L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice.
Antioxidant
L-theanine
Mice
Multiple sclerosis
Journal
Archives of Razi Institute
ISSN: 2008-9872
Titre abrégé: Arch Razi Inst
Pays: Iran
ID NLM: 101549567
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
06
09
2022
accepted:
01
10
2022
medline:
15
6
2023
pubmed:
14
6
2023
entrez:
14
6
2023
Statut:
epublish
Résumé
This study designed to investigate the protective effects of L-theanine on experimental Multiple sclerosis in mice. Frothy Male C57BL/6 mice were allocated into 4 experimental groups: control no treatment received a regular chew pellet, and the cuprizone (CPZ) group received a standard chew pellet containing 0.2% (w/w) CPZ. In group 3, mice were fed a regular diet and administered p.o. with L-theanine (50mg/kg). In group 4, mice received a diet containing CPZ and were administered p.o. with L-theanine (50mg/kg). Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on findings, CPZ significantly decreased ambulation score, hind-limb suspension, front limb suspension, and grip strength (
Identifiants
pubmed: 37312698
doi: 10.22092/ARI.2022.360066.2544
pii: ARI-78-1
pmc: PMC10258260
doi:
Substances chimiques
theanine
8021PR16QO
Antioxidants
0
Cuprizone
5N16U7E0AO
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-203Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
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