Age of onset of cerebral venous thrombosis: the BEAST study.

Male Pregnancy Young Adult Humans Female Aged Middle Aged Venous Thrombosis / epidemiology Age of Onset Intracranial Thrombosis / epidemiology Risk Factors
Cerebral venous thrombosis age of onset cerebral venous sinus thrombosis women

Journal

European stroke journal
ISSN: 2396-9881
Titre abrégé: Eur Stroke J
Pays: England
ID NLM: 101688446

Informations de publication

Date de publication:
03 2023
Historique:
received: 26 10 2022
accepted: 12 12 2022
medline: 7 4 2023
entrez: 6 4 2023
pubmed: 7 4 2023
Statut: ppublish

Résumé

Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset. We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females. A total of 1309 CVT patients (75.3% females) aged ⩾18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35-58) years and 37 (28-47) years ( Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (⩾1) risk factors suffer CVT ~12 years earlier compared to those with no identifiable risk factors.

Sections du résumé

Background
Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset.
Methods
We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females.
Results
A total of 1309 CVT patients (75.3% females) aged ⩾18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35-58) years and 37 (28-47) years (
Conclusions
Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (⩾1) risk factors suffer CVT ~12 years earlier compared to those with no identifiable risk factors.

Identifiants

DOI: 10.1177/23969873221148267 PMID: 37021156 PMC: PMC10069208
pubmed: 37021156
doi: 10.1177/23969873221148267
pii: 10.1177_23969873221148267
pmc: PMC10069208
doi:

Types de publication

Observational Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Pagination

344-350

Subventions

Organisme : NINDS NIH HHS
ID : U01 NS069208
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105150
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS100178
Pays : United States

Informations de copyright

© European Stroke Organisation 2023.

Déclaration de conflit d'intérêts

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Auteurs

Redoy Ranjan (R)

Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
ORCID: 0000-0003-1927-5023

Gie Ken-Dror (G)

Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.

Ida Martinelli (I)

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.

Elvira Grandone (E)

Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy.
Medical and Surgical Department, University of Foggia, Foggia, Italy.

Sini Hiltunen (S)

Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Erik Lindgren (E)

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Maurizio Margaglione (M)

Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Veronique Le Cam Duchez (V)

Normandy University, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit and INSERM CIC-CRB 1404, Rouen, France.

Aude Bagan Triquenot (A)

Department of Neurology, Rouen University Hospital, Rouen, France.

Marialuisa Zedde (M)

Neurology Unit, Stroke Unit, Local Health Unit - Authority IRCCS of Reggio Emilia, Reggio Emilia, Italy.

Michelangelo Mancuso (M)

Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.

Ynte M Ruigrok (YM)

UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.
ORCID: 0000-0002-5396-2989

Brad Worrall (B)

Department of Neurology, University of Virginia, Charlottesville, VA, USA.

Jennifer J Majersik (JJ)

Department of Neurology, University of Utah, Salt Lake City, UT, USA.

Jukka Putaala (J)

Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Elena Haapaniemi (E)

Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Susanna M Zuurbier (SM)

Department of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.

Matthijs C Brouwer (MC)

Department of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.

Serena M Passamonti (SM)

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.

Maria Abbattista (M)

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.

Paolo Bucciarelli (P)

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
ORCID: 0000-0003-0877-365X

Robin Lemmens (R)

Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium.
VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

Emanuela Pappalardo (E)

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Paolo Costa (P)

Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.

Marina Colombi (M)

Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy.

Diana Aguiar de Sousa (D)

Stroke Center, Lisbon Central University Hospital, Lisbon, Portugal.
CEEM and Institute of Anatomy, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
ORCID: 0000-0002-6702-7924

Sofia Rodrigues (S)

Department of Neurosciences, Hospital of Santa Maria, University of Lisbon, Lisbon, Portugal.

Patrícia Canhao (P)

Department of Neurosciences, Hospital of Santa Maria, University of Lisbon, Lisbon, Portugal.

Aleksander Tkach (A)

Department of Neurology, University of Utah, Salt Lake City, UT, USA.

Rosa Santacroce (R)

Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Giovanni Favuzzi (G)

Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy.

Antonio Arauz (A)

Stroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.

Donatella Colaizzo (D)

Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy.

Kostas Spengos (K)

Department of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.

Amanda Hodge (A)

McMaster University, Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada.

Reina Ditta (R)

McMaster University, Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada.

Thang S Han (TS)

Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Department of Diabetes and Endocrinology, Ashford and St Peter's NHS Foundation Trust, Chertsey, UK.

Alessandro Pezzini (A)

Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.

Jonathan M Coutinho (JM)

Department of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.

Vincent Thijs (V)

Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia.
ORCID: 0000-0002-6614-8417

Katarina Jood (K)

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Turgut Tatlisumak (T)

Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

José M Ferro (JM)

Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal.

Pankaj Sharma (P)

Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK.

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Classifications MeSH

Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Jeune adulte › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Sujet âgé › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Thrombose veineuse › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Âge de début › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thromboembolie › Embolie et thrombose intracrâniennes › Thrombose intracrânienne › Age of onset of cerebral venous thrombosis:...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Age of onset of cerebral venous thrombosis:...