Why we need families in genomic research on developmental psychopathology.
genomics
psychopathology
twin and family studies
Journal
JCPP advances
ISSN: 2692-9384
Titre abrégé: JCPP Adv
Pays: United States
ID NLM: 9918250414706676
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
09
09
2022
accepted:
21
12
2022
medline:
11
7
2023
pubmed:
11
7
2023
entrez:
11
7
2023
Statut:
epublish
Résumé
Fundamental questions about the roles of genes, environments, and their interplay in developmental psychopathology have traditionally been the domain of twin and family studies. More recently, the rapidly growing availability of large genomic datasets, composed of unrelated individuals, has generated novel insights. However, there are major stumbling blocks. Only a small fraction of the total genetic influence on childhood psychopathology estimated from family data is captured with measured DNA. Moreover, genetic influence identified using DNA is often confounded with indirect genetic effects of relatives, population stratification and assortative mating. The goal of this paper is to review how combining DNA-based genomic research with family-based quantitative genetics helps to address key issues in genomics and push knowledge further. We focus on three approaches to obtaining more accurate and novel genomic findings on the developmental aetiology of psychopathology: (a) using knowledge from twin and family studies, (b) triangulating with twin and family studies, and (c) integrating data and methods with twin and family studies. We support the movement towards family-based genomic research, and show that developmental psychologists are particularly well-placed to contribute hypotheses, analysis tools, and data.
Sections du résumé
Background
UNASSIGNED
Fundamental questions about the roles of genes, environments, and their interplay in developmental psychopathology have traditionally been the domain of twin and family studies. More recently, the rapidly growing availability of large genomic datasets, composed of unrelated individuals, has generated novel insights. However, there are major stumbling blocks. Only a small fraction of the total genetic influence on childhood psychopathology estimated from family data is captured with measured DNA. Moreover, genetic influence identified using DNA is often confounded with indirect genetic effects of relatives, population stratification and assortative mating.
Methods
UNASSIGNED
The goal of this paper is to review how combining DNA-based genomic research with family-based quantitative genetics helps to address key issues in genomics and push knowledge further.
Results
UNASSIGNED
We focus on three approaches to obtaining more accurate and novel genomic findings on the developmental aetiology of psychopathology: (a) using knowledge from twin and family studies, (b) triangulating with twin and family studies, and (c) integrating data and methods with twin and family studies.
Conclusion
UNASSIGNED
We support the movement towards family-based genomic research, and show that developmental psychologists are particularly well-placed to contribute hypotheses, analysis tools, and data.
Identifiants
pubmed: 37431320
doi: 10.1002/jcv2.12138
pii: JCV212138
pmc: PMC10241449
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12138Informations de copyright
© 2023 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.
Déclaration de conflit d'intérêts
Eivind Ystrom is a Joint Editor for JCPP Advances. The remaining authors have declared that they have no competing or potential conflicts of interest.
Références
Am J Med Genet B Neuropsychiatr Genet. 2020 Jul;183(5):258-267
pubmed: 32356930
Heredity (Edinb). 1978 Dec;41(3):249-320
pubmed: 370072
Psychol Sci. 2020 May;31(5):582-591
pubmed: 32302253
J Am Acad Child Adolesc Psychiatry. 2022 Jul;61(7):934-945
pubmed: 35378236
Transl Psychiatry. 2018 Oct 17;8(1):223
pubmed: 30333497
Mol Psychiatry. 2018 Dec;23(12):2347-2362
pubmed: 29321673
Nat Rev Genet. 2018 Sep;19(9):566-580
pubmed: 29872216
Nat Genet. 2022 May;54(5):581-592
pubmed: 35534559
J Child Psychol Psychiatry. 2022 Oct;63(10):1174-1185
pubmed: 35789088
Behav Genet. 2020 Mar;50(2):84-93
pubmed: 31802328
Eur Arch Psychiatry Clin Neurosci. 2009 Aug;259(5):270-7
pubmed: 19224110
J Child Psychol Psychiatry. 2019 Dec;60(12):1269-1277
pubmed: 31106427
Nature. 2009 Oct 8;461(7265):747-53
pubmed: 19812666
Nat Commun. 2022 Aug 23;13(1):4801
pubmed: 35999215
BMC Med. 2020 Oct 27;18(1):284
pubmed: 33106172
Twin Res Hum Genet. 2005 Jun;8(3):214-23
pubmed: 15989749
Int J Epidemiol. 2023 Apr 19;52(2):624-632
pubmed: 36427280
PLoS Genet. 2016 Feb 11;12(2):e1005765
pubmed: 26866486
Science. 2018 Jan 26;359(6374):424-428
pubmed: 29371463
J Child Psychol Psychiatry. 2022 Oct;63(10):1153-1163
pubmed: 35833717
Behav Genet. 2014 Sep;44(5):445-55
pubmed: 25060210
J Child Psychol Psychiatry. 2022 Oct;63(10):1186-1195
pubmed: 35778910
Nat Genet. 2018 Sep;50(9):1304-1310
pubmed: 30104764
Science. 2019 Sep 27;365(6460):1396-1400
pubmed: 31604265
Cold Spring Harb Perspect Med. 2021 Aug 2;11(8):
pubmed: 33355252
Trends Cogn Sci. 2021 Oct;25(10):855-869
pubmed: 34312064
PLoS One. 2022 Aug 22;17(8):e0273116
pubmed: 35994476
Dev Sci. 2012 Mar;15(2):250-9
pubmed: 22356180
Clin Genet. 1984 Jan;25(1):15-24
pubmed: 6538464
Nat Genet. 2022 Apr;54(4):437-449
pubmed: 35361970
Genome Biol. 2022 Jun 20;23(1):131
pubmed: 35725481
NPJ Sci Learn. 2020 Feb 5;5:1
pubmed: 32047651
Nat Genet. 2017 Aug 30;49(9):1304-1310
pubmed: 28854176
J Child Psychol Psychiatry. 2022 Oct;63(10):1214-1218
pubmed: 36005740
Nat Genet. 2022 Mar;54(3):263-273
pubmed: 35256806
Transl Psychiatry. 2017 Dec 12;7(12):1284
pubmed: 29234009
J Child Psychol Psychiatry. 2023 Apr;64(4):693-707
pubmed: 36379220
JAMA Psychiatry. 2014 Aug;71(8):905-16
pubmed: 24920372
Genetics. 2019 Apr;211(4):1125-1130
pubmed: 30967441
Behav Genet. 2010 May;40(3):377-93
pubmed: 20013306
Nature. 2008 Nov 6;456(7218):18-21
pubmed: 18987709
J Child Psychol Psychiatry. 2010 Jul;51(7):772-9
pubmed: 20202040
Behav Genet. 2021 Mar;51(2):154-161
pubmed: 33387132
Nat Neurosci. 2021 Oct;24(10):1367-1376
pubmed: 34446935
Sci Adv. 2020 Apr 15;6(16):eaay0328
pubmed: 32426451
Psychol Monogr. 1966;80(7):1-37
pubmed: 5968338
Perspect Psychol Sci. 2016 Jan;11(1):3-23
pubmed: 26817721
PLoS Genet. 2006 Mar;2(3):e41
pubmed: 16565746
JAMA Psychiatry. 2013 Oct;70(10):1076-83
pubmed: 23965950
Dev Psychopathol. 2016 Feb;28(1):149-66
pubmed: 25924807
Psychol Med. 2016 Jan;46(1):161-75
pubmed: 26310536