Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma.
activin A
cancer-associated fibroblasts
cholesterol-modified polymeric nanoparticle
orthotopic mice
pancreatic ductal adenocarcinoma
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
22
03
2023
received:
28
11
2022
medline:
5
6
2023
pubmed:
21
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among PDAC patients. However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. In orthotopic male mice, activin A suppression, which is acquired by tumor-targeted Inhba siRNA using cholesterol-modified polymeric nanoparticles, retards tumor growth/metastasis and cachexia and improves survival when compared to scramble siRNA-treated group. Histologically, activin A suppression coincides with decreased expression of proliferation marker Ki67 but increased accumulation of α-SMA
Identifiants
pubmed: 37083240
doi: 10.1002/advs.202207010
pmc: PMC10238186
doi:
Substances chimiques
activin A
0
inhibin beta A subunit
0
RNA, Small Interfering
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2207010Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
Biol Reprod. 2013 Apr 04;88(4):86
pubmed: 23446452
Front Oncol. 2021 Jul 15;11:688377
pubmed: 34336673
Nat Commun. 2021 Oct 5;12(1):5826
pubmed: 34611171
Mol Oncol. 2013 Apr;7(2):232-47
pubmed: 23506980
Cancers (Basel). 2014 Dec 30;7(1):70-91
pubmed: 25560921
Mol Cell Endocrinol. 2013 Jun 15;372(1-2):57-64
pubmed: 23567549
Gastroenterology. 2018 Sep;155(3):880-891.e8
pubmed: 29909021
Gastroenterology. 2016 Jan;150(1):218-228.e12
pubmed: 26408346
Cells. 2020 Apr 22;9(4):
pubmed: 32331358
Commun Biol. 2023 Jan 12;6(1):34
pubmed: 36635368
Oncol Rev. 2019 Feb 01;13(1):410
pubmed: 31044028
Cancers (Basel). 2021 Sep 30;13(19):
pubmed: 34638420
Biosci Rep. 2022 Feb 25;42(2):
pubmed: 35083488
Genome Med. 2020 Sep 29;12(1):80
pubmed: 32988401
Clin Cancer Res. 2021 Dec 15;27(24):6787-6799
pubmed: 34615717
Lab Invest. 2014 Jun;94(6):683-91
pubmed: 24709776
Cancer Cell. 2014 Jun 16;25(6):719-34
pubmed: 24856586
Cancer Lett. 2019 Mar 1;444:70-81
pubmed: 30590101
Physiol Rev. 2019 Jan 1;99(1):739-780
pubmed: 30540228
J Exp Med. 2017 Mar 6;214(3):579-596
pubmed: 28232471
Pathobiology. 2018;85(1-2):64-71
pubmed: 28787741
Front Oncol. 2021 Apr 13;11:646399
pubmed: 33928036
Gastroenterology. 2013 Jun;144(6):1194-8
pubmed: 23622128
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
J Biol Chem. 2005 Mar 11;280(10):9135-48
pubmed: 15613482
J Pathol. 2013 Mar;229(4):599-607
pubmed: 23180294
Mol Endocrinol. 2006 Nov;20(11):2848-63
pubmed: 16873442
Cancer Res. 2020 Aug 15;80(16):3359-3371
pubmed: 32554750
Cancer Cell Int. 2017 Jul 5;17:68
pubmed: 28694739
Adv Sci (Weinh). 2023 Jun;10(16):e2207010
pubmed: 37083240
Front Cell Dev Biol. 2021 Jul 15;9:655152
pubmed: 34336821
Cells. 2019 Sep 20;8(10):
pubmed: 31547193
Genes Dev. 2006 Nov 15;20(22):3130-46
pubmed: 17114584
Cancers (Basel). 2021 Oct 08;13(19):
pubmed: 34638513
Am J Cancer Res. 2020 Jul 01;10(7):1937-1953
pubmed: 32774994
EBioMedicine. 2021 Apr;66:103315
pubmed: 33819739
J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1083-1101
pubmed: 31286691
Sci Rep. 2022 Jan 31;12(1):1659
pubmed: 35102236
Cancer Lett. 2015 Jan 28;356(2 Pt B):819-27
pubmed: 25449777
Sci Rep. 2021 Apr 12;11(1):7986
pubmed: 33846512
Gastroenterology. 2021 Jan;160(1):346-361.e24
pubmed: 33007300
ACS Nano. 2020 Jan 28;14(1):255-271
pubmed: 31927946
J Exp Med. 2021 Jun 7;218(6):
pubmed: 33851955
Aging (Albany NY). 2020 Nov 17;12(22):22564-22581
pubmed: 33201838
Cell Death Dis. 2021 Jun 25;12(7):649
pubmed: 34172716