X-Ray Conformation and Structure-Activity Relationships of MA026, a Reversible Tight Junction Opener.

Tight Junctions / metabolism X-Rays Claudin-1 / metabolism Amino Acid Sequence Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 07 2023
Historique:
medline: 14 7 2023
pubmed: 23 6 2023
entrez: 23 6 2023
Statut: ppublish

Résumé

MA026, a cyclic lipodepsipeptide, opens the tight junction (TJ) probably via binding to claudin-1. We reported that (1) TJ-opening activity is dependent on the amino acid sequence order at Glu10-Leu11; (2) an epimer at the C3 position of the

Identifiants

DOI: 10.1021/acs.jmedchem.3c00365 PMID: 37352439
pubmed: 37352439
doi: 10.1021/acs.jmedchem.3c00365
doi:

Substances chimiques

Claudin-1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8717-8724

Auteurs

Minagi Mukaiyama (M)

Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.

Chihiro Uchiyama (C)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Akane Fukuda (A)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Yoshiki Nakazawa (Y)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Yuka Kuramochi (Y)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Yudai Shibata (Y)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Sho Konno (S)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Kyohei Muguruma (K)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Naohiro Matsugaki (N)

Structural Biology Research Center, High Energy Accelerator Research Organization (KEK), Institute of Materials Structure Science, Tsukuba, Ibaraki 305-0801, Japan.
Department of Materials Structure Science, School of High Energy Accelerator Science, The Graduate University of Advanced Studies (Soken-dai), 1-1 Oho, Tsukuba, Tsukuba, Ibaraki 305-0801, Japan.

Tomo Asari (T)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Kazuyoshi Ogawa (K)

Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
ORCID: 0000-0003-1762-9799

Akihiro Taguchi (A)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Kentaro Takayama (K)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Atsuhiko Taniguchi (A)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Yoko Nagumo (Y)

Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Institute of Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.

Toshiya Senda (T)

Institute of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Structural Biology Research Center, High Energy Accelerator Research Organization (KEK), Institute of Materials Structure Science, Tsukuba, Ibaraki 305-0801, Japan.
Department of Materials Structure Science, School of High Energy Accelerator Science, The Graduate University of Advanced Studies (Soken-dai), 1-1 Oho, Tsukuba, Tsukuba, Ibaraki 305-0801, Japan.

Yoshio Hayashi (Y)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
ORCID: 0000-0002-7010-6914

Takeo Usui (T)

Institute of Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
ORCID: 0000-0003-2377-7499

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Classifications MeSH

Recherchemedicale.com › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions serrées › X-Ray Conformation and Structure-Activity...
Recherchemedicale.com › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons X › X-Ray Conformation and Structure-Activity...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de la jonction serrée › Claudines › Claudine-1 › X-Ray Conformation and Structure-Activity...
Recherchemedicale.com › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › X-Ray Conformation and Structure-Activity...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › X-Ray Conformation and Structure-Activity...