A combined

AKT1 MD simulations SDF docking piperine prostate cancer

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
05 Jun 2023
Historique:
medline: 5 6 2023
pubmed: 5 6 2023
entrez: 5 6 2023
Statut: aheadofprint

Résumé

The present study investigates the activity of the natural compound piperine on prostate cancer cell line (PC-3), followed by exploring its mechanistic inhibition on the RAC-alpha serine/threonine-protein kinase (AKT1) protein. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay showed that after 24 hrs of exposure to piperine (15 µmol/ml), cell viability fell to 50% compared to the standard drug flutamide (SDF) (51 µmol/ml) with a lower IC

Identifiants

DOI: 10.1080/07391102.2023.2220045 PMID: 37272194
pubmed: 37272194
doi: 10.1080/07391102.2023.2220045
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-14

Auteurs

Prakash Nayana (P)

Department of PG studies and research in Biotechnology, Kuvempu University, Shivamogga, Karnataka, India.

Hanumanthappa Manjunatha (H)

Department of Biochemistry, Bangalore University, Bangalore, Karnataka, India.

Pavan Gollapalli (P)

Center for Bioinformatics and Biostatistics, Nitte (Deemed to be University), Mangalore, Karnataka, India.

Avinash Karkada Ashok (AK)

Department of Biotechnology, Siddaganga Institute of Technology, Tumakuru, Karnataka, India.

Preema Karal Andrade (P)

Department of PG studies and research in Biotechnology, Kuvempu University, Shivamogga, Karnataka, India.

Vijayalaksmi V (V)

Department of PG studies and research in Biotechnology, Kuvempu University, Shivamogga, Karnataka, India.

Classifications MeSH