Late-life depressive symptoms and white matter structural integrity within older Black adults.
African-American
Black
brain structure
diffusion-tensor imaging
late-life depressive symptoms
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
01
2023
accepted:
12
04
2023
medline:
19
5
2023
pubmed:
19
5
2023
entrez:
19
5
2023
Statut:
epublish
Résumé
Older Black adults experience a high burden of depressive symptoms and cerebrovascular disease but the specific neurobiological substrates underlying the association between late-life depressive symptoms and brain integrity are understudied, particularly in within-group designs. Using the Center for Epidemiologic Studies Depression Scale and diffusion-tensor imaging, within-Black variation in the association between late-life depressive symptoms and white matter structural integrity was examined in 297 older Black participants without dementia that were enrolled across three epidemiological studies of aging and dementia. Linear regression models were used to test associations with DTI metrics (fractional anisotropy, trace of the diffusion tensor) as the outcomes and depressive symptoms as the predictor, while adjusting for age, sex, education, scanner, serotonin-reuptake inhibitor use, total volume of white-matter hyperintensities normalized by intracranial volume, and presence of white-matter hyperintensities at the voxel level. Higher level of self-reported late-life depressive symptoms was associated with greater diffusion-tensor trace (reduced white matter integrity) in connections between commissural pathways and contralateral prefrontal regions (superior and middle frontal/dorsolateral prefrontal cortex), association pathways connecting dorsolateral prefrontal cortex with insular, striatal and thalamic regions, and association pathways connecting the parietal, temporal and occipital lobes and the thalamus. This study demonstrated a discernable pattern of compromised white matter structural integrity underlying late-life depressive symptoms within older Black adults.
Identifiants
pubmed: 37205056
doi: 10.3389/fnagi.2023.1138568
pmc: PMC10186351
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1138568Subventions
Organisme : NIA NIH HHS
ID : K01 AG064044
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072975
Pays : United States
Informations de copyright
Copyright © 2023 Fleischman, Arfanakis, Leurgans, Zhang, Lamar, Han, Poole, Kim, Bennett and Barnes.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
BMC Med. 2016 Nov 3;14(1):161
pubmed: 27806704
JAMA Psychiatry. 2017 Jul 1;74(7):729-739
pubmed: 28564681
Clin Neuropsychol. 2022 Feb;36(2):431-461
pubmed: 34098846
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 May;1(3):271-277
pubmed: 27430029
J Health Soc Behav. 2009 Mar;50(1):82-98
pubmed: 19413136
Circulation. 2021 Feb 23;143(8):e254-e743
pubmed: 33501848
Hum Brain Mapp. 2010 Mar;31(3):378-90
pubmed: 19662658
Neurotherapeutics. 2007 Jul;4(3):316-29
pubmed: 17599699
Transl Psychiatry. 2019 Aug 5;9(1):188
pubmed: 31383842
Stroke. 2009 Dec;40(12):3869-71
pubmed: 19850898
J Aging Health. 2021 Jun-Jul;33(5-6):310-316
pubmed: 33345681
J Aging Health. 1993 May;5(2):179-93
pubmed: 10125443
J Geriatr Psychiatry Neurol. 2014 Mar;27(1):5-12
pubmed: 24381233
Neurology. 2010 Jul 6;75(1):21-6
pubmed: 20603481
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Br J Psychiatry. 2010 May;196(5):365-71
pubmed: 20435961
Br J Psychiatry. 2013 May;202(5):329-35
pubmed: 23637108
Curr Alzheimer Res. 2012 Jul;9(6):734-45
pubmed: 22471868
J Alzheimers Dis. 2015;50(1):71-6
pubmed: 26639973
J Magn Reson Imaging. 2001 Apr;13(4):534-46
pubmed: 11276097
J Affect Disord. 2020 Apr 1;266:243-251
pubmed: 32056884
Ann N Y Acad Sci. 2008 Oct;1142:266-309
pubmed: 18990132
AJNR Am J Neuroradiol. 2015 Sep;36(9):1648-53
pubmed: 26206811
Neuroimage. 2016 Nov 1;141:502-516
pubmed: 27288322
Circulation. 2017 Nov 21;136(21):e393-e423
pubmed: 29061565
Am J Geriatr Psychiatry. 2010 Feb;18(2):98-116
pubmed: 20104067
J Int Neuropsychol Soc. 2012 Sep;18(5):856-65
pubmed: 22595035
Psychol Aging. 2011 Dec;26(4):761-77
pubmed: 21875216
J Gerontol B Psychol Sci Soc Sci. 2005 May;60(3):P136-42
pubmed: 15860783
Psychol Med. 1997 Nov;27(6):1397-409
pubmed: 9403911
Brain Struct Funct. 2008 Sep;213(1-2):93-118
pubmed: 18704495
J Magn Reson B. 1996 Jun;111(3):209-19
pubmed: 8661285
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Neuroimage. 2015 Dec;123:253-68
pubmed: 26074200
Arch Neurol. 2008 Aug;65(8):1053-61
pubmed: 18695055
BMJ. 2009 Aug 17;339:b3016
pubmed: 19687093
Front Neurosci. 2020 Apr 17;14:253
pubmed: 32362808
Am J Epidemiol. 2019 Feb 1;188(2):314-322
pubmed: 30358803
J Community Psychol. 2019 Mar;47(2):227-237
pubmed: 30706518
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Acta Psychiatr Scand. 2004 May;109(5):325-31
pubmed: 15049768
Health Aff (Millwood). 2014 Apr;33(4):580-6
pubmed: 24711318
Int J Geriatr Psychiatry. 2014 Dec;29(12):1173-84
pubmed: 24798480
Soc Ment Health. 2013 Jul 1;3(2):
pubmed: 24224131
Int J Geriatr Psychiatry. 2001 Jun;16(6):622-30
pubmed: 11424172
J Affect Disord. 2021 Jan 15;279:510-517
pubmed: 33130551
Race Soc Probl. 2020 Jun;12(2):133-144
pubmed: 34084252
J Gen Intern Med. 1998 Nov;13(11):746-52
pubmed: 9824520
Neurology. 2022 Jul 19;99(3):106-114
pubmed: 35851551
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110010
pubmed: 32544600
Am J Psychiatry. 1997 Apr;154(4):497-501
pubmed: 9090336
Mol Psychiatry. 2013 Sep;18(9):963-74
pubmed: 23439482
Diabetes Care. 2016 Jan;39(1):101-9
pubmed: 26577418
Eur Psychiatry. 2019 Oct;62:90-96
pubmed: 31550583
J Diabetes Complications. 2018 Oct;32(10):916-921
pubmed: 30042057
J Alzheimers Dis. 2018;64(s1):S161-S189
pubmed: 29865057
Curr Alzheimer Res. 2015;12(7):632-9
pubmed: 26027808
Curr Opin Neurobiol. 2003 Apr;13(2):219-24
pubmed: 12744977
Am J Geriatr Psychiatry. 2015 Jun;23(6):568-78
pubmed: 25214029
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Curr Opin Cardiol. 2020 Jul;35(4):342-350
pubmed: 32398604
Curr Opin Neurobiol. 2001 Apr;11(2):157-63
pubmed: 11301234
Radiol Open J. 2015;1(1):1-12
pubmed: 27077135
J Neurosci. 2008 Jan 23;28(4):923-31
pubmed: 18216200
J Am Heart Assoc. 2015 Jun 23;4(6):001140
pubmed: 26104658
J Neurophysiol. 2016 Nov 1;116(5):2093-2104
pubmed: 27512019
Curr Alzheimer Res. 2015;12(7):640-7
pubmed: 26239040
Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H777-H789
pubmed: 31397168
Prog Mol Biol Transl Sci. 2019;165:3-23
pubmed: 31481168
Stroke. 2010 Jan;41(1):3-8
pubmed: 19926835
Psychiatry Res. 2004 Apr 30;126(2):177-87
pubmed: 15123397
Int J Geriatr Psychiatry. 2013 Sep;28(9):903-13
pubmed: 23225736
Learn Mem. 2016 Sep 15;23(10):504-14
pubmed: 27634142
Cereb Cortex. 2009 Mar;19(3):524-36
pubmed: 18567609
Neuroimage Clin. 2019;22:101710
pubmed: 30849644
JAMA. 2011 Sep 21;306(11):1241-9
pubmed: 21934057
Neuroimage. 2016 Nov 1;141:191-205
pubmed: 27402600
Psychosom Med. 2009 Jul;71(6):652-8
pubmed: 19483119
Br J Psychiatry. 2019 Aug;215(2):449-455
pubmed: 30968781
Neuroimage. 2018 May 15;172:40-50
pubmed: 29414497
J Affect Disord. 2018 Dec 1;241:206-215
pubmed: 30130686
Int J Geriatr Psychiatry. 2014 May;29(5):470-7
pubmed: 24123266
Alzheimers Dement. 2019 Jan;15(1):1-7
pubmed: 30195482
Am J Geriatr Psychiatry. 2010 Jul;18(7):634-42
pubmed: 20220594
JAMA Psychiatry. 2022 Jan 1;79(1):70-74
pubmed: 34613345
Am J Hypertens. 2018 Jul 16;31(8):865-868
pubmed: 29672672
J Diabetes Complications. 2017 Aug;31(8):1259-1265
pubmed: 28433449
Neurosci Lett. 2007 May 29;419(2):113-8
pubmed: 17485168
Cerebrovasc Dis. 2014;37(4):244-50
pubmed: 24686322
Neurology. 2008 Feb 5;70(6):425-30
pubmed: 17898325