Early Development of Atherosclerotic Plaques in the Coronary Arteries after Radiotherapy for Breast Cancer (BACCARAT Study).
breast cancer
contrast-enhanced CT angiography
coronary atherosclerotic plaques
radiotherapy
Journal
Journal of cardiovascular development and disease
ISSN: 2308-3425
Titre abrégé: J Cardiovasc Dev Dis
Pays: Switzerland
ID NLM: 101651414
Informations de publication
Date de publication:
12 Jul 2023
12 Jul 2023
Historique:
received:
15
05
2023
revised:
08
07
2023
accepted:
10
07
2023
medline:
28
7
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
epublish
Résumé
Background-Radiotherapy (RT) for breast cancer (BC) can lead to an increased risk of coronary artery disease several years after RT. The aim of this study was to evaluate the development of overall, non-calcified and calcified atherosclerotic plaques over 2 years after BC for RT and associations with cardiac exposure. Methods-The study included 101 left- or right-sided BC patients treated with RT without chemotherapy. A coronary CT angiography was performed before and 2 years after RT. Plaque development thorough the entire coronary network was defined as an increased number of plaques. Cardiac exposure was quantified with mean doses to the heart, left ventricle, and coronary arteries. Logistic regression models were used to assess association with doses. Results-At inclusion, 37% of patients had plaques, increasing to 42% two years after RT. Overall plaque development was observed in seven patients: five with calcified plaque development and four with non-calcified plaque development. The risk of overall plaque development was significantly associated with doses to the Left Main and Circumflex coronary arteries (OR at 1 Gy = 2.32,
Identifiants
pubmed: 37504555
pii: jcdd10070299
doi: 10.3390/jcdd10070299
pmc: PMC10380516
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02605512']
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fédération Française de Cardiologie (FFC), Electricité de France (EDF) and the H2020 Euratom research and training program 2014-2018 under grant agreement No. 755523 in the frame of the MEDIRAD project.
ID : 755523
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