Pharmacokinetic and Pharmacodynamic Changes in the Elderly: Impact on Anesthetics.
Aging
Frailty
Pharmacodynamics
Pharmacokinetics
Physiology
Senescence
Journal
Anesthesiology clinics
ISSN: 1932-2275
Titre abrégé: Anesthesiol Clin
Pays: United States
ID NLM: 101273663
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
31
7
2023
pubmed:
30
7
2023
entrez:
29
7
2023
Statut:
ppublish
Résumé
Anesthesiologists are increasingly required to care for frail elderly patients. A detailed knowledge of the influence of age on the pharmacokinetics and dynamics of the anesthetic drugs is essential for optimal safety and care. For most of the anesthetic drugs, the elderly need lower doses to achieve the same plasma concentrations, and at any given plasma and effect-site concentration, they will have more profound clinical effects than younger patients. Caution is required, with close monitoring of clinical effects and active titration of dose administration to achieve the desired level of effect, ideally following the "start low, go slow" principle.
Identifiants
pubmed: 37516494
pii: S1932-2275(23)00006-X
doi: 10.1016/j.anclin.2023.02.006
pii:
doi:
Substances chimiques
Anesthetics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
549-565Informations de copyright
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