European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy.
ischemia-reperfusion injury
islet transplantation
machine perfusion
persufflation
whole pancreas transplantation
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
03
2023
accepted:
03
07
2023
medline:
8
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney's and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the "Role of pancreas machine perfusion to increase the donor pool for beta cell replacement," the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.
Identifiants
pubmed: 37547751
doi: 10.3389/ti.2023.11374
pii: 11374
pmc: PMC10402633
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11374Informations de copyright
Copyright © 2023 Ferrer-Fàbrega, Mesnard, Messner, Doppenberg, Drachenberg, Engelse, Johnson, Leuvenink, Oniscu, Papalois, Ploeg, Reichman, Scott, Vistoli, Berney, Jacobs-Tulleneers-Thevissen, Kessaris, Weissenbacher, Ogbemudia, White and Branchereau.
Déclaration de conflit d'intérêts
JF-F received lecture fees from Bayer and AstraZeneca; consultancy fees from AstraZeneca. JF-F is the recipient of a grant supported by Instituto de Salud Carlos III (ISCIII) through the project “PI18/00161 (Optimization of pancreas transplant graft: A multicentric study of histo-morphological and functional characteristics of unaccepted organs.)” and co-funded by the European Union. BM received grand support from Institut Georges Lopez and the Hémarina Society. RP is an advisor to Bridge to Life Ltd. UK for issues on organ preservation. TR received consultancy fees from Sernova Corp and clinical trial support from Vertex Pharmaceuticals. WS is the co-founder and Chief Scientific Officer of ScubaTx Ltd. JB received logistic help/research grant from Institute Georges Lopez, Organ Revovery System, Hemarina, Bridge to life, and Xvivo. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Transpl Int. 2022 Mar 28;35:10419
pubmed: 35418805
PLoS One. 2021 May 3;16(5):e0251055
pubmed: 33939760
Transplant Proc. 2010 Jul-Aug;42(6):2016-9
pubmed: 20692396
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
Lancet Diabetes Endocrinol. 2017 Jun;5(6):431-437
pubmed: 28365411
Transplant Proc. 2011 Nov;43(9):3398-401
pubmed: 22099806
Am J Transplant. 2021 Sep;21(9):3077-3087
pubmed: 33565712
J Gen Intern Med. 2020 May;35(5):1427-1434
pubmed: 31898135
Curr Opin Organ Transplant. 2016 Aug;21(4):386-92
pubmed: 27096564
Transplantation. 2023 Feb 1;107(2):438-448
pubmed: 35993664
Curr Opin Organ Transplant. 2008 Apr;13(2):135-41
pubmed: 18685293
Curr Opin Organ Transplant. 2018 Jun;23(3):330-335
pubmed: 29634496
Am J Transplant. 2022 Mar;22 Suppl 2:137-203
pubmed: 35266622
Curr Opin Organ Transplant. 2013 Feb;18(1):24-33
pubmed: 23254699
Transpl Int. 2021 Sep;34(9):1630-1642
pubmed: 34448276
Curr Opin Organ Transplant. 2020 Aug;25(4):329-335
pubmed: 32618717
Am J Transplant. 2022 May;22(5):1339-1349
pubmed: 35258859
Clin Transplant. 2010 Jan-Feb;24(1):1-19
pubmed: 20015270
Diabetologia. 2020 Oct;63(10):2049-2056
pubmed: 32894315
Int J Mol Sci. 2021 May 13;22(10):
pubmed: 34068301
Transpl Int. 2019 Jun;32(6):586-597
pubmed: 30980772
Artif Organs. 2018 Mar;42(3):334-335
pubmed: 29516579
Transpl Int. 2022 Oct 24;35:10915
pubmed: 36406781