Evaluation of the mandibular condylar bone microarchitecture in people living with HIV.
HIV
cone beam computed tomography
cortical bone
mandibular condyle
quantitative microstructure evaluation
temporomandibular disorders
trabecular bone
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
20 Jun 2023
20 Jun 2023
Historique:
revised:
24
05
2023
received:
10
02
2023
accepted:
06
06
2023
medline:
20
6
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
aheadofprint
Résumé
People living with HIV (PLWH) have been shown to have lower bone density at the spine, hip, and radius. However, whether a similar bone phenotype is seen in craniofacial bones is not known. The goal of this study was to evaluate the bone microarchitecture of the mandibular condyle in PLWH. We recruited 212 participants, which included 88 HIV-negative participants and 124 PLWH on combination antiretroviral therapy with virological suppression from a single academic center. Each participant filled out a validated temporomandibular disorder (TMD) pain screening questionnaire and had cone beam computed tomography (CBCT) of their mandibular condyles. Qualitative radiographic evidence of temporomandibular joint disorders-osteoarthritis (TMJD-OA) assessment and quantitative microarchitecture analysis of their mandibular condylar bones were conducted. There was no statistically significant difference in either self-reported TMD or in radiographic evidence of TMJD-OA in PLWH compared with HIV-negative controls. Linear regression analysis revealed that positive HIV status remained significantly associated with increased trabecular thickness, decreased cortical porosity, and increased cortical bone volume fraction after adjusting for race, diabetes, sex, and age. PLWH have increased mandibular condylar trabecular bone thickness and cortical bone volume fraction compared with HIV-negative controls.
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026924
Pays : United States
Organisme : NIH HHS
ID : R01-DE026924
Pays : United States
Informations de copyright
© 2023 Wiley Periodicals LLC.
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