Advanced Procedure of Simultaneous Electrodeposition from a Natural Deep Eutectic Solvent of a Drug and a Polymer Used to Improve TiZr Alloy Behavior.
NADES
TiZr alloy
antibacterial activity
drug release
electrochemical stability
gentamicin
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
14 Jun 2023
14 Jun 2023
Historique:
received:
23
05
2023
revised:
12
06
2023
accepted:
13
06
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
This paper presents research about the embedding and release of gentamicin from an electrochemical deposition of polypyrrole from ionic liquids such as choline chloride on TiZr bioalloy. The electrodeposited films were morphologically investigated using scanning electron microscopy (SEM) with an EDX module, and polypyrrole and gentamicin were both identified using structural FT-IR analysis. The film's characterization was completed with an evaluation of hydrophilic-hydrophobic balance, with electrochemical stability measurements in PBS and with antibacterial inhibition. A decrease in the value of the contact angle was observed from 47.06° in the case of the uncoated sample to 8.63° in the case of the sample covered with PPy and GS. Additionally, an improvement in the anticorrosive properties of the coating was observed by increasing the efficiency to 87.23% in the case of TiZr-PPy-GS. A kinetic study of drug release was performed as well. The drug molecule might be provided by the PPy-GS coatings for up to 144 h. The highest amount released was calculated to be 90% of the entire drug reservoir capacity, demonstrating the effectiveness of the coatings. A non-Fickian behavior was established as a mechanism for the release profiles of the gentamicin from the polymer layer.
Identifiants
pubmed: 37374570
pii: ma16124387
doi: 10.3390/ma16124387
pmc: PMC10302225
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Jpn Dent Sci Rev. 2023 Dec;59:28-37
pubmed: 36819742
Eur J Pharm Sci. 2001 May;13(2):123-33
pubmed: 11297896
J Biomater Appl. 2019 Jan;33(6):766-775
pubmed: 30396325
Int J Pharm. 2015 Aug 15;492(1-2):73-9
pubmed: 26142248
Acta Biomater. 2015 Sep;24:370-7
pubmed: 26092351
Regen Biomater. 2017 Oct;4(5):315-323
pubmed: 29026646
Bioelectrochemistry. 2010 Aug;79(1):11-6
pubmed: 19879816
Biotechnol Adv. 2015 Nov 1;33(6 Pt 3):1310-26
pubmed: 25900197
Int J Mol Sci. 2022 Mar 27;23(7):
pubmed: 35409025
J Funct Biomater. 2022 Oct 01;13(4):
pubmed: 36278642
Nanomaterials (Basel). 2021 May 17;11(5):
pubmed: 34067723
Sci Rep. 2020 Feb 14;10(1):2621
pubmed: 32060364
Clin Microbiol Infect. 2010 Dec;16(12):1729-35
pubmed: 20673257
Biomed Mater Eng. 2019;30(1):85-95
pubmed: 30562891
Pharmaceutics. 2018 Nov 08;10(4):
pubmed: 30413075
Mater Sci Eng C Mater Biol Appl. 2021 Apr;123:112021
pubmed: 33812638
Molecules. 2020 Apr 30;25(9):
pubmed: 32365745
Arthroplast Today. 2022 Mar 15;14:133-139
pubmed: 35308048
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109743
pubmed: 31349530
J Chem Phys. 2007 Nov 14;127(18):184310
pubmed: 18020642
Dent Mater J. 2022 Apr 1;41(2):266-272
pubmed: 34866118
Materials (Basel). 2020 Feb 25;13(5):
pubmed: 32106401
Int J Mol Sci. 2017 Dec 22;19(1):
pubmed: 29271916
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109757
pubmed: 31499987
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:856-64
pubmed: 27612780
Colloids Surf B Biointerfaces. 2020 Jan 1;185:110535
pubmed: 31629971
Expert Opin Drug Deliv. 2019 May;16(5):497-506
pubmed: 30955386
Pharmaceutics. 2023 Jan 09;15(1):
pubmed: 36678852