Associations between Liver Enzymes, Lifestyle Risk Factors and Pre-Existing Medical Conditions in a Population-Based Cross-Sectional Sample.
biomarker
ethanol
hypertension
liver
obesity
physical activity
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
26 Jun 2023
26 Jun 2023
Historique:
received:
27
04
2023
revised:
20
06
2023
accepted:
24
06
2023
medline:
14
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
While alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) enzymes are commonly used indicators of liver dysfunction recent studies have suggested that these may also serve as predictive biomarkers in the assessment of extrahepatic morbidity. In order to shed further light on the interactions between serum liver enzyme abnormalities, factors of lifestyle and health status we examined ALT and GGT activities in a population-based sample of 8743 adult individuals (4048 men, 4695 women from the National FINRISK 2002 Study, mean age 48.1 ± 13.1 years) with different levels of alcohol drinking, smoking, physical activity, body weight and the presence or absence of various pre-existing medical conditions. The assessments also included laboratory tests for inflammation, lipid status and fatty liver index (FLI), a proxy for fatty liver. The prevalence of ALT and GGT abnormalities were significantly influenced by alcohol use (ALT: p < 0.0005 for men; GGT:
Identifiants
pubmed: 37445311
pii: jcm12134276
doi: 10.3390/jcm12134276
pmc: PMC10342672
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The Finnish Foundation for the Promotion of Laboratory Medicine
ID : 102014
Organisme : The Finnish Society of Clinical Chemistry
ID : 042018
Organisme : Competetive State Research Financing of the Expert Responsibility area of Seinäjoki and Tampere
ID : VTR53003116
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