The Overlap of Diabetes and Osteoarthritis in American Populations.
diabetes mellitus
inflammatory cytokines
obesity
osteoarthritis
oxidative stress
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
30
12
2022
accepted:
28
04
2023
medline:
31
5
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
Diabetes mellitus, a condition in which the body's ability to produce insulin is impaired, and osteoarthritis (OA), a painful degeneration of joint cartilage, are both serious conditions that affect millions of people in the United States (U.S.). Osteoarthritis is a chronic degenerative condition of the joint cartilage, affecting mainly the older population. The purpose of this paper is to find a connection, if any, between diabetes and osteoarthritis and if either condition can predispose an individual to the other. Not only can this review help to explain the co-existence of these two diseases, but it can also be used to look into a cure for patients in the future. After preliminary searches were done on PubMed, results were narrowed using specific keywords and similar risk factors among the two diseases. It was found that these two conditions are actually interrelated due to oxidative stress and pro-inflammatory cytokines. Seeing the high risk of developing one of these conditions and that obesity, one of the biggest risk factors for both diabetes and osteoarthritis, is at an all-time high in this country, a possible connection between the two of these diseases is very prevalent to look into. This information can be used to help correlate not only a better-targeted treatment but also lead to future research into why obesity is one of the biggest risk factors for both conditions.
Identifiants
pubmed: 37255905
doi: 10.7759/cureus.38287
pmc: PMC10226284
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e38287Informations de copyright
Copyright © 2023, Nadella et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Rev Recent Clin Trials. 2018;13(3):210-214
pubmed: 29542422
Semin Arthritis Rheum. 2016 Dec;46(3):259-260
pubmed: 27519477
Inflamm Res. 2018 Apr;67(4):285-300
pubmed: 29196771
Diabetes Res Clin Pract. 2016 Dec;122:198-206
pubmed: 27889689
Clin Chim Acta. 2012 Aug 16;413(15-16):1163-70
pubmed: 22521751
EClinicalMedicine. 2020 Nov 26;29-30:100587
pubmed: 34505846
J Nutr Metab. 2020 May 21;2020:4143802
pubmed: 32566279
MMWR Morb Mortal Wkly Rep. 2019 May 03;68(17):381-387
pubmed: 31048678
Semin Arthritis Rheum. 2019 Aug;49(1):9-19
pubmed: 30712918
Curr Diabetes Rev. 2017;13(1):50-58
pubmed: 26593984
Nat Rev Immunol. 2011 Feb;11(2):85-97
pubmed: 21252989
Clin Geriatr Med. 2015 Feb;31(1):67-87, viii
pubmed: 25453302
Trends Endocrinol Metab. 2015 Oct;26(10):551-563
pubmed: 26412156
Diabetes Res Clin Pract. 2019 Nov;157:107843
pubmed: 31518657
J Diabetes Res. 2019 Dec 06;2019:6324348
pubmed: 31886282
Medicine (Abingdon). 2014 Dec;42(12):698-702
pubmed: 25568613
J Clin Med. 2019 Sep 04;8(9):
pubmed: 31487953
RMD Open. 2015 Jun 02;1(1):e000077
pubmed: 26535137
Diabetes Care. 2020 Nov 2;:
pubmed: 33139407
Arthritis Res Ther. 2009;11(3):227
pubmed: 19519925
Arch Phys Med Rehabil. 2021 Jan;102(1):115-131
pubmed: 32339483