A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential.
anti-allergic potential
cosmetics
resveratrol
safety profile
sensitization potential
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Apr 2023
02 Apr 2023
Historique:
received:
27
02
2023
revised:
27
03
2023
accepted:
31
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potential of this new compound using an in vitro approach based on the OECD 442E guideline. Furthermore, the anti-allergic potential of RSV-GS was also disclosed. The monocyte THP-1 cell line was stimulated with RSV and RSV-GS in the presence or absence of the extreme skin allergen 1-fluoro-2,4-dinitrobenzene (DNFB). The results demonstrated that RSV-GS alone (500 µM) evoked a relative fluorescence index (RFI) lower than the thresholds established by the OECD guideline for CD54 (200%) and CD86 (150%), indicating the absence of a skin sensitization potential. Interestingly, in the presence of the skin allergen DNFB, RSV-GS exhibited the ability to rescue the DNFB-induced maturation of THP-1 cells, with RFI values lower than those for RSV, suggesting the potential of RSV-GS to mitigate skin sensitization evoked by allergens and, consequently, allergic contact dermatitis. These results open new avenues for the use of RSV-GS as a safe and anti-allergic active cosmetic ingredient.
Identifiants
pubmed: 37049922
pii: molecules28073158
doi: 10.3390/molecules28073158
pmc: PMC10096149
pii:
doi:
Substances chimiques
Resveratrol
Q369O8926L
Anti-Allergic Agents
0
Sulfates
0
Dinitrofluorobenzene
D241E059U6
Allergens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Bio-sciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB
Organisme : Fundação para a Ciência e Tecnologia
ID : scope of UIDB/04423/2020, UIDP/04539/2020, UIDP/04423/2020 (Group of Marine Natural Products and Medicinal Chemistry-CIIMAR), as well as a structured program of R&D&I AT-LANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF
Organisme : European Regional Development Fund (ERDF)
ID : Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 (HealthyAging2020) and through the Northern Regional Operational Program (NORTE2020) under the project 47239-Cork2Cosmetic (NORTE-01-0247-FEDER-047239)
Organisme : Fundação para a Ciência e Tecnologia
ID : Ana Jesus, Ana I. Sebastião, and Gonçalo Brites acknowledge their Ph.D. grants (UI/BD/151319/2021, 2021.04586.BD, and PD/BDE/142926/2018, respectively)
Références
Toxicol Res (Camb). 2018 Jan 26;7(4):586-605
pubmed: 30090609
Molecules. 2021 Jun 11;26(12):
pubmed: 34208257
Curr Opin Biotechnol. 2012 Apr;23(2):174-81
pubmed: 21925860
Med Res Rev. 2014 Mar;34(2):223-79
pubmed: 23553315
Eur J Med Chem. 2011 Jun;46(6):2347-58
pubmed: 21450376
Biofouling. 2017 Nov;33(10):927-942
pubmed: 29171304
Nucleic Acids Res. 2021 Jul 2;49(W1):W5-W14
pubmed: 33893803
Biomed Pharmacother. 2022 Jul;151:113136
pubmed: 35594715
J Mol Endocrinol. 2018 Aug;61(2):M27-M39
pubmed: 29588426
J Mol Endocrinol. 2018 Aug;61(2):T211-T231
pubmed: 29298811
J Allergy Clin Immunol. 2022 Apr;149(4):1162-1171
pubmed: 35183605
Int J Toxicol. 2020 Nov/Dec;39(6):547-559
pubmed: 32757797
J Eur Acad Dermatol Venereol. 2022 Jul;36(7):1088-1096
pubmed: 35274366
J Med Chem. 2011 Jan 13;54(1):95-106
pubmed: 21138266
J AOAC Int. 2019 Sep 1;102(5):1397-1400
pubmed: 31200785
Contact Dermatitis. 2020 Jun;82(6):412-413
pubmed: 32060919
Nat Prod Res. 2019 Nov;33(22):3260-3272
pubmed: 29726719
Angew Chem Int Ed Engl. 2011 Jan 17;50(3):586-621
pubmed: 21226137
Free Radic Biol Med. 2014 Dec;77:217-29
pubmed: 25236743
Altern Lab Anim. 2010 Aug;38(4):275-84
pubmed: 20822320
Pharmacol Res. 2020 Dec;162:105282
pubmed: 33161140
Pharmaceutics. 2020 Sep 11;12(9):
pubmed: 32933004
Nutrients. 2019 Jan 11;11(1):
pubmed: 30641865
Metabolites. 2012 Apr 16;2(2):303-36
pubmed: 24957513
Medicines (Basel). 2020 May 09;7(5):
pubmed: 32397520
Clin Exp Immunol. 2008 Sep;153 Suppl 1:27-9
pubmed: 18721326
Contact Dermatitis. 2003 Mar;48(3):176-7
pubmed: 12755747
Molecules. 2021 Nov 26;26(23):
pubmed: 34885754
Biochem J. 2003 Aug 15;374(Pt 1):157-63
pubmed: 12697026
Curr Med Chem. 2012;19(11):1663-81
pubmed: 22257059
Pharmaceutics. 2022 Mar 03;14(3):
pubmed: 35335937