A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac.
desmoid-type fibromatosis
sulindac
surgery
tamoxifen therapy
wnt
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
accepted:
03
03
2023
medline:
6
4
2023
entrez:
5
4
2023
pubmed:
6
4
2023
Statut:
epublish
Résumé
Desmoid tumors are locally aggressive benign tumors arising from connective tissue and are classified as soft tissue sarcomas that do not metastasize. The name is derived from the Greek word desmos that means tendon-like. These tumors are also known as aggressive fibromatosis and have an unpredictable natural history that varies depending on risk factors. They are treated as sarcomas because of their locally aggressive nature and a high local recurrence rate. The causes behind desmoid tumor development are enigmatic and their clinical course is unpredictable. Disease progression also varies widely depending on multiple syndromic risk factors. At this time, there is no scientific consensus over best treatment practices for this tumor type. Treatment can potentially be a combination of observation, systemic therapy, surgery or radiation therapy. Here, we have described a case of a female patient with a sporadic desmoid tumor that successfully responded to tamoxifen and sulindac.
Identifiants
pubmed: 37016646
doi: 10.7759/cureus.35723
pmc: PMC10066902
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e35723Informations de copyright
Copyright © 2023, Choudhury et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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