Reliability of resting-state EEG modulation by continuous and intermittent theta burst stimulation of the primary motor cortex: A sham-controlled study.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
12 May 2023
Historique:
pubmed: 22 5 2023
medline: 22 5 2023
entrez: 22 5 2023
Statut: epublish

Résumé

Theta burst stimulation (TBS) is a form of repetitive transcranial magnetic stimulation designed to induce changes of cortical excitability that outlast the period of TBS application. In this study, we explored the effects of continuous TBS (cTBS) and intermittent TBS (iTBS) versus sham TBS stimulation, applied to the primary motor cortex, on modulation of resting state electroencephalography (rsEEG) power. We first conducted hypothesis-driven region-of-interest (ROI) analyses examining changes in alpha (8-12 Hz) and beta (13-21 Hz) bands over the left and right motor cortex. Additionally, we performed data-driven whole-brain analyses across a wide range of frequencies (1-50 Hz) and all electrodes. Finally, we assessed the reliability of TBS effects across two sessions approximately 1 month apart. None of the protocols produced significant group-level effects in the ROI. Whole-brain analysis revealed that cTBS significantly enhanced relative power between 19-43 Hz over multiple sites in both hemispheres. However, these results were not reliable across visits. There were no significant differences between EEG modulation by active and sham TBS protocols. Between-visit reliability of TBS-induced neuromodulatory effects was generally low-to-moderate. We discuss confounding factors and potential approaches for improving the reliability of TBS-induced rsEEG modulation.

Identifiants

pubmed: 37215043
doi: 10.1101/2023.05.12.540024
pmc: PMC10197617
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : P01 AG031720
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060981
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060987
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115949
Pays : United States

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Competing interests Dr. A. Pascual-Leone is a co-founder of Linus Health and TI Solutions AG; serves on the scientific advisory boards for Starlab Neuroscience, Neuroelectrics, Magstim Inc., Nexstim, Cognito, and MedRhythms; and is listed as an inventor on several issued and pending patents on the real-time integration of noninvasive brain stimulation with electroencephalography and magnetic resonance imaging.

Auteurs

Andrei Rodionov (A)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.

Recep A Ozdemir (RA)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.

Christopher S Y Benwell (CSY)

Division of Psychology, School of Humanities, Social Sciences and Law, University of Dundee, Dundee, UK.

Peter J Fried (PJ)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.

Pierre Boucher (P)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Davide Momi (D)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.
Krembil Centre for Neuroinformatics, Centre for Addiction & Mental Health, Toronto.

Jessica M Ross (JM)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.
Veterans Affairs Palo Alto Healthcare System, and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center, Palo Alto, CA, USA.
Department of Psychiatry and Behavioral Sciences, Stanford Medical School, Stanford, CA, USA.

Emiliano Santarnecchi (E)

Department of Neurology, Harvard Medical School, Boston, MA, USA.
Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Alvaro Pascual-Leone (A)

Department of Neurology, Harvard Medical School, Boston, MA, USA.
Hinda and Arthur Marcus Institute for Aging Research, Deanna and Sidney Wolk Center for Memory Health, Hebrew Senior Life, Boston, MA, USA.

Mouhsin M Shafi (MM)

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.

Classifications MeSH