An open resource combining multi-contrast MRI and microscopy in the macaque brain.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 07 2023
19 07 2023
Historique:
received:
16
09
2022
accepted:
03
07
2023
medline:
21
7
2023
pubmed:
20
7
2023
entrez:
19
7
2023
Statut:
epublish
Résumé
Understanding brain structure and function often requires combining data across different modalities and scales to link microscale cellular structures to macroscale features of whole brain organisation. Here we introduce the BigMac dataset, a resource combining in vivo MRI, extensive postmortem MRI and multi-contrast microscopy for multimodal characterisation of a single whole macaque brain. The data spans modalities (MRI and microscopy), tissue states (in vivo and postmortem), and four orders of spatial magnitude, from microscopy images with micrometre or sub-micrometre resolution, to MRI signals on the order of millimetres. Crucially, the MRI and microscopy images are carefully co-registered together to facilitate quantitative multimodal analyses. Here we detail the acquisition, curation, and first release of the data, that together make BigMac a unique, openly-disseminated resource available to researchers worldwide. Further, we demonstrate example analyses and opportunities afforded by the data, including improvement of connectivity estimates from ultra-high angular resolution diffusion MRI, neuroanatomical insight provided by polarised light imaging and myelin-stained histology, and the joint analysis of MRI and microscopy data for reconstruction of the microscopy-inspired connectome. All data and code are made openly available.
Identifiants
pubmed: 37468455
doi: 10.1038/s41467-023-39916-1
pii: 10.1038/s41467-023-39916-1
pmc: PMC10356772
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4320Subventions
Organisme : Wellcome Trust
ID : WT215573/Z/19/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N019814/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : EP/L016052/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT203139/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT221933/Z/20/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT202788/Z/16/A
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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