SARS-CoV-2 Antibody Dynamics after COVID-19 Vaccination and Infection: A Real-World Cross-Sectional Analysis.
COVID-19
SARS-CoV-2
anti-RBD
booster
humoral immunity
infection
vaccine
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
18
05
2023
revised:
22
06
2023
accepted:
27
06
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The Coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), continues to surge despite the widespread use of vaccination. In Thailand, more than 77% and 39% of the population received two doses and three doses of COVID-19 vaccines as of December 2022, respectively. In addition, during the Omicron predominant period in 2022, more than 70% of Thai individuals have been infected. To gain comprehensive insight into SARS-CoV-2 antibody dynamics following vaccination or following vaccination and infection (hybrid immunity), we performed a cross-sectional analysis of sera samples from individuals who received COVID-19 vaccination and/or have been infected with COVID-19 in Thailand between January 2021 and December 2022. A total of 4126 samples were collected. Humoral immunity was evaluated by quantifying the immunoglobulin (including IgG, IgM, and IgA isotypes) specific to the SARS-CoV-2 receptor-binding domain (RBD) or Ig anti-RBD. The results showed that individuals who received two-dose vaccination alone had lower levels of Ig anti-RBD, which rapidly waned over time. To restore the waning antibody, a third dose vaccination is recommended for uninfected individuals who have only received 2 doses.
Identifiants
pubmed: 37515001
pii: vaccines11071184
doi: 10.3390/vaccines11071184
pmc: PMC10384814
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Health Systems Research Institute
Organisme : National Research Council of Thailand
Organisme : MK restaurant Group Aunt Thongkum Foundation
Organisme : BJC Big C Foundation
Organisme : the Center of Excellence in Clinical Virology, Chulalongkorn University, and the King Chulalongkorn Memorial Hospital
Organisme : Ratchadapisek Somphot Fund for Postdoctoral Fellowship, Chulalongkorn University
Références
Nat Med. 2022 Mar;28(3):477-480
pubmed: 35046572
Vaccines (Basel). 2023 Mar 01;11(3):
pubmed: 36992154
JAMA Netw Open. 2022 Apr 1;5(4):e229317
pubmed: 35482308
Clin Microbiol Infect. 2022 Apr;28(4):612.e1-612.e7
pubmed: 34826623
J Intern Med. 2023 Jun;293(6):763-781
pubmed: 37024264
Nat Commun. 2022 May 13;13(1):2670
pubmed: 35562366
Hum Vaccin Immunother. 2022 Dec 31;18(1):2029111
pubmed: 35209809
Vaccines (Basel). 2022 Jun 30;10(7):
pubmed: 35891221
J Infect Dis. 2023 May 29;227(11):1255-1265
pubmed: 36780397
Nat Med. 2022 Apr;28(4):831-837
pubmed: 35045566
Vaccine. 2022 May 26;40(24):3320-3329
pubmed: 35513961
J Med Virol. 2022 Dec;94(12):5713-5722
pubmed: 35924475
Nat Med. 2021 Nov;27(11):2032-2040
pubmed: 34588689
Nat Commun. 2022 Mar 28;13(1):1614
pubmed: 35347129
Cochrane Database Syst Rev. 2022 Dec 7;12:CD015477
pubmed: 36473651
Lancet Infect Dis. 2022 Jul;22(7):1002-1010
pubmed: 35405090
J Infect. 2021 Sep;83(3):381-412
pubmed: 34161817
Vaccine. 2015 Jan 29;33(5):742-7
pubmed: 25454853
Hum Vaccin Immunother. 2022 Nov 30;18(6):2091865
pubmed: 35816053
PLoS One. 2020 Sep 29;15(9):e0239729
pubmed: 32991630
Vaccines (Basel). 2022 Mar 03;10(3):
pubmed: 35335023
Vaccines (Basel). 2022 Mar 30;10(4):
pubmed: 35455285
Nature. 2022 Feb;602(7898):676-681
pubmed: 35016198
Vaccine. 2022 Jan 24;40(3):524-530
pubmed: 34893344
N Engl J Med. 2022 Jun 9;386(23):2201-2212
pubmed: 35613036
Lancet Infect Dis. 2022 Jun;22(6):781-790
pubmed: 35366962