[Relapse with HLA loss after hematopoietic stem cell transplantation with non-HLA identical donor].
Perte d’hétérozygotie HLA dans les rechutes après greffes de cellules souches hématopoïétiques avec donneur non HLA identique.
Greffe haplo-identique
HLA loss
Haplo-HSCT
Rechute
Relapse
Journal
Bulletin du cancer
ISSN: 1769-6917
Titre abrégé: Bull Cancer
Pays: France
ID NLM: 0072416
Informations de publication
Date de publication:
13 Apr 2023
13 Apr 2023
Historique:
received:
24
01
2023
revised:
13
03
2023
accepted:
15
03
2023
entrez:
15
4
2023
pubmed:
16
4
2023
medline:
16
4
2023
Statut:
aheadofprint
Résumé
Loss of heterozygosity or HLA loss is a genomic-type escape mechanism highlighted in certain types of relapses after allogeneic hematopoietic stem cell transplantation with a non-HLA identical donor, and especially after haplo-identical transplantation. The diagnosis must be made with certainty because the result conditions the therapy. In this article, the different mechanisms and techniques that can be used for the diagnosis of loss of heterozygosity, as well as the therapeutic options are reviewed, making it possible to establish clinico-biological recommendations for the diagnosis confirmation and management of the patients in relapse.
Identifiants
pubmed: 37061368
pii: S0007-4551(23)00158-3
doi: 10.1016/j.bulcan.2023.03.013
pii:
doi:
Types de publication
English Abstract
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.