Spinal Cord Stimulation Prevents Autonomic Dysreflexia in Individuals with Spinal Cord Injury: A Case Series.
autonomic dysreflexia
cardiovascular function
epidural stimulation
spinal cord injury
spinal cord stimulation
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
16 Apr 2023
16 Apr 2023
Historique:
received:
03
03
2023
revised:
04
04
2023
accepted:
12
04
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Spinal cord injury (SCI) results in severe cardiovascular dysfunction due to the disruption of supraspinal control. Autonomic dysreflexia (AD), an uncontrolled rise in blood pressure in response to peripheral stimuli including common bowel routine, digital anorectal stimulation (DARS), reduces the quality of life, and increases morbidity and mortality. Recently, spinal cord stimulation (SCS) has emerged as a potential intervention to mitigate unstable blood pressure following SCI. The objective of this case series was to test the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord, the most common implant location, on mitigating AD in individuals with SCI. We recruited three individuals with cervical and upper thoracic motor-complete SCI who have an implanted epidural stimulator. We demonstrated that eSCS can reduce the elevation in blood pressure and prevent DARS-induced AD. The blood pressure variability analysis indicated that eSCS potentially reduced vascular sympathetic nervous system activity during DARS, compared to without eSCS. This case series provides evidence to support the use of eSCS to prevent AD episodes during routine bowel procedures, improving the quality of life for individuals with SCI and potentially reducing cardiovascular risks.
Identifiants
pubmed: 37109234
pii: jcm12082897
doi: 10.3390/jcm12082897
pmc: PMC10146034
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Canadian Foundation of Innovation
ID : na
Organisme : Canadian Institute for Health Research
ID : na
Organisme : BC Knowledge Development Fund
ID : na
Organisme : Spinal Research
ID : na
Organisme : Rick Hansen Foundation
ID : na
Organisme : Praxis Spinal Cord Institute
ID : na
Organisme : Wings for Life
ID : na
Organisme : Congressionally Directed Medical Research Programs
ID : na
Organisme : Paralyzed Veterans of America
ID : na
Références
J Neurotrauma. 2012 May 20;29(8):1548-55
pubmed: 22320160
Top Spinal Cord Inj Rehabil. 2021 Spring;27(2):225-290
pubmed: 34108837
Spinal Cord. 2010 Jun;48(6):504-10
pubmed: 19949417
Nat Neurosci. 2016 Jun;19(6):784-7
pubmed: 27089020
Nat Med. 2022 Feb;28(2):260-271
pubmed: 35132264
J Neurotrauma. 2019 Aug 1;36(15):2325-2336
pubmed: 30667299
Brain. 1986 Aug;109 ( Pt 4):695-715
pubmed: 3730811
Exp Neurol. 2020 May;327:113235
pubmed: 32044331
Circ Res. 1986 Aug;59(2):178-93
pubmed: 2874900
Spinal Cord. 2005 Jul;43(7):408-16
pubmed: 15711609
J Neurotrauma. 2004 Oct;21(10):1371-83
pubmed: 15672628
Neurology. 2012 Apr 3;78(14):1051-7
pubmed: 22377807
Annu Rev Physiol. 1988;50:577-92
pubmed: 3288107
Top Spinal Cord Inj Rehabil. 2021 Spring;27(2):23-49
pubmed: 34108833
Exp Neurol. 2022 Nov;357:114178
pubmed: 35878817
J Spinal Cord Med. 2014 Jan;37(1):2-10
pubmed: 24090418
Sci Rep. 2022 Jul 1;12(1):11179
pubmed: 35778466
JAMA Neurol. 2018 Dec 1;75(12):1569-1571
pubmed: 30242310
Arch Phys Med Rehabil. 2005 Mar;86(3):591-3
pubmed: 15759250
Brain. 1947 Dec;70(Pt 4):361-404
pubmed: 18903252
Nature. 2021 Feb;590(7845):308-314
pubmed: 33505019
J Neurosci. 2009 Jan 21;29(3):686-95
pubmed: 19158295
Arch Phys Med Rehabil. 1991 Jul;72(8):592-4
pubmed: 2059140
Arch Phys Med Rehabil. 2021 Jun;102(6):1155-1164
pubmed: 33161007
Am J Phys Med Rehabil. 2007 Feb;86(2):142-52
pubmed: 17251696
Pain. 1997 Oct;73(1):87-95
pubmed: 9414060
Neuroscientist. 2023 Jan 11;:10738584221145570
pubmed: 36631741
Neurology. 2013 Aug 20;81(8):723-8
pubmed: 23884034
Respir Physiol Neurobiol. 2009 Nov 30;169(2):157-64
pubmed: 19682607
Neuroscience. 1996 Jan;70(1):211-25
pubmed: 8848126
Neurotherapeutics. 2021 Apr;18(2):1244-1256
pubmed: 33791969
J Neurosurg. 2004 Mar;100(3 Suppl Spine):254-67
pubmed: 15029914
Exp Physiol. 2007 Jul;92(4):677-86
pubmed: 17468200
Spinal Cord. 2014 Jun;52(6):494-8
pubmed: 24777164
Arch Phys Med Rehabil. 1999 Nov;80(11):1411-9
pubmed: 10569435
Neurosci Lett. 1998 Feb 27;243(1-3):61-4
pubmed: 9535113
Top Spinal Cord Inj Rehabil. 2021 Spring;27(2):1-22
pubmed: 34108832
Anesth Analg. 1967 Jul-Aug;46(4):489-91
pubmed: 4952225
Neuroscience. 1998 Jul;85(2):443-58
pubmed: 9622243
J Neurotrauma. 2018 May 1;35(9):1091-1105
pubmed: 29239268
J Neurotrauma. 2002 Dec;19(12):1521-9
pubmed: 12542854
J Neurol Neurosurg Psychiatry. 1997 May;62(5):473-7
pubmed: 9153603
Am J Physiol. 1997 Sep;273(3 Pt 2):H1266-74
pubmed: 9321815
Arch Phys Med Rehabil. 2009 Apr;90(4):682-95
pubmed: 19345787
Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H668-78
pubmed: 18024546
JAMA. 1996 Oct 23-30;276(16):1328-31
pubmed: 8861992
Nat Med. 2018 Nov;24(11):1677-1682
pubmed: 30250140
N Engl J Med. 2018 Sep 27;379(13):1244-1250
pubmed: 30247091
Spinal Cord. 2009 Apr;47(4):323-30; quiz 331-3
pubmed: 19015665
Rehabil Nurs. 2012 May-Jun;37(3):128-35
pubmed: 22549630
J Comp Neurol. 2008 Aug 1;509(4):382-99
pubmed: 18512692
Front Physiol. 2018 Dec 18;9:1816
pubmed: 30618826
Am J Hypertens. 2015 Feb;28(2):173-81
pubmed: 24990527
Neurosurgery. 1979 Jun;4(6):517-20
pubmed: 314604
Science. 1965 Nov 19;150(3699):971-9
pubmed: 5320816