Immunotherapies in MuSK-positive Myasthenia Gravis; an IgG4 antibody-mediated disease.
CAAR-T cells
FcRn
IgG4
MuSK
Myasthenia Gravis
anti-CD20
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
04
2023
accepted:
05
07
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Muscle-specific kinase (MuSK) Myasthenia Gravis (MG) represents a prototypical antibody-mediated disease characterized by predominantly focal muscle weakness (neck, facial, and bulbar muscles) and fatigability. The pathogenic antibodies mostly belong to the immunoglobulin subclass (Ig)G4, a feature which attributes them their specific properties and pathogenic profile. On the other hand, acetylcholine receptor (AChR) MG, the most prevalent form of MG, is characterized by immunoglobulin (Ig)G1 and IgG3 antibodies to the AChR. IgG4 class autoantibodies are impotent to fix complement and only weakly bind Fc-receptors expressed on immune cells and exert their pathogenicity
Identifiants
pubmed: 37564637
doi: 10.3389/fimmu.2023.1212757
pmc: PMC10410455
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulin G
0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Receptors, Cholinergic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1212757Informations de copyright
Copyright © 2023 Vakrakou, Karachaliou, Chroni, Zouvelou, Tzanetakos, Salakou, Papadopoulou, Tzartos, Voumvourakis, Kilidireas, Giannopoulos, Tsivgoulis and Tzartos.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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