Synthesis and Evaluation of
FAP inhibitors (FAPIs)
Gallium-68
PET imaging
cancer-associated fibroblasts (CAFs)
fibroblast activation protein α (FAP-α)
targeted radiopharmaceuticals
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Apr 2023
14 Apr 2023
Historique:
received:
18
03
2023
revised:
08
04
2023
accepted:
12
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Fibroblast activation protein α (FAP-α) is a cell-surface protein overexpressed on cancer-associated fibroblasts that constitute a substantial component of tumor stroma and drive tumorigenesis. FAP is minimally expressed by most healthy tissues, including normal fibroblasts. This makes it a promising pan-cancer diagnostic and therapeutic target. In the present study, we synthesized two novel tracers, [
Identifiants
pubmed: 37110717
pii: molecules28083481
doi: 10.3390/molecules28083481
pmc: PMC10145249
pii:
doi:
Substances chimiques
Gallium Radioisotopes
0
Thiazolidines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-180300
Pays : Canada
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