Synthesis and Antiproliferative Insights of Lipophilic Ru(II)-Hydroxy Stearic Acid Hybrid Species.
DNA damage
Ru(II)
alkyl chain
anticancer
hydroxy stearic acid
lipophilicity
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 May 2023
12 May 2023
Historique:
received:
08
04
2023
revised:
08
05
2023
accepted:
10
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Metallodrugs represent a combination of multifunctionalities that are present concomitantly and can act differently on diverse biotargets. Their efficacy is often related to the lipophilic features exhibited both by long carbo-chains and the phosphine ligands. Three Ru(II) complexes containing hydroxy stearic acids (HSAs) were successfully synthesized in order to evaluate possible synergistic effects between the known antitumor activity of HSA bio-ligands and the metal center. HSAs were reacted with [Ru(H)
Identifiants
pubmed: 37241793
pii: molecules28104051
doi: 10.3390/molecules28104051
pmc: PMC10222286
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ruthenium
7UI0TKC3U5
Ligands
0
Coordination Complexes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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