The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis.

Humans Female Pregnancy Vitamin D Pregnant Women COVID-19 Vitamins Vitamin D Deficiency
COVID-19 SARS-CoV-2 pregnancy vitamin D

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
31 May 2023
Historique:
received: 04 05 2023
revised: 27 05 2023
accepted: 30 05 2023
medline: 12 6 2023
pubmed: 10 6 2023
entrez: 10 6 2023
Statut: epublish

Résumé

Vitamin D can modulate immune responses, and its deficiency is linked to increased autoimmunity and susceptibility to infection. In the general population, it has been observed that serum vitamin D levels are connected with the risk of COVID-19 and its severity. Our study aims to examine reported findings on the effect of vitamin D serum levels on infection of COVID-19 during pregnancy. PubMed, Web of Science, Embase, and Cochrane Library were searched for relevant studies. Serum vitamin D serum levels in COVID-19-positive and COVID-19-negative pregnant women were 24.61 ± 20.86 ng/mL and 24.12 ± 17.33 ng/mL, respectively. In mild vs. moderate to critical COVID-19 pregnant women, vitamin D serum levels were 16.71 ± 9.04 ng/mL vs. 10.7 ± 9.37 ng/mL and severe vs. non-severe were 13.21 ± 11.47 ng/mL vs. 15.76 ± 10.0 ng/mL. Only one study reported vitamin D serum levels in the placenta of COVID-19-positive pregnant women compared with the control and results varied and amounted to 14.06 ± 0.51 ng/mL vs. 12.45 ± 0.58 ng/mL, respectively. Vitamin D deficiency tends to be common in pregnant women who have COVID-19, and the level of this vitamin has been demonstrated to have a strong correlation with the severity of the illness. As vitamin D serum levels correlate with COVID-19 symptoms and even with its occurrence, appropriate vitamin D supplementation in the prenatal period is suggested.

Identifiants

DOI: 10.3390/nu15112588 PMID: 37299555 PMC: PMC10255765
pubmed: 37299555
pii: nu15112588
doi: 10.3390/nu15112588
pmc: PMC10255765
pii:
doi:

Substances chimiques

Vitamin D 1406-16-2
Vitamins 0

Types de publication

Meta-Analysis Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Luiza Szarpak (L)

Research Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, Poland.

Stepan Feduniw (S)

Department of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.
Department of Gynecology, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.
ORCID: 0000-0001-7746-8443

Michal Pruc (M)

Research Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, Poland.
Research Unit, International Academy of Ecology and Medicine, 02091 Kyiv, Ukraine.
ORCID: 0000-0002-2140-9732

Michal Ciebiera (M)

Second Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 00-189 Warsaw, Poland.
ORCID: 0000-0001-5780-5983

Basar Cander (B)

Department of Emergency Medicine, Bezmialem Vakif University, Fatih, 34093 Istanbul, Turkey.

Mansur Rahnama-Hezavah (M)

Chair and Department of Oral Surgery, Medical University of Lublin, 20-093 Lublin, Poland.

Łukasz Szarpak (Ł)

Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Research Unit, Maria Sklodowska-Curie Bialystok Oncology Center, 15-027 Bialystok, Poland.
Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, 00-136 Warsaw, Poland.
ORCID: 0000-0002-0973-5455

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