An oseltamivir-resistant avian H1N1 influenza A virus can transmit from mallards to chickens similarly to a wild-type strain: implications for the risk of resistance transmission to humans.

Humans Animals Oseltamivir / pharmacology Chickens Influenza A Virus, H1N1 Subtype / genetics Influenza in Birds Antiviral Agents / pharmacology Influenza A virus / genetics Ducks Neuraminidase / genetics Drug Resistance, Viral Influenza, Human / drug therapy
antiviral resistance avian influenza chicken neuraminidase inhibitor oseltamivir pandemic preparedness

Journal

The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340

Informations de publication

Date de publication:
04 2023
Historique:
medline: 7 4 2023
entrez: 5 4 2023
pubmed: 6 4 2023
Statut: ppublish

Résumé

The neuraminidase inhibitor (NAI) oseltamivir is stockpiled globally as part of influenza pandemic preparedness. However, oseltamivir carboxylate (OC) resistance develops in avian influenza virus (AIV) infecting mallards exposed to environmental-like OC concentrations, suggesting that environmental resistance is a real concern. Herein we used an

Identifiants

DOI: 10.1099/jgv.0.001835 PMID: 37018118
pubmed: 37018118
doi: 10.1099/jgv.0.001835
doi:

Substances chimiques

oseltamivir carboxylate K6106LV5Q8
Oseltamivir 20O93L6F9H
Antiviral Agents 0
Neuraminidase EC 3.2.1.18

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Erik Skog (E)

Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Marie Nykvist (M)

Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Mahmoud M Naguib (MM)

Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Michelle Wille (M)

Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Present address: Sydney Institute for Infectious Diseases, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, New South Wales, Sydney, Australia.

Caroline Bröjer (C)

Department of Pathology and Wildlife Disease, Swedish Veterinary Institute, Uppsala, Sweden.

Viktoria Agarwal (V)

Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Present address: Institute of Environmental Engineering, ETH, Zürich, Switzerland.

Patrik Ellström (P)

Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Gabriel Westman (G)

Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.

Åke Lundkvist (Å)

Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Josef D Järhult (JD)

Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Eucaryotes › Animaux › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclohexanes › Cyclohexènes › Oséltamivir › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Poulets › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H1N1 du virus de la grippe A › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Maladies de l'animal › Maladies des oiseaux › Grippe chez les oiseaux › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Canards › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Sialidase › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance virale aux médicaments › An oseltamivir-resistant avian H1N1 influenza...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › An oseltamivir-resistant avian H1N1 influenza...