Inflammatory-like status and acute stress response in horses after road transport.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 06 2023
17 06 2023
Historique:
received:
03
04
2023
accepted:
15
06
2023
medline:
19
6
2023
pubmed:
18
6
2023
entrez:
17
6
2023
Statut:
epublish
Résumé
This study aimed to evaluate the change of white blood cell count, serum concentration of cortisol, C-reactive protein, albumin and globulin fractions in horse after road transport, and to assess the linkage among hypothalamic-pituitary-adrenal axis (HPA) and inflammatory reaction. From 10 horses blood samples were collected at rest, before road transport (218 km) (BT); after unloaded (AT), 30 and 60 min after unloaded (AT30 and AT60) in order to assess white blood cell count (WBC), serum cortisol, C-reactive protein (CRP), total proteins, albumin, α1-, α-2, β1-, β2- and γ-globulins. WBC, cortisol, CRP, α1-, α-2 and β2-globulins values increased after road transport than rest condition (p < 0.001). Albumin and A/G ratio showed lower values after road transport than rest (p < 0.001). Pearson's test showed a negative correlation between cortisol and the values of WBC, CRP, α1-, α2-, β1-, β2- globulins, and a positive correlation between WBC and serum concentration of CRP, α1- and α2-, β1-, β2-globulins at AT and AT30. The results showed that road transport evokes an inflammatory like-status in horses. Moreover, the activation of HPA and the onset of acute phase reaction in response to road transport seem to be interconnected with effects on horse's immune status.
Identifiants
pubmed: 37330619
doi: 10.1038/s41598-023-37069-1
pii: 10.1038/s41598-023-37069-1
pmc: PMC10276830
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
C-Reactive Protein
9007-41-4
Globulins
0
Albumins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9858Informations de copyright
© 2023. The Author(s).
Références
Exp Anim. 2015;64(1):19-24
pubmed: 25100022
J Pharm Bioallied Sci. 2011 Jan;3(1):118-27
pubmed: 21430962
J Anim Sci. 2013 Oct;91(10):4925-35
pubmed: 23989882
Comp Med. 2009 Dec;59(6):517-26
pubmed: 20034426
PLoS One. 2021 Aug 19;16(8):e0254139
pubmed: 34411137
Animals (Basel). 2020 Dec 14;10(12):
pubmed: 33327382
Equine Vet J Suppl. 2006 Aug;(36):274-8
pubmed: 17402431
J Neuroimmunol. 2005 Feb;159(1-2):119-28
pubmed: 15652410
J Anim Sci. 2008 Jun;86(6):1325-34
pubmed: 18344301
Brain Behav Immun. 2015 Jan;43:139-48
pubmed: 25107875
Res Vet Sci. 2012 Oct;93(2):914-7
pubmed: 22296939
J Vet Med Sci. 2011 Nov;73(11):1531-4
pubmed: 21757859
J Equine Vet Sci. 2022 Oct;117:104061
pubmed: 35793771
Cell Mol Immunol. 2016 May;13(3):267-76
pubmed: 27063467
J Vet Intern Med. 2018 Sep;32(5):1726-1730
pubmed: 30216559
J Neuroimmunol. 2005 Sep;166(1-2):144-57
pubmed: 16026859
Vet J. 2007 May;173(3):669-74
pubmed: 16584904
Res Vet Sci. 2017 Dec;115:78-87
pubmed: 28160731
Immunopharmacology. 1988 Nov-Dec;16(3):125-37
pubmed: 2855326
Animals (Basel). 2020 May 29;10(6):
pubmed: 32486015
Rev Sci Tech. 2005 Aug;24(2):683-91
pubmed: 16358519
Annu Rev Immunol. 2000;18:309-45
pubmed: 10837061
J Neuroimmunol. 1995 Mar;57(1-2):27-34
pubmed: 7706438