Temocillin Resistance in the Enterobacter cloacae Complex Is Conferred by a Single Point Mutation in BaeS, Leading to Overexpression of the AcrD Efflux Pump.

Membrane Transport Proteins / genetics Anti-Bacterial Agents / pharmacology Enterobacter cloacae / genetics Escherichia coli / genetics Point Mutation Microbial Sensitivity Tests
AcrD BaeSR E. asburiae ECC MdtABCD

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
15 06 2023
Historique:
medline: 19 6 2023
pubmed: 17 5 2023
entrez: 17 5 2023
Statut: ppublish

Résumé

The Enterobacter cloacae complex (ECC) has become a major opportunistic pathogen with antimicrobial resistance issues. Temocillin, an "old" carboxypenicillin that is remarkably stable toward β-lactamases, has been used as an alternative for the treatment of multidrug-resistant ECC infections. Here, we aimed at deciphering the never-investigated mechanisms of temocillin resistance acquisition in

Identifiants

DOI: 10.1128/aac.00358-23 PMID: 37195180 PMC: PMC10269110
pubmed: 37195180
doi: 10.1128/aac.00358-23
pmc: PMC10269110
doi:

Substances chimiques

Membrane Transport Proteins 0
Anti-Bacterial Agents 0
temocillin 03QB156W6I

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0035823

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

François Guérin (F)

Department of Clinical Microbiology, Rennes University Hospital, Rennes, France.
University of Rennes, INSERM UMR 1230 BRM, Rennes, France.

François Gravey (F)

Normandie Université, UNICAEN, UNIROUEN, INSERM UMR 1311 DYNAMICURE, Caen, France.
Microbiology Department, CHU Caen, Caen, France.
ORCID: 0000-0001-8672-8286

Sophie Reissier (S)

Department of Clinical Microbiology, Rennes University Hospital, Rennes, France.
University of Rennes, INSERM UMR 1230 BRM, Rennes, France.

Malo Penven (M)

Department of Clinical Microbiology, Rennes University Hospital, Rennes, France.
University of Rennes, INSERM UMR 1230 BRM, Rennes, France.

Charlotte Michaux (C)

University of Rennes, INSERM UMR 1230 BRM, Rennes, France.

Simon Le Hello (S)

Normandie Université, UNICAEN, UNIROUEN, INSERM UMR 1311 DYNAMICURE, Caen, France.
Microbiology Department, CHU Caen, Caen, France.

Vincent Cattoir (V)

Department of Clinical Microbiology, Rennes University Hospital, Rennes, France.
University of Rennes, INSERM UMR 1230 BRM, Rennes, France.
ORCID: 0000-0003-4026-9912

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Temocillin Resistance in the Enterobacter...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Temocillin Resistance in the Enterobacter...
Recherchemedicale.com › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Enterobacter › Enterobacter cloacae › Temocillin Resistance in the Enterobacter...
Recherchemedicale.com › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Temocillin Resistance in the Enterobacter...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Mutation ponctuelle › Temocillin Resistance in the Enterobacter...
Recherchemedicale.com › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Temocillin Resistance in the Enterobacter...