Understanding the genetic complexity of puberty timing across the allele frequency spectrum.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
20 Jun 2023
Historique:
pubmed: 28 7 2023
medline: 28 7 2023
entrez: 28 7 2023
Statut: epublish

Résumé

Pubertal timing varies considerably and has been associated with a range of health outcomes in later life. To elucidate the underlying biological mechanisms, we performed multi-ancestry genetic analyses in ~800,000 women, identifying 1,080 independent signals associated with age at menarche. Collectively these loci explained 11% of the trait variance in an independent sample, with women at the top and bottom 1% of polygenic risk exhibiting a ~11 and ~14-fold higher risk of delayed and precocious pubertal development, respectively. These common variant analyses were supported by exome sequence analysis of ~220,000 women, identifying several genes, including rare loss of function variants in

Identifiants

DOI: 10.1101/2023.06.14.23291322 PMID: 37503126 PMC: PMC10371120
pubmed: 37503126
doi: 10.1101/2023.06.14.23291322
pmc: PMC10371120
pii:
doi:

Types de publication

Preprint

Langues

eng

Déclaration de conflit d'intérêts

Competing interests J.R.B.P. and E.J.G. are employed by Adrestia Therapeutics. D.J.T. is employed by Genomics PLC. D.L.C. and J.P.B. are employed by GSK. E.T. is employed by Pfizer. D.A.L. has received support from Roche Disgnostics and Medtroic Ltd for work unrelated to the research in this paper. T.D.S. is co-founder and stakeholder of Zoe Global Ltd. P.A.F. conducts research funded by Amgen, Novartis and Pfizer, he received Honoraria from Roche, Novartis and Pfizer. M.W.B. conducts research funded by Amgen, Novartis and Pfizer.

Auteurs

Katherine A Kentistou (KA)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Lena R Kaisinger (LR)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Stasa Stankovic (S)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Marc Vaudel (M)

Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.
Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, NO-0213, Oslo, Norway.

Edson M de Oliveira (EM)

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Andrea Messina (A)

Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, 1011 Lausanne, Switzerland.

Robin G Walters (RG)

Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
MRC Population Health Research Unit, University of Oxford, Oxford OX3 7LF, UK.

Xiaoxi Liu (X)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Alexander S Busch (AS)

Department of General Pediatrics, University of Münster, Münster, Germany.
Deptartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Hannes Helgason (H)

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.

Deborah J Thompson (DJ)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

Federico Santon (F)

Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, 1011 Lausanne, Switzerland.

Konstantin M Petricek (KM)

Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Berlin, Germany.

Yassine Zouaghi (Y)

Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, 1011 Lausanne, Switzerland.

Isabel Huang-Doran (I)

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Daniel F Gudbjartsson (DF)

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.

Eirik Bratland (E)

Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.
Department of Medical Genetics, Haukeland University Hospital, NO-5021, Bergen, Norway.

Kuang Lin (K)

Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Eugene J Gardner (EJ)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Yajie Zhao (Y)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Raina Jia (R)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Chikashi Terao (C)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.
The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

Margie Riggan (M)

Department of Gynecology, Duke University Medical Center, Durham, North Carolina, USA.

Manjeet K Bolla (MK)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

Mojgan Yazdanpanah (M)

Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada.

Nahid Yazdanpanah (N)

Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada.

Jonath P Bradfield (JP)

Quantinuum Research, Wayne, PA, USA.
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Linda Broer (L)

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Archie Campbell (A)

Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.

Daniel I Chasman (DI)

Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Diana L Cousminer (DL)

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Nora Franceschini (N)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Lude H Franke (LH)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Giorgia Girotto (G)

Institute for Maternal and Child Health - IRCCS ''Burlo Garofolo", Trieste, Italy.
Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Chunyan He (C)

Department of Epidemiology and Biostatistics, Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Departments of Medical Oncology and Hematology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.

Marjo-Riitta Järvelin (MR)

Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.
Institute of Health Sciences, P.O.Box 5000, FI-90014 University of Oulu, Finland.
Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.
Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland.
Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland.

Peter K Joshi (PK)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.

Yoichiro Kamatani (Y)

Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Robert Karlsson (R)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Jian'an Luan (J)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Kathryn L Lunetta (KL)

Boston University School of Public Health, Department of Biostatistics. Boston, Massachusetts 02118, USA.
NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.

Reedik Mägi (R)

Institute of Genomics, University of Tartu, Tartu, Estonia.

Massimo Mangino (M)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.

Sarah E Medland (SE)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
School of Psychology, University of Queensland, Brisbane, Queensland, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Christa Meisinger (C)

Epidemiology, Medical Faculty, University of Augsburg, University Hospital of Augsburg, Augsburg, Germany.

Raymond Noordam (R)

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

Teresa Nutile (T)

Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.

Maria Pina Concas (MP)

Institute for Maternal and Child Health - IRCCS ''Burlo Garofolo", Trieste, Italy.

Ozren Polašek (O)

University of Split School of Medicine, Split, Croatia.
Algebra University College, Zagreb, Croatia.

Eleonora Porcu (E)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy.
University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy.

Susan M Ring (SM)

MRC Integrative Epidemiology Unit at the University of Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, UK.

Cinzia Sala (C)

Division of Genetics and Cell Biology, San Raffele Hospital, Milano, Italy.

Albert V Smith (AV)

Icelandic Heart Association, 201 Kopavogur, Iceland.
Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.

Toshiko Tanaka (T)

National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.

Peter J van der Most (PJ)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.

Veronique Vitart (V)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.

Carol A Wang (CA)

School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales 2308, Australia.
Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia.

Gonneke Willemsen (G)

Dept of Biological Psychology, Vrije Universiteit, Amsterdam; Amsterdam Public Health (APH) research institute, The Netherlands.

Marek Zygmunt (M)

Clinic of Gynaecology and Obstetrics, University Medicine Greifswald, Germany.

Thomas U Ahearn (TU)

Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, USA.

Irene L Andrulis (IL)

Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Toronto, Ontario, Canada.
Department of Molecular Genetics University of Toronto Toronto, Ontario, Canada.

Hoda Anton-Culver (H)

Department of Medicine, Genetic Epidemiology Research Institute University of California Irvine Irvine, CA, USA.

Antonis C Antoniou (AC)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

Paul L Auer (PL)

Division of Biostatistics, Institute for Health and Equity, and Cancer Center Medical College of Wisconsin Milwaukee, WI, USA.

Catriona Lk Barnes (CL)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.

Amy Berrington (A)

Division of Genetics and Epidemiology The Institute of Cancer Research, London, UK.

Natalia V Bogdanova (NV)

Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.

Stig E Bojesen (SE)

Copenhagen General Population Study, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ), Heidelberg, Germany.

Julie E Buring (JE)

Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Federico Canzian (F)

Genomic Epidemiology Group German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH) University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Fergus J Couch (FJ)

Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, MN, USA.

Angela Cox (A)

Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Laura Crisponi (L)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy.

Kamila Czene (K)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Mary B Daly (MB)

Department of Clinical Genetics Fox Chase Cancer Center Philadelphia, PA, USA.

Ellen W Demerath (EW)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, USA.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

Peter Devilee (P)

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Immaculata De Vivo (I)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Thilo Dörk (T)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Alison M Dunning (AM)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Miriam Dwek (M)

School of Life Sciences, University of Westminster, London, UK.

Johan G Eriksson (JG)

Department of General Practice and Primary Healthcare, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.

Lindsay Fernandez-Rhodes (L)

Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.

Liana Ferreli (L)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy.

Olivia Fletcher (O)

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

Manuela Gago-Dominguez (M)

Genomic Medicine Group, International Cancer Genetics and Epidemiology Group Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS Santiago de Compostela, Spain.

Montserrat García-Closas (M)

Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, USA.

José A García-Sáenz (JA)

Medical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

Anna González-Neira (A)

Human Genotyping Unit-CeGen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Harald Grallert (H)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.

Pascal Guénel (P)

Team "Exposome and Heredity", CESP, Gustave Roussy INSERM, University Paris-Saclay, UVSQ Villejuif, France.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Per Hall (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Oncology, Södersjukhuset, Stockholm, Sweden.

Ute Hamann (U)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Hakon Hakonarson (H)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Roger J Hart (RJ)

Division of Obstetrics and Gynaecology, University of Western Australia, Western Australia, Australia.

Martha Hickey (M)

Department of Obstetrics and Gynaecology at the University of Melbourne and The Royal Women's Hospital, Victoria, Australia.

Maartje J Hooning (MJ)

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Reiner Hoppe (R)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
University of Tübingen, Tübingen, Germany.

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne Melbourne, Victoria, Australia.

Jouke-Jan Hottenga (JJ)

Dept of Biological Psychology, Vrije Universiteit, Amsterdam; Amsterdam Public Health (APH) research institute, The Netherlands.

Frank B Hu (FB)

Department of Nutrition, Harvard T.H. Chan School of Public Health School of Public Health, Boston, Massachusetts 02115, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Hanna Hübner (H)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.

David J Hunter (DJ)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Helena Jernström (H)

Oncology, Department of Clinical Sciences in Lund, Lund University, Lund, Sweden.

Esther M John (EM)

Department of Epidemiology and Population Health, Stanford University School of Medicine Stanford, CA, USA.
Department of Medicine, Division of Oncology Stanford Cancer Institute, Stanford University School of Medicine Stanford, CA, USA.

David Karasik (D)

Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Elza K Khusnutdinova (EK)

Institute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.

Vessela N Kristensen (VN)

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

James V Lacey (JV)

Department of Computational and Quantitative Medicine, City of Hope Duarte, CA, USA.
City of Hope Comprehensive Cancer Center, City of Hope Duarte, CA, USA.

Diether Lambrechts (D)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
VIB Center for Cancer Biology, VIB, Leuven, Belgium.

Lenore J Launer (LJ)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Penelope A Lind (PA)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Annika Lindblom (A)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.

Patrik Ke Magnusson (PK)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Arto Mannermaa (A)

Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.

Mark I McCarthy (MI)

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK.

Thomas Meitinger (T)

Institute of Human Genetics, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

Cristina Menni (C)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Kyriaki Michailidou (K)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Biostatistics Unit, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.

Iona Y Millwood (IY)

Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
MRC Population Health Research Unit, University of Oxford, Oxford OX3 7LF, UK.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne Melbourne, Victoria, Australia.

Grant W Montgomery (GW)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Heli Nevanlinna (H)

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Ilja M Nolte (IM)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Dale R Nyholt (DR)

School of Biomedical Sciences, Faculty of Health, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Queensland, Australia.

Nadia Obi (N)

Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Katie M O'Brien (KM)

Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park, NC, USA.

Kenneth Offit (K)

Clinical Genetics Research Lab, Department of Cancer Biology and Genetics Memorial Sloan Kettering Cancer Center New York, NY, USA.
Clinical Genetics Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, NY, USA.

Albertine J Oldehinkel (AJ)

Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, The Netherlands.

Sisse R Ostrowski (SR)

Department of Clinical Immunology, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of health and medical sciences, University of Copenhagen, Denmark.

Aarno Palotie (A)

Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

Ole B Pedersen (OB)

Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.
Department of Clinical Medicine, Faculty of health and medical sciences, University of Copenhagen, Denmark.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Institute for Medical Information Processing, Biometry and Epidemiology - IBE, Ludwig-Maximilians-Universität München, Munich, Germany.

Giulia Pianigiani (G)

Institute for Maternal and Child Health - IRCCS ''Burlo Garofolo", Trieste, Italy.

Dijana Plaseska-Karanfilska (D)

Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov" MASA Skopje Republic of North Macedonia.

Anneli Pouta (A)

National Institute for Health and Welfare, Finland.

Alfred Pozarickij (A)

Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Paolo Radice (P)

Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research Fondazione IRCCS, Istituto Nazionale dei Tumori (INT), Milan, Italy.

Gad Rennert (G)

Clalit National Cancer Control Center, Carmel Medical Center and Technion, Faculty of Medicine, Haifa, Israel.

Frits R Rosendaal (FR)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Daniela Ruggiero (D)

Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.

Emmanouil Saloustros (E)

Department of Oncology, University Hospital of Larissa, Larissa, Greece.

Dale P Sandler (DP)

Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park, NC, USA.

Sabine Schipf (S)

Institute for Community Medicine, University Medicine Greifswald, Germany.

Carsten O Schmidt (CO)

Institute for Community Medicine, University Medicine Greifswald, Germany.

Marjanka K Schmidt (MK)

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.

Kerrin Small (K)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Beatrice Spedicati (B)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Meir Stampfer (M)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Jennifer Stone (J)

Genetic Epidemiology Group, School of Population and Global Health, University of Western Australia Perth, Western Australia, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne Melbourne, Victoria, Australia.

Rulla M Tamimi (RM)

Department of Population Health Sciences Weill Cornell Medicine New York, NY, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

Lauren R Teras (LR)

Department of Population Science American Cancer Society Atlanta, GA, USA.

Emmi Tikkanen (E)

Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

Constance Turman (C)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Celine M Vachon (CM)

Department of Quantitative Health Sciences, Division of Epidemiology Mayo Clinic Rochester, MN, USA.

Qin Wang (Q)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

Robert Winqvist (R)

Laboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Babette S Zemel (BS)

Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine Nashville, TN, USA.

Ko W van Dijk (KW)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.

Behrooz Z Alizadeh (BZ)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Stefania Bandinelli (S)

Geriatric Unit, Local Health Toscana Centro, Florence, Italy.

Eric Boerwinkle (E)

Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.

Dorret I Boomsma (DI)

Dept of Biological Psychology, Vrije Universiteit, Amsterdam; Amsterdam Public Health (APH) research institute, The Netherlands.
Amsterdam Reproduction & Development research institute, Amsterdam, The Netherlands.

Marina Ciullo (M)

Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.

Georgia Chenevix-Trench (G)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Francesco Cucca (F)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy.
University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy.

Tõnu Esko (T)

Institute of Genomics, University of Tartu, Tartu, Estonia.

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Struan Fa Grant (SF)

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Vilmundur Gudnason (V)

Icelandic Heart Association, 201 Kopavogur, Iceland.
Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.

Ivana Kolčić (I)

University of Split School of Medicine, Split, Croatia.
Algebra University College, Zagreb, Croatia.

Peter Kraft (P)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Deborah A Lawlor (DA)

MRC Integrative Epidemiology Unit at the University of Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, UK.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Ellen A Nøhr (EA)

Institute of Clinical Research, University of Southern Denmark, Department of Obstetrics & Gynecology, Odense University Hospital, Denmark.

Nancy L Pedersen (NL)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Craig E Pennell (CE)

School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales 2308, Australia.
Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia.
Department of Maternity and Gynaecology, John Hunter Hospital, Newcastle, New South Wales 2305, Australia.

Paul M Ridker (PM)

Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Antonietta Robino (A)

Institute for Maternal and Child Health - IRCCS ''Burlo Garofolo", Trieste, Italy.

Harold Snieder (H)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Ulla Sovio (U)

Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.
Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.

Tim D Spector (TD)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Doris Stöckl (D)

Gesundheitsamt Fürstenfeldbruck, Regierung von Oberbayern, Fürstenfeldbruck, Germany.

Cathie Sudlow (C)

Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.
Centre for Medical Informatics, Usher Institute, University of Edinburgh.

Nic J Timpson (NJ)

MRC Integrative Epidemiology Unit at the University of Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, UK.

Daniela Toniolo (D)

Division of Genetics and Cell Biology, San Raffele Hospital, Milano, Italy.

André Uitterlinden (A)

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Sheila Ulivi (S)

Institute for Maternal and Child Health - IRCCS ''Burlo Garofolo", Trieste, Italy.

Henry Völzke (H)

Institute for Community Medicine, University Medicine Greifswald, Germany.

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Elisabeth Widen (E)

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

James F Wilson (JF)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.

Paul Dp Pharoah (PD)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Liming Li (L)

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China.

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Pål Njølstad (P)

Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.
Department of Pediatrics and Adolescents, Haukeland University Hospital, NO-5021, Bergen, Norway.

Patrick Sulem (P)

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

Joanne M Murabito (JM)

NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
Boston University Chobanian & Avedisian School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA.

Anna Murray (A)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.

Despoina Manousaki (D)

Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada.
Department of Pediatrics, University of Montreal, Montreal, Canada.
Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, Canada.

Anders Juul (A)

Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Christian Erikstrup (C)

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Kari Stefansson (K)

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.

Momoko Horikoshi (M)

Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Zhengming Chen (Z)

Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
MRC Population Health Research Unit, University of Oxford, Oxford OX3 7LF, UK.

I Sadaf Farooqi (IS)

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Nelly Pitteloud (N)

Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, 1011 Lausanne, Switzerland.
Faculty of Biology and Medicine, University of Lausanne, Lausanne 1005, Switzerland.

Stefan Johansson (S)

Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.
Department of Medical Genetics, Haukeland University Hospital, NO-5021, Bergen, Norway.

Felix R Day (FR)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

John Rb Perry (JR)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Metabolic Research Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.

Ken K Ong (KK)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

Classifications MeSH