Possible role of transient receptor potential melastatin 4 channels in adrenergic contractions in mouse prostate smooth muscles.
9-phenanthrol
adrenergic contraction
cardiovascular system
mouse prostate smooth muscle
transient receptor potential melastatin 4 channel
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
01 Jul 2023
01 Jul 2023
Historique:
medline:
4
7
2023
pubmed:
25
5
2023
entrez:
24
5
2023
Statut:
ppublish
Résumé
Transient receptor potential melastatin 4 (TRPM4) cation channels are expressed in prostate glands. However, the precise role of these channels in prostate contractility remains unclear. In this study, we examined whether TRPM4 channels were involved in adrenergic contractions in the mouse prostate gland. Adrenergic contractile responses elicited by noradrenaline or electrical field stimulation of the sympathetic nerve were isometrically recorded, and the effects of 9-phenanthrol, a specific TRPM4 channel inhibitor, on those contractile responses were investigated in mouse ventral prostate preparations. 9-phenanthrol (10 or 30 μM) inhibited noradrenaline- and sympathetic nerve-evoked contractions in a concentration-dependent manner. A similar inhibitory effect was observed with another TRPM4 channel inhibitor, 4-chloro-2-(2-(naphthalene-1-yloxy) acetamido) benzoic acid (NBA; 10 μM). Inhibition by 9-phenanthrol and NBA were much greater at lower noradrenaline concentrations and lower stimulus frequencies than those of higher concentrations or frequencies. However, 9-phenanthrol did not inhibit the noradrenaline-induced contractile response when the membrane potential was decreased to approximately 0 mV in the 140 mM K
Identifiants
pubmed: 37225446
doi: 10.1292/jvms.23-0112
pmc: PMC10372249
doi:
Substances chimiques
9-phenanthrol
9FYU45OV9H
Transient Receptor Potential Channels
0
Adrenergic Agents
0
TRPM Cation Channels
0
Norepinephrine
X4W3ENH1CV
TRPM4 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
705-714Références
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