Mucosal Genes Expression in Inflammatory Bowel Disease Patients: New Insights.
5-ASA
Crohn’s disease
anti-TNF
gene expression
ulcerative colitis
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
20 Feb 2023
20 Feb 2023
Historique:
received:
12
01
2023
revised:
03
02
2023
accepted:
16
02
2023
medline:
1
6
2023
pubmed:
1
6
2023
entrez:
1
6
2023
Statut:
epublish
Résumé
Individual differences in IBD illness severity, behavior, progression, and therapy response are evident. Since a break in the intestinal epithelial barrier causes IBD to begin, mucosal gene expression in IBD is crucial. Due to its high sensitivity and dynamic nature, molecular analysis of biomarkers in intestinal biopsies is feasible and provides a reliable means of evaluating localized inflammation. The goal of this investigation was to discover alterations in gene expression in the inflamed mucosa of IBD patients undergoing treatment with 5-amino salicylic acid (5ASA) (N = 39) or anti-TNF drugs (N = 22). The mucosal expression of numerous IBD-related genes was evaluated using qPCR. We discovered that the levels of the proteins Lipocalin-2 (LCN2), Nitric Oxide Synthase 2 (NOS2), Mucin 2 (MUC2), Mucin 5AC (MUC5AC), and Trefoil factor 1 (TFF1), which are overexpressed in untreated IBD patients compared to non-IBD subjects, are decreased by both therapy regimens. On the other hand, anti-TNF medicine helped the levels of ABCB1 and E-cadherin return to normal in IBD patients who were not receiving treatment.
Identifiants
pubmed: 37259466
pii: ph16020324
doi: 10.3390/ph16020324
pmc: PMC9966817
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R167),
ID : (PNURSP2023R167)
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