Pharmacokinetic and Pharmacodynamic Changes in the Elderly: Impact on Anesthetics.

Aging Frailty Pharmacodynamics Pharmacokinetics Physiology Senescence

Journal

Anesthesiology clinics
ISSN: 1932-2275
Titre abrégé: Anesthesiol Clin
Pays: United States
ID NLM: 101273663

Informations de publication

Date de publication:
Sep 2023
Historique:
medline: 31 7 2023
pubmed: 30 7 2023
entrez: 29 7 2023
Statut: ppublish

Résumé

Anesthesiologists are increasingly required to care for frail elderly patients. A detailed knowledge of the influence of age on the pharmacokinetics and dynamics of the anesthetic drugs is essential for optimal safety and care. For most of the anesthetic drugs, the elderly need lower doses to achieve the same plasma concentrations, and at any given plasma and effect-site concentration, they will have more profound clinical effects than younger patients. Caution is required, with close monitoring of clinical effects and active titration of dose administration to achieve the desired level of effect, ideally following the "start low, go slow" principle.

Identifiants

pubmed: 37516494
pii: S1932-2275(23)00006-X
doi: 10.1016/j.anclin.2023.02.006
pii:
doi:

Substances chimiques

Anesthetics 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

549-565

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Ettienne Coetzee (E)

Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital, D23, Observatory, Cape Town 7925, Republic of South Africa.

Anthony Ray Absalom (AR)

Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Post Box 30.001, Groningen 9700 RB, the Netherlands. Electronic address: a.r.absalom@umcg.nl.

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Classifications MeSH