A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers.
Animals
Humans
Mice
Anti-Bacterial Agents
/ adverse effects
Bacteria
/ immunology
Cell Adhesion Molecules
/ metabolism
Cell Movement
Drug Resistance, Neoplasm
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
/ immunology
Immune Checkpoint Inhibitors
/ therapeutic use
Immune Tolerance
/ drug effects
Immunologic Surveillance
Integrins
/ metabolism
Interleukin-17
/ metabolism
Mucoproteins
/ metabolism
Neoplasms
/ immunology
Th17 Cells
/ immunology
Gastrointestinal Tract
/ immunology
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
09 06 2023
09 06 2023
Historique:
medline:
12
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects remain unknown. By inducing the down-regulation of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in the ileum, post-ABX gut recolonization by
Identifiants
pubmed: 37289890
doi: 10.1126/science.abo2296
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cell Adhesion Molecules
0
Immune Checkpoint Inhibitors
0
integrin alpha4beta7
0
Integrins
0
Interleukin-17
0
MADCAM1 protein, human
0
Mucoproteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabo2296Commentaires et corrections
Type : CommentIn