A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia (MAINSTREAM): A Study Protocol.
imaging biomarkers
language training
molecular biomarkers
primary progressive aphasia
transcranial Direct Current Stimulation
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
12 Jul 2023
12 Jul 2023
Historique:
received:
11
05
2023
revised:
27
06
2023
accepted:
07
07
2023
medline:
29
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Primary Progressive Aphasia (PPA) is a syndrome due to different neurodegenerative disorders selectively disrupting language functions. PPA specialist care is underdeveloped. There are very few specialists (neurologists, psychiatrists, neuropsychologists, and speech therapists) and few hospital- or community-based services dedicated to the diagnosis and continuing care of people with PPA. Currently, healthcare systems struggle to provide adequate coverage of care that is too often fragmented, uncoordinated, and unresponsive to the needs of people with PPA and their families. Recently, attention has been gained by non-invasive brain stimulation techniques that allow a personalized treatment approach, such as transcranial Direct Current Stimulation (tDCS). The MAINSTREAM trial looks forward to introducing and evaluating therapeutic innovations such as tDCS coupled with language therapy in rehabilitation settings. A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM (ID: 3430931) was registered in the clinicaltrials.gov database (identifier: NCT05730023) on 15 February 2023.
Identifiants
pubmed: 37508992
pii: brainsci13071060
doi: 10.3390/brainsci13071060
pmc: PMC10377301
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT05730023']
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondazione Regionale per la Ricerca Biomedica (FRRB) UNMET MEDICAL NEEDS - Regione Lombardia
ID : Project ID: 3430931
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