Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis.
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
01
06
2023
received:
06
09
2022
accepted:
22
06
2023
pmc-release:
01
12
2024
medline:
30
11
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
Women with rheumatoid arthritis (RA) have higher pain and worse functional outcomes compared to men, even when treated with similar medications. The objective of this study was to identify sex differences in pain intensity, pain interference, and quantitative sensory tests (QST), which are independent of inflammation, in patients with RA. This study is a post hoc analysis of participants in the Central Pain in Rheumatoid Arthritis cohort. Pain intensity was assessed using a 0-10 numeric rating scale. Pain interference was measured using a Patient-Reported Outcomes Measurement Information System computerized adaptive test. QST included pressure pain detection thresholds, temporal summation, and conditioned pain modulation. Women and men were compared using multiple linear regression, adjusted for age, education, race, research site, depression, obesity, RA disease duration, swollen joint count, and C-reactive protein. Mean ± SD pain intensity was 5.32 ± 2.29 among women with RA, compared to 4.60 ± 2.23 among men with RA (adjusted difference 0.83 [95% confidence interval (95% CI) 0.14, 1.53]). Women with RA had lower pressure pain detection thresholds at the trapezius (adjusted difference -1.22 [95% CI -1.73, -0.72]), wrist (adjusted difference -0.57 [95% CI -1.07, -0.06]), and knee (adjusted difference -1.10 [95% CI -2.00, -0.21]). No statistically significant differences in pain interference, temporal summation, and conditioned pain modulation were observed. Women reported higher pain intensity and lower pressure pain detection thresholds (higher pain sensitivity) than men. However, pain interference, temporal summation, and conditioned pain modulation did not differ between men and women.
Identifiants
pubmed: 37365745
doi: 10.1002/acr.25178
pmc: PMC10704379
mid: NIHMS1921494
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2472-2480Subventions
Organisme : NIAMS NIH HHS
ID : K24 AR080840
Pays : United States
Organisme : NIAMS NIH HHS
ID : K24-AR-080840
Pays : United States
Organisme : NIAMS NIH HHS
ID : K24 AR070892
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30-AR-070254
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01-AR-064850
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR064850
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR070254
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072571
Pays : United States
Organisme : NIAMS NIH HHS
ID : K24-AR-070892
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30-AR-072571
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072579
Pays : United States
Informations de copyright
© 2023 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
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