Executive functions and borderline personality features in adolescents with major depressive disorder.

adolescents borderline personality disorder emotion regulation executive function inhibition major depressive disorder

Journal

Frontiers in human neuroscience

ISSN: 1662-5161

Titre abrégé: Front Hum Neurosci

Pays: Switzerland

ID NLM: 101477954

Informations de publication

Date de publication:
2023

Historique:

received: 31 05 2022

accepted: 26 05 2023

medline: 10 7 2023

pubmed: 10 7 2023

entrez: 10 7 2023

Statut: epublish

Résumé

Executive functions (EF) consolidate during adolescence and are impaired in various emerging psychiatric disorders, such as pediatric Major Depressive Disorder (pMDD) and Borderline Personality Disorder. Previous studies point to a marked heterogeneity of deficits in EF in pMDD. We examined the hypothesis that deficits in EF in adolescents with pMDD might be related to comorbid Borderline Personality features (BPF). We examined a sample of 144 adolescents (15.86 ± 1.32) diagnosed with pMDD. Parents rated their child's EF in everyday life with the Behavior Rating Inventory of Executive Function (BRIEF) and BPF with the Impulsivity and Emotion Dysregulation Scale (IED-27). The adolescents completed equivalent self-rating measures. Self- and parent-ratings of the BRIEF scores were compared with paired t-Tests. Correlation and parallel mediation analyses, ICC, and multiple regression analyses were used to assess symptom overlap, parent-child agreement, and the influence of depression severity. Over the whole sample, none of the self- or parent-rated BRIEF scales reached a mean score above T > 65, which would indicate clinically impaired functioning. Adolescents tended to report higher impairment in EF than their parents. Depression severity was the strongest predictor for BPF scores, with On average, adolescents with depression show only subtle deficits in executive functioning. However, increased EF deficits are associated with the occurrence of comorbid borderline personality features, contributing to a more severe overall psychopathology. Therefore, training of executive functioning might have a positive effect on psychosocial functioning in severely depressed adolescents, as it might also improve comorbid BPF. www.ClinicalTrials.gov, identifier NCT03167307.

Sections du résumé

Background UNASSIGNED

Methods UNASSIGNED

We examined a sample of 144 adolescents (15.86 ± 1.32) diagnosed with pMDD. Parents rated their child's EF in everyday life with the Behavior Rating Inventory of Executive Function (BRIEF) and BPF with the Impulsivity and Emotion Dysregulation Scale (IED-27). The adolescents completed equivalent self-rating measures. Self- and parent-ratings of the BRIEF scores were compared with paired t-Tests. Correlation and parallel mediation analyses, ICC, and multiple regression analyses were used to assess symptom overlap, parent-child agreement, and the influence of depression severity.

Results UNASSIGNED

Over the whole sample, none of the self- or parent-rated BRIEF scales reached a mean score above T > 65, which would indicate clinically impaired functioning. Adolescents tended to report higher impairment in EF than their parents. Depression severity was the strongest predictor for BPF scores, with

Conclusion UNASSIGNED

On average, adolescents with depression show only subtle deficits in executive functioning. However, increased EF deficits are associated with the occurrence of comorbid borderline personality features, contributing to a more severe overall psychopathology. Therefore, training of executive functioning might have a positive effect on psychosocial functioning in severely depressed adolescents, as it might also improve comorbid BPF.

Clinical trial registration UNASSIGNED

www.ClinicalTrials.gov, identifier NCT03167307.

Identifiants

DOI: 10.3389/fnhum.2023.957753 PMID: 37425294 PMC: PMC10325791

pubmed: 37425294

doi: 10.3389/fnhum.2023.957753

pmc: PMC10325791

doi:

Banques de données

ClinicalTrials.gov

['NCT03167307']

Types de publication

Journal Article

Langues

eng

Pagination

957753

Investigateurs

Noemi Baumgartner (N)

Sophie Emery (S)

Mona Albermann (M)

Kristin Nalani (K)

Oliver Pick (O)

Alain Di Gallo (A)

Michael Strumberger (M)

Brigitte Contin (B)

Stefan Müller (S)

Silke Bachmann (S)

Lars Wöckel (L)

Simone Heitzer (S)

Bruno Rhiner (B)

Amir Yamini (A)

Suzanne Erb (S)

Michael Schmid (M)

Ulrich Müller-Knapp (U)

Ioannis Christodoulakis (I)

Ulrike Held (U)

Burkhardt Seifert (B)

Edna Grünblatt (E)

Martin Hersberger (M)

Ivan Hartling (I)

Romuald Brunner (R)

Jürgen Drewe (J)

Julia Braun (J)

Jenny Peterson (J)

Informations de copyright

Déclaration de conflit d'intérêts

KS has received royalties from Springer, Hogrefe, Schattauer, and Vandenhoeck & Ruprecht. His work was supported by the Swiss National Science Foundation (SNF), the Swiss Ministry of Justice, the Botnar Foundation, Stiftung zur Förderung von Psychiatrie und Psychotherapie, and Gertrud Thalmann Fonds. GB was supported by the Swiss National Science Foundation, Gesundheitsförderung Schweiz, the Stanley Foundation, the Gertrud Thalmann Fonds, and the Ebnet Foundation and he has received lecture honoraria from Lundbeck, Opopharma, Antistress AG (Burgerstein) in the last five years. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

J Atten Disord. 2007 May;10(4):381-9

pubmed: 17449837

Disabil Rehabil. 2015;37(22):2092-106

pubmed: 25673145

Psychiatry Res Neuroimaging. 2017 Feb 28;260:76-85

pubmed: 28039797

Brain Sci. 2021 Sep 27;11(10):

pubmed: 34679345

Psychiatry Res. 2008 Jul 15;163(2):116-25

pubmed: 18395424

Clin Psychol Rev. 2008 Jul;28(6):969-81

pubmed: 18358579

J Pediatr Nurs. 2019 Jul - Aug;47:23-29

pubmed: 31022629

BMC Psychol. 2023 Feb 2;11(1):33

pubmed: 36732818

Dev Psychopathol. 2019 Aug;31(3):1143-1156

pubmed: 31169118

Appl Neuropsychol Child. 2019 Jul-Sep;8(3):264-271

pubmed: 29509035

J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8

pubmed: 9204677

Front Psychol. 2019 Mar 20;10:543

pubmed: 30949092

J Affect Disord. 2020 Jul 1;272:223-230

pubmed: 32553362

Eur Neuropsychopharmacol. 2019 Jan;29(1):46-56

pubmed: 30503099

Psychol Assess. 2012 Jun;24(2):293-300

pubmed: 21928910

J Abnorm Child Psychol. 2018 Jul;46(5):1077-1088

pubmed: 29124497

Psychol Med. 2011 Mar;41(3):601-10

pubmed: 20482935

Psychiatry Res. 2020 Jun;288:113023

pubmed: 32360894

Eur Child Adolesc Psychiatry. 2015 Jan;24(1):5-19

pubmed: 24869711

Eur Neuropsychopharmacol. 2015 Feb;25(2):203-13

pubmed: 25190638

Qual Life Res. 2008 Aug;17(6):895-913

pubmed: 18521721

Psychol Bull. 2015 Jul;141(4):858-900

pubmed: 25915035

Science. 2011 Aug 19;333(6045):959-64

pubmed: 21852486

Acta Psychiatr Scand. 2008 Nov;118(5):410-3

pubmed: 18644003

J Youth Adolesc. 2020 Jan;49(1):311-322

pubmed: 31446584

Nord J Psychiatry. 2004;58(1):41-7

pubmed: 14985153

Clin Psychol Rev. 2010 Jul;30(5):562-81

pubmed: 20457481

J Chiropr Med. 2016 Jun;15(2):155-63

pubmed: 27330520

J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):37-44.e2

pubmed: 25524788

Arch Suicide Res. 2021 Jul-Sep;25(3):657-671

pubmed: 32264769

J Clin Child Adolesc Psychol. 2016;45(1):44-58

pubmed: 26042358

Child Neuropsychol. 2002 Dec;8(4):249-57

pubmed: 12759822

J Am Acad Child Adolesc Psychiatry. 2012 Dec;51(12):1314-1323.e2

pubmed: 23200288

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9

pubmed: 15148381

Child Neuropsychol. 2018 Aug;24(6):844-858

pubmed: 28693404

Cogn Psychol. 2000 Aug;41(1):49-100

pubmed: 10945922

Lancet. 2004 Jul 31-Aug 6;364(9432):453-61

pubmed: 15288745

Dev Neuropsychol. 2019 Jan-Feb;44(1):88-103

pubmed: 30395731

Dev Psychopathol. 2019 Feb;31(1):379-392

pubmed: 29506584

Pediatrics. 2019 Feb;143(2):

pubmed: 30642950

Psychother Psychosom Med Psychol. 2021 May;71(5):177-184

pubmed: 33440448

Psychol Assess. 2018 May;30(5):669-677

pubmed: 28782976

Personal Ment Health. 2016 Feb;10(1):43-57

pubmed: 26381859

J Child Psychol Psychiatry. 2015 Mar;56(3):345-65

pubmed: 25649325

Psychiatry Res. 2018 Oct;268:419-425

pubmed: 30130708

J Psychosom Res. 2020 Aug 17;137:110222

pubmed: 32841758

Acta Psychiatr Scand. 2012 Apr;125(4):281-92

pubmed: 22007857

Psychiatry Res. 2014 Aug 30;218(3):261-71

pubmed: 24851725

Dev Psychopathol. 2013 Nov;25(4 Pt 2):1325-45

pubmed: 24342843

Eur Child Adolesc Psychiatry. 2015 Apr;24(4):365-84

pubmed: 25633323

J Child Psychol Psychiatry. 2018 Jun;59(6):628-636

pubmed: 29063592

Dtsch Arztebl Int. 2013 Jun;110(25):425-31

pubmed: 23840287

Neurosci Biobehav Rev. 2022 Jan;132:92-109

pubmed: 34774586

Front Neurosci. 2016 Aug 23;10:386

pubmed: 27601977

Lancet. 2021 Oct 23;398(10310):1528-1540

pubmed: 34688371

Clin Neurophysiol. 2005 Jun;116(6):1424-32

pubmed: 15978505

J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):394-403

pubmed: 22449645

Child Neuropsychol. 2017 Nov;23(8):935-953

pubmed: 27535347

Australas Psychiatry. 2019 Dec;27(6):573-577

pubmed: 31573324

Front Psychiatry. 2019 Nov 27;10:863

pubmed: 31827448

Curr Psychiatry Rep. 2017 Mar;19(3):17

pubmed: 28290062

Z Kinder Jugendpsychiatr Psychother. 2011 May;39(3):179-85

pubmed: 21563109

Front Psychiatry. 2022 Aug 16;13:980392

pubmed: 36051550

Pediatrics. 2014 Oct;134(4):782-93

pubmed: 25246626

Nord J Psychiatry. 2022 Aug;76(6):466-473

pubmed: 34792428

Child Neuropsychol. 2019 Jul;25(5):599-616

pubmed: 30111231

J Abnorm Child Psychol. 1983 Jun;11(2):167-79

pubmed: 6619431

Personal Ment Health. 2018 May;12(2):93-106

pubmed: 29388349

Med J Aust. 2013 Sep 16;199(6 Suppl):S24-7

pubmed: 25370280

J Affect Disord. 2018 May;232:96-102

pubmed: 29481997

J Pers Disord. 2021 Jun;35(Suppl B):94-110

pubmed: 33999657

Dev Rev. 2008;28(1):62-77

pubmed: 18688292

Psychol Med. 2023 Jul;53(9):4228-4235

pubmed: 35466895

Psychiatry Res. 2013 Nov 30;210(1):224-31

pubmed: 23764434

Soc Psychiatry Psychiatr Epidemiol. 2021 Nov;56(11):2053-2062

pubmed: 33745001

J Affect Disord. 2022 Dec 15;319:181-188

pubmed: 36155238

Child Neuropsychol. 2000 Sep;6(3):235-8

pubmed: 11419452

Psychiatry Res. 2018 Apr;262:333-339

pubmed: 28363497

Annu Rev Psychol. 2014;65:187-207

pubmed: 24016274

J Clin Child Adolesc Psychol. 2016;45(1):84-9

pubmed: 26743038

Innov Clin Neurosci. 2011 May;8(5):16-20

pubmed: 21686143

J Atten Disord. 2018 Jun;22(8):764-775

pubmed: 25922184

Clin Psychol Sci. 2018 Jul;6(4):543-560

pubmed: 30250762

J Atten Disord. 2019 Sep;23(11):1368-1378

pubmed: 28799448

Child Adolesc Ment Health. 2019 Nov;24(4):338-344

pubmed: 32677348

Dev Cogn Neurosci. 2021 Oct;51:100994

pubmed: 34332330

Z Kinder Jugendpsychiatr Psychother. 2020 Nov;48(6):1-5

pubmed: 31755846

Front Psychiatry. 2021 May 31;12:667238

pubmed: 34135786

Biol Psychiatry. 2003 Dec 1;54(11):1284-93

pubmed: 14643096

R Soc Open Sci. 2015 Nov 25;2(11):150117

pubmed: 26715991