / genetics Positron-Emission Tomography Disease Models, Animal
Huntington disease PET brain mHTT nonhuman primate

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
10 2023
Historique:
received: 07 02 2023
revised: 13 06 2023
medline: 5 10 2023
pubmed: 18 8 2023
entrez: 17 8 2023
Statut: ppublish

Résumé

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine (CAG) trinucleotide expansion in the huntingtin (

Identifiants

DOI: 10.2967/jnumed.123.265569 PMID: 37591545 PMC: PMC10586486
pubmed: 37591545
pii: jnumed.123.265569
doi: 10.2967/jnumed.123.265569
pmc: PMC10586486
doi:

Substances chimiques

Huntingtin Protein 0
Nerve Tissue Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1581-1587

Subventions

Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG055378
Pays : United States

Informations de copyright

© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

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Auteurs

Daniele Bertoglio (D)

Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium; daniele.bertoglio@uantwerpen.be weissa@ohsu.edu.
Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Alison R Weiss (AR)

Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon; daniele.bertoglio@uantwerpen.be weissa@ohsu.edu.

William Liguore (W)

Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon.

Lauren Drew Martin (LD)

Division of Animal Resources and Research Support, Oregon National Primate Research Center, Beaverton, Oregon.

Theodore Hobbs (T)

Division of Animal Resources and Research Support, Oregon National Primate Research Center, Beaverton, Oregon.

John Templon (J)

Center for Radiochemistry Research, Oregon Health and Science University, Portland, Oregon.

Sathya Srinivasan (S)

Integrated Pathology Core, Oregon National Primate Research Center, Beaverton, Oregon.

Celia Dominguez (C)

CHDI Management/CHDI Foundation, Los Angeles, California; and.

Ignacio Munoz-Sanjuan (I)

CHDI Management/CHDI Foundation, Los Angeles, California; and.

Vinod Khetarpal (V)

CHDI Management/CHDI Foundation, Los Angeles, California; and.

Jeroen Verhaeghe (J)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Steven Staelens (S)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Jeanne Link (J)

Center for Radiochemistry Research, Oregon Health and Science University, Portland, Oregon.

Longbin Liu (L)

CHDI Management/CHDI Foundation, Los Angeles, California; and.

Jonathan A Bard (JA)

CHDI Management/CHDI Foundation, Los Angeles, California; and.

Jodi L McBride (JL)

Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon.
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie de Huntington › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéine huntingtine › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › In Vivo Cerebral Imaging of Mutant Huntingtin...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › In Vivo Cerebral Imaging of Mutant Huntingtin...